2024 한국생물공학회 춘계학술발표대회 및 국제심포지엄

3-Minute Speech & Poster Presentation

Program

3-Minute Speech & Poster Presentation
•나노바이오공학 / Nano-Bioengineering
•단백질/효소공학 / Protein and Enzyme Engineering
•미생물공학 및 생물공정공학 / Microbial and Bioprocess Engineering
•바이오화학 및 화장품 생물공학 / Bio-based Chemicals and Cosmetic Bioengineering
•식품생물공학 / Food Biotechnology
•에너지 및 환경생물공학 / Energy and Environmental Biotechnology
•의공학 및 바이오제약공학 / Biomedical and Biopharmaceutical Engineering
•조직공학 및 생체재료공학 / Tissue Engineering and Biomaterial Engineering
•합성생물공학 및 대사공학 / Synthetic Biology and Metabolic Engineering
•항체공학 및 세포배양공학 / Antibody Engineering and Cell Culture Engineering

Plenary Lecture Ⅰ
Prof. Shuichi Takayama Georgia Institute of Technology USA H-index=81 Organoid, Cellchip, Organic chemistry Professor, GRA Eminent Scholar Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine	Background Dr. Shu Takayama earned his BS and MS in Agricultural Chemistry at the University of Tokyo. He earned a PhD in Chemistry at The Scripps Research Institute in La Jolla, California studying bio-organic synthesis with Dr. Chi‐Huey Wong. He then worked as a postdoc with Dr. George Whitesides at Harvard University where he focused on applying microfluidics to studying cell and molecular biology. Dr. Takayama began his career at the University of Michigan, where led his lab in the Department of Biomedical Engineering and Macromolecular Science & Engineering for over 17 years. In 2017, the lab moved to Georgia Tech where Shu became the Georgia Research Alliance Price Gilbert Chair Professor of Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering. Dr. Takayama’s research interests are diverse and motivated by clinical and biotechnology needs. He is always interested in hearing from stakeholders in these areas who are seeking engineering collaboration.

Plenary Lecture Ⅰ

Prof. Shuichi Takayama
Georgia Institute of Technology USA
H-index=81 Organoid, Cellchip, Organic chemistry
Professor, GRA Eminent Scholar
Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine

Background

Dr. Shu Takayama earned his BS and MS in Agricultural Chemistry at the University of Tokyo. He earned a PhD in Chemistry at The Scripps Research Institute in La Jolla, California studying bio-organic synthesis with Dr. Chi‐Huey Wong. He then worked as a postdoc with Dr. George Whitesides at Harvard University where he focused on applying microfluidics to studying cell and molecular biology.
Dr. Takayama began his career at the University of Michigan, where led his lab in the Department of Biomedical Engineering and Macromolecular Science & Engineering for over 17 years. In 2017, the lab moved to Georgia Tech where Shu became the Georgia Research Alliance Price Gilbert Chair Professor of Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering.
Dr. Takayama’s research interests are diverse and motivated by clinical and biotechnology needs. He is always interested in hearing from stakeholders in these areas who are seeking engineering collaboration.

Plenary Lecture Ⅱ
Prof. Ashutosh Chilkoti Duke University USA H-index=103 Colorimetric biosensor, Drug Delivery	Background Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University. My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery. Appointments and Affiliations Alan L. Kaganov Distinguished Professor of Biomedical Engineering Professor of Biomedical Engineering Research Professor of Global Health Professor in the Department of Chemistry Core Faculty in Innovation & Entrepreneurship Member of the Duke Cancer Institute Research Interests Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery. Awards, Honors, and Distinctions Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015 Fellow. National Academy of Inventors. 2014 Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013 Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011 Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011 Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010 Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008 Fellow. American Institute for Medical and Biological Engineering. 1996

Plenary Lecture Ⅱ

Prof. Ashutosh Chilkoti
Duke University USA
H-index=103 Colorimetric biosensor, Drug Delivery

Background

Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University.
My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.

Appointments and Affiliations

Alan L. Kaganov Distinguished Professor of Biomedical Engineering
Professor of Biomedical Engineering
Research Professor of Global Health
Professor in the Department of Chemistry
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Cancer Institute

Research Interests

Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery.

Awards, Honors, and Distinctions

Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015
Fellow. National Academy of Inventors. 2014
Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013
Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010
Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008
Fellow. American Institute for Medical and Biological Engineering. 1996

Plenary Lecture Ⅲ
Prof. Jens Nielsen Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden	Background Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering. Presentation Systems Biology of Yeast Metabolism Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅲ

Prof. Jens Nielsen
Department of Biology and Biological Engineering, Chalmers University of Technology,
Gothenburg, Sweden

Background

Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering.

Presentation

Systems Biology of Yeast Metabolism

Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅳ
Prof. Ron Milo Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel	Background Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics: Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals. Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity. Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food. Cell biology & Sustainability by numbers. http://book.bionumbers.org/ Presentation Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂ The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅳ

Prof. Ron Milo
Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel

Background

Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics:
Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals.
Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity.
Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food.
Cell biology & Sustainability by numbers. http://book.bionumbers.org/

Presentation

Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂

The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅴ
Prof. Jay D. KEASLING Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA	Background Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors Presentation Engineered Polyketide Synthases as Platform for Synthetic Chemistry Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅴ

Prof. Jay D. KEASLING
Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA
Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA

Background

Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors

Presentation

Engineered Polyketide Synthases as Platform for Synthetic Chemistry

Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅵ
Prof. Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea	Background Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology. Presentation Bioelectronic Nose for Odor Standardization Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

Plenary Lecture Ⅵ

Prof. Tai Hyun PARK
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea

Background

Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology.

Presentation

Bioelectronic Nose for Odor Standardization

Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

[S2-1] Honorary Lecture by Biotech CEO
Vice President Hyungduk Yoo LOTTE BIOLOGICS Co., Ltd., Korea	Business Outlook of LOTTE Biologics Abstract Established in June 2022, LOTTE BIOLOGICS is rapidly expanding its business with the goal of becoming a global Top 10 CDMO (Contract Development and Manufacturing Organization). Through the successful acquisition of the Syracuse biopharmaceutical manufacturing facility of the globally renowned Bristol Myers Squibb (BMS), located in New York, LOTTE BIOLOGICS was able to enter the CDMO market within just 8 months. With the vision of “Delivering Therapies that Enable a Healthier World,” LOTTE BIOLOGICS aims to provide ‘end-to-end’ CDMO services to clients, from the early stages of development to clinical and commercial production.

[S2-1] Honorary Lecture by Biotech CEO

Vice President Hyungduk Yoo
LOTTE BIOLOGICS Co., Ltd., Korea

Business Outlook of LOTTE Biologics

Abstract
Established in June 2022, LOTTE BIOLOGICS is rapidly expanding its business with the goal of becoming a global Top 10 CDMO (Contract Development and Manufacturing Organization). Through the successful acquisition of the Syracuse biopharmaceutical manufacturing facility of the globally renowned Bristol Myers Squibb (BMS), located in New York, LOTTE BIOLOGICS was able to enter the CDMO market within just 8 months. With the vision of “Delivering Therapies that Enable a Healthier World,” LOTTE BIOLOGICS aims to provide ‘end-to-end’ CDMO services to clients, from the early stages of development to clinical and commercial production.

[S2-2] Special Lecture Commemorating the Academic Award
Prof. Duk Jae Oh Sejong University, Korea	Enhanced Productivities in Animal Cell Technology : My Experiences Abstract Animal cell technology has been a key platform technology particularly in production of biopharmaceuticals such as therapeutic antibodies, highly glycosylated therapeutic proteins, vaccines and cell/gene therapy products. However, since its industrial applications in early 1980s, the enhancement of the productivity from animal cells has been a strong challenge in animal cell technology due to its lower productivity compared to well-established microbial production system, even though the current productivity of antibodies from recombinant CHO cells reaches higher than 10g/L. Application and progress in the new areas such as ‘cultured meat’ and ‘stem cell technology’ also accelerate the needs for productivity enhancement. In this presentation, the efforts for enhanced productivity from animal cells will be discussed particularly with bioreactor development, cell culture process such as fed-batch and perfusion cultures, cell culture medium development, and cell engineering to establish more productive cell lines. The productivity still matters in animal cell technologies even in the twenty-first century. Keywords productivity, animal cell technology, bioreactor, cell culture process, cell culture medium

[S2-2] Special Lecture Commemorating the Academic Award

Prof. Duk Jae Oh
Sejong University, Korea

Enhanced Productivities in Animal Cell Technology : My Experiences

Abstract
Animal cell technology has been a key platform technology particularly in production of biopharmaceuticals such as therapeutic antibodies, highly glycosylated therapeutic proteins, vaccines and cell/gene therapy products. However, since its industrial applications in early 1980s, the enhancement of the productivity from animal cells has been a strong challenge in animal cell technology due to its lower productivity compared to well-established microbial production system, even though the current productivity of antibodies from recombinant CHO cells reaches higher than 10g/L. Application and progress in the new areas such as ‘cultured meat’ and ‘stem cell technology’ also accelerate the needs for productivity enhancement.
In this presentation, the efforts for enhanced productivity from animal cells will be discussed particularly with bioreactor development, cell culture process such as fed-batch and perfusion cultures, cell culture medium development, and cell engineering to establish more productive cell lines. The productivity still matters in animal cell technologies even in the twenty-first century.

Keywords
productivity, animal cell technology, bioreactor, cell culture process, cell culture medium

기관정보

기관명	한글	싸이티바 코리아	설립일	2019년 7월 1일
기관명	영문	Cytiva Korea	업종	도매 서비스 / 무역, 과학기자재, 진단시약 및 기자재, 오퍼
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		대표전화	02-6201-3800
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		홈페이지	www.cytivalifesciences.co.kr

주요 공적사항

Cytiva는 글로벌 공급자로서, 치료제의 개발 및 제조를 촉진하고 가속화하는 기술과 서비스를 제공하고 있습니다. 과거 GE Healthcare Life Sciences였던 Cytiva는 수십년을 거슬러 올라가는 풍부한 유산을 갖고 2020년부터 Cytiva 로 새롭게 시작했습니다. 우리의 고객은 기초 생물학적 연구에서부터 혁신적인 백신, 항체 및 재조합단백질의 바이오 의약품 및 새로운 세포 및 유전자 치료법 개발에 이르기까지 생명을 구하는 활동을 수행합니다. 우리의 임무는 그들이 더 나은 환경에서 더 빠르고 안전하게 일하는 데 필요한 도구와 서비스를 제공하여 더 나은 환자의 치료 결과를 이끄는 것입니다.
Cytiva는 글로벌 생명과학 리더로서, 삶을 변화시키는 치료법에 접근하여 인류의 건강을 증진시키고자 하는 비전에 전념하고 있습니다. Cytiva는 다양한 규모와 범위의 고객에게 신뢰할 수 있는 파트너로서, 연구 및 제조 워크플로우에 효율성을 제공하여 혁신적인 의약품의 개발과 제조, 그리고 환자에게 이를 전달하는 것을 보장합니다.

Cytiva Korea는 국내 바이오 기업들의 전문 기술력 육성에 대한 고민을 해결하는 데 도움을 주기 위해 <대한민국 바이오의약품 대상> 공모전을 후원하고 있습니다. 바이오의약품 개발 인프라 부족으로 어려움을 겪는 국내기업들을 대상으로 Cytiva의 제품과 패스트트랙센터 (Fast Trak Center)의 기술력을 함께 지원합니다. 배양/정제 공정 스크리닝, 공정 최적화, 공정 스케일업, 비임상시료 생산 등 제품 생산 전반에 걸쳐 제조공정 연구 및 양산에 도움을 드리려고 합니다.

대표기술

기술명	세포 배양 및 단백질 분리 정제를 위한 크로마토그래피 (chromatography) 기술

기술 개요

Cytiva만의 축적된 노하우를 바탕으로 바이오 의약품의 세포 배양/정제 공정 개발 및 스케일업, 분석법 개발, 기술이전, 미국 본사 cGMP 시설과 연계한 임상 시료 및 상업 생산을 지원합니다.
Cytiva의 목표는 특히 FAST TRAK center를 이용하여 고객이 직면한 공정상의 문제들을 해결하도록 도와주고 지원하는 것입니다.

기술 세부 내용

세포 배양의 기술은 싱글유즈 (Single-use) 장비를 이용한 바이오리액터 활용 및 업스트림 공정 개발 전략을 다룹니다. 공정 최적화 및 스케일-업을 위한 중요 변수 전반에 대한 것입니다. ReadyToProcess WAVE는 single-use bag 내부의 용액 움직임에 의한 믹싱 및 기체 전달 기능을 극대화한 single-use rocking bioreactor입니다. 세포 건강에 악영향을 주는 shear stress가 적고 single-use bag 사용으로 교차 오염 위험이 없어 연구 단계나 GMP 초기 종배양에 적합한 기술입니다.
Xcellerex bioreactor는 single-use 전문 브랜드로 바이오 의약품 개발, 생산 및 상용화 방식을 혁신하고 있습니다. 독창적인 바이오의약품 생산 플랫폼을 기반으로 구축된 혁신적인 single-use 어플리케이션 기술을 적용합니다.
단백질 분리 정제 (Protein purification)를 위한 기술과 방법의 개발은 생물공학분야에서 많은 발전을 위한 필수적인 전제조건이 되어져 왔다. 단백질 분리 정제는 간단한 one-step purification 과정에서부터 증명된 대량 정제의 생산 과정에까지 다양하다. 원하는 purity를 얻기 위해서는 종종 한번의 정제 과정 이상이 필요로 되어진다. 성공적인 단백질 정제는 적절한 technique을 선택하고, 그 방법으로 최상의 결과가 나오도록 optimization 하고, 수율 (yield)은 최대로 얻고 요구되는 정제 단계를 최소로 하는 것이다. 대부분의 단백질 정제는 크로마토그래피 (chromatography) 방법을 포함한다. 그 결과로 크로마토그래피는 단백질 정제를 위한 가장 필수적인 기술이다.

기술활용 범위

바이오 공정의 재조합 단백질, 항체, 백신 개발 및 생산을 위한 세포 배양 및 단백질 정제를 위한 분야에 폭넓게 사용되고 있으며, 또한 유전자 및 세로치료제 분야에 있어서도 배양 및 정제 기술을 활용하는 연구 및 생산에 적용되고 있습니다.

[S2-3] 학술대상 수상기념특강
Jeewon LEE Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV	Optimally Fabricated Platforms for Enhanced Cancer Therapy Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

[S2-3] 학술대상 수상기념특강

Jeewon LEE
Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV

Optimally Fabricated Platforms for Enhanced Cancer Therapy

Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

Special Session for Biotech Companies Ⅰ

Instruction

The technological advancement in biotechnology is a crucial factor that spans from fundamental research to industrial scale-up research. The Korean Society for Biotechnology and Bioengineering aims to share excellent research conducted by companies, from basic research to industrial intermediary research. In this session, we aim to invite researchers from leading companies such as Amorepacific, which is pioneering global cosmetics research, Eubiologics focusing on vaccine research, and CJ Cheiljedang and GC BioPharma Corporation, to explore the latest industrial trends. Your interest would be greatly appreciated.

	Biotechnology in the cosmetic industry VP Aiden ParkAMOREPACIFIC, Korea
	Introducing Eubiologics’ vaccine platform VP KyeongHo MinEubiologics Co., Ltd., Korea
	Synthetic Biology & Biofoundry for Sustainable future Team Leader Eun Ji KimCJ CheilJedang, Korea
	mRNA Platform Technology and Applications Team Leader Jaesung JungGC BioPharma, Korea

Special Session for Biotech Companies Ⅱ

Instruction

The technological advancement in biotechnology is a crucial factor that spans from fundamental research to industrial scale-up research. The Korean Society for Biotechnology and Bioengineering aims to share excellent research conducted by companies, from basic research to industrial intermediary research. In this session, we aim to invite researchers from technology-driving companies such as Daesang, Samyang, Cytiva, and Sartorious Korea Biotech, to explore the latest industrial trends. Your interest would be greatly appreciated.

Chair

Professor Sung-ok HanKorea University, Korea

	Introduction of R&D Center in Daesang Corp. Team Lead Jung-Hoon KimDaesang, Korea
	Enzyme engineering, empowered by AI/ML: A new frontier in enzyme optimization Team Manager Tae Yong KimSamyang Corp, Korea
	Bispecific antibody / recombinant protein Resin BP Resin Sales Specialist Jeongbae ParkCytiva, Korea
	Sartorius Octet®: Paving the Way for Safer Biologic Therapies Field Application Specialist JiEun-HwangSartorius Korea Biotech, Korea

Recent Trends in the Development of Therapeutic Biologics

Instruction

Designing and engineering new biologics has played essential roles in developing novel therapeutics and expanding the scope of medicine. This session covers representative works of developing next-generation therapeutic biologics against various diseases. The first speaker (Prof. Kim) presents an innovative approach to using endogenous virus-specific CD8+ T cells for cancers based on tumor-specific cytosol-penetrating antibodies. Prof. Jung describes various antibody Fc variants his group has developed so far, which can endow superior functions to antibody therapeutics. Then, Prof. Van Deventer presents a new platform technology to discover crosslinkable antibodies and its application in developing inhibitors against a Botulinum Neurotoxin target. The last speaker (Prof. Lee) presents the analysis results of antibody repertoires to influenza and SARS-CoV-2 and shows how they can be used in engineering antibodies and vaccines.

Professor Tae Hyeon Yoo

Ajou University, Korea

	Keynote Speaker Immunocytokines as Emerging Therapeutics for Cancer Immunotherapy: Focusing on IL-12 Immunocytokine Professor Yong-Sung KimAjou University, Korea
	Invited Speaker Palette of Antibody Fc Variants That Enable Therapeutic Potency Boosting, Effector Function Silencing, or Circulating Half-Life Extension Professor Sang Taek JungKorea University, Korea
	Invited Speaker Covalent Antibody Discovery on the Yeast Surface Against a Botulinum Neurotoxin Target Professor James A. Van DeventerTufts University, USA
	Invited Speaker An Immunoproteomic Survey of the Antibody Landscape: Insights and Opportunities Revealed by Immune Repertoire Profiling Professor Jiwon Lee Dartmouth College,USA

Co-organized by

Synthetic Biology of Secondary Metabolite Producers for Drug Discovery and Development

Instruction

Synthetic biology and metabolic engineering together with related principles and technologies endeavor to redesign and optimize the genetic and regulatory processes of various organisms for our society's sake. In this session, we will discuss recent advances in synthetic biology of secondary metabolite producers with an emphasis on small molecules with human benefits.

Professor Dokyun Na

Chung-Ang University, Korea

	Keynote Speaker Leveraging a Large Actinobacterial Strain Collection for Natural Product Biosynthesis, Engineering, and Drug Discovery Professor Ben ShenUF Scripps Biomedical Research, USA
	Invited Speaker Multi-engineering of microbial cytochrome P450 enzymes Professor Shengying LiShandong University, China
	Invited Speaker Characterization and Engineering of Microbial Small Molecule Biosynthesis for Drug Discovery Professor Yeo Joon YoonSeoul National University, Korea
	Invited Speaker Production of natural sunscreen materials in yeasts Professor Ji-Sook Hahn Seoul National University, Korea
	Invited Speaker Systems Metabolic Engineering for the Enhanced Production of Secondary Metabolites Professor Hyun Uk Kim KAIST, Korea

Antibody Engineering and Cell Culture Engineering

Instruction

The current status of antibody drug research and bioprocess development from top-tier scientists who are most active at the forefront of academia and industry in relation to antibody drug development will be presented. The main topics of discussion are antibody engineering, biologics development, cell culture engineering, and biomanufacturing including media development. It will be an influential forum for leaders and experts from academic and industrial backgrounds to convene and discuss antibody engineering, cell culture engineering, and the related advancements that impact a growing spectrum of modalities including recombinant biologics and downstream processing. Various discussions between academia and industry on related topics will be held.

Professor Soonjo Kwon

Inha University, Korea

Professor Jae Seong Lee

Ajou University, Korea

	Keynote Speaker Demands of secreted protein products - systems biology improve quality and titer of biologics Professor Johan RockbergKTH Royal Institute of Technology, Sweden
	Invited Speaker Real-time monitoring and multi-scale modeling for bioprocess Digital Twin systems toward biomanufacturing 4.0 Professor Dong-Yup LeeSungkyunkwan University, Korea
	Invited Speaker Maximizing performance of your biologics pipeline: Media and process optimization using cutting-edge tools Chief Scientist Yaron SilberbergAjinomoto Genexine, Co., LTD., Korea
	Invited Speaker Stereospecific interactions between histidine and monoclonal antibodies Professor Youngbin Baek Inha University, Korea

Co-organized by

Biosensing Technology & Cell Engineering I

Instruction

This section invites key researchers with expertise in the fields of Biosensing Technology & Cell Engineering. In this symposium, we will discuss Biosensing strategies for developing sensitive biosensors to detect diseases and cell engineering for therapeutics. Speakers present the leading-edge trends and technologies in these fields with a special focus on the applications and developments of biosensor, nanomedicine, stem cell engineering, and tissue engineering. (This symposium is supported by Institute of Integrated Biotechnology and the BK21 Four MCCBE Research Team in Sogang university)

Professor Jeong-Woo Choi

Sogang University, Korea

	Keynote Speaker Innovative Biosensing Technologies to Realize Continuous, Real-time, In Vivo Monitoring Systems Professor Koji SodeUniversity of North Carolina and North Carolina State University, USA
	Keynote Speaker Engineering organoids for regenerative medicine and drug discovery Professor Seungwoo ChoYonsei University, Korea
	Invited Speaker Label-free Detection of Transport Kinetics and Inhibitor Binding of Membrane Transport Proteins with a Two-mode Plasmonic Sensor Professor Ling ChaoNational Taiwan Univeristy, Taiwan
	Invited Speaker Ultrasound Detection of Microcalcification for Early Detection of Breast Cancers and Differential Diagnosis Professor Yangmo Yoo Sogang University, Korea

Biosensing Technology & Cell Engineering II

Professor Taewook Kang

Sogang University, Korea

	Keynote Speaker Biosensor Integrated Internet of Things for Infectious Disease Point of Care Testings Professor Chenzhong Li Tulane University School of Medicine, USA
	Keynote Speaker Cutting-edge technologies for isothermal molecular diagnostics of COVID-19 Professor Hyun Gyu ParkKAIST, Korea
	Invited Speaker Aptameric enzyme subunit for homogeneous detection enabling in situ detection Professor Kazunori IkebukuroTokyo University of Agriculture and Technology, Japan
	Invited Speaker Electrochemical Nanobiosensor for Detection of Viral RNA and Its Mutation Derivative Using Nanoporous Electrode Array (NPEA) Professor Jinho Yoon The Catholic University of Korea, Korea

Co-organized by

Circadian Rhythm and Human Health

Instruction

This special symposium introduces cutting-edge researches focused on the relationship between circadian rhythm and human health. The aim of the special session is to further enhance our understanding of the circadian rhythm topic by inviting 3 prominent speakers who are conducting the state-of-the-art researches on the subject in the United States, Japan, and Korea. Additionally, we will introduce/discuss the research direction of BCA2-RLRC (Biological Clock-based Anti-Aging Convergence Regional Leading Research Center), which was recently launched with the support of the National Research Foundation of Korea.

Professor Seung Pil Pack

Korea University, Korea

Professor Jin Hyub Lee

Korea University, Korea

	Invited Speaker Circadian Rhythm and Human Health: Researches of BCA2-RLRC Professor Seung Pil PackKorea University, Korea
	Keynote Speaker Emerging Links between Circadian Disruption and Cancer Risk Professor Katja A. LamiaScripps Research, USA
	Invited Speaker Towards Systems Biology of Human Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep Professor Hiroki R. UedaThe University of Tokyo, Japan
	Invited Speaker Suprachiasmatic VIP Neurons Control Circadian Priority of Social Instincts Professor Han Kyoung ChoiDGIST, Korea

Co-organized by

LNP/mRNA Therapeutics

Instruction

The session presents the current research trend on the development of lipid nanoparticle and mRNAs for therapeutic purposes. Professor M.J. Mitchell is an expert on developing novel lipid nanoparticles and applying immunoengineering for the delivery of mRNA therapy. In addition, Professor Hyun Jung Chung from KAIST is also an expert in designing lipid nanoparticles for gene delivery. The last two speakers of the session Professor Kyuri Lee and Professor Jinkuk Kim are experts in RNA therapeutics.

Professor Hyun Jin Kim

Inha University, Korea

Professor Yoosik Kim

KAIST, Korea

	Invited Speaker Lipid Nanoparticles for Overcoming Biological Barriers to Nucleic Acid Delivery Professor Michael J. MitchellUniversity of Pennsylvania, USA
	Invited Speaker Reinforcing Nanoformulations via Chemical Tailoring for in vivo Gene Editing and Delivery Professor Hyun Jung ChungKAIST, Korea
	Invited Speaker Development of RNA structures for cancer immunotherapy Professor Kyuri LeeGyeongsang National University, Korea
	Invited Speaker Antisense oligonucleotide (ASO) as an artificial non-coding RNA to treat diseases Professor Jinkuk KimKAIST, Korea

Co-organized by

BEST-SBJ-KSBB Joint Session I

Instruction

This session presents the joint symposium of Korea-Japan-Taiwan Biotechnology and Bioengineering Societies. A total of eight speakers representing each of the three participating countries will present recent research trends in the community. The presentation will cover a range of topics from traditional microbial engineering to biomedical engineering.

Professor Youngeun Kwon

Dongguk University, Korea

ProfessorYun Jung Heo

Kyung Hee University, Korea

	Invited Speaker Valorization of Spent Mushroom Substrate (SMS) for Circular Bioeconomy Professor Yoong Kit LeongTunghai University, Taiwan
	Invited Speaker Optogenetic approaches for efficient microbial bio-productions Professor Yoshihiro ToyaOsaka University, Japan
	Invited Speaker Development of Tumor Microenvironmental-response Nanoparticles for Effective Cancer Treatment Professor Yun Suk HuhInha University, Korea
	Invited Speaker A New Way of Using Spent Coffee Grounds: Photothermal materials Professor Hsiu-Wen ChienNational Kaohsiung University of Science and Technology, Taiwan

BEST-SBJ-KSBB Joint Session II

Professor Yoosik Kim

KAIST, Korea

ProfessorSeung Pil Pack

Korea University, Korea

	Invited Speaker Artificial lipidation for biomolecular engineering at biointerface Professor Noriho KamiyaKyushu University, Japan
	Invited Speaker Membrane dynamics and its application to biotechnology Professor Masahiro TakagiJapan Advanced Institute of Science and Technology, Japan
	Invited Speaker Cyclic Breathing Lung Inflammation Model for Pulmonary Drug Screening Professor Jen-Huang (Tony) HuangNational Tsing Hua University, Taiwan
	Invited Speaker RNA-based predictive marker for chemotherapy Professor Yoosik KimKorea Advanced Institute of Science and Technology, Korea

Co-organized by

Application of Mass Spectrometry in Biotechnology

Instruction

Mass spectrometry (MS) has emerged as a powerful analytical tool in the fields of biotechnology, providing high throughput data for identification and characterization of biomolecules with high sensitivity and accuracy. The ability of MS to produce detailed information about the sequence, structure, and dynamics of biological molecules has revolutionized various aspects of biotechnological research and development. This session will explore the diverse applications of MS in biotechnology, including protein sequencing, drug development and immune peptide identification. Our speakers will highlight recent advances, challenges, and future prospects of MS techniques in biotechnology, emphasizing their crucial role in advancing our understanding of complex biological systems and facilitating innovation in biopharmaceuticals, personalized medicine, and biotechnology.

Chair

Professor Daechan ParkAjou University, Korea

	Invited Speaker Robust and Scaleable Single-molecule Protein Sequencing with Fluorosequencing Chief Technology Officer Jagannath SwaminathanErisyon, USA
	Invited Speaker Chemical Proteomics Approach for Drug Interaction Study Professor Jun-Seok LeeKorea University College of Medicine, Korea
	Invited Speaker Identification of Immunopeptidome for HLA-A*33:03 with Mass Spectrometry Professor Byoung Joon KoSungshin Women's University, Korea
	Invited Speaker Quantitative Proteome Analysis based on Mass Spectrometry for Translational Research and Drug Development Professor Kyunggon KimUniversity of Ulsan College of Medicine, Korea

Co-organized by

Integrating Biotechnology and Food Science: A Multidisciplinary Approach

Instruction

This international academic session, themed "Integrating Biotechnology and Food Science: A Multidisciplinary Approach," aims to explore the latest research trends and the integration of innovative technologies in the fields of biotechnology and food science. The session will provide an in-depth analysis of how advances in biotechnology can be applied to food science, enhancing food safety, nutritional value, and sustainability. Furthermore, it will focus on exploring the future direction of food biotechnology and strategic approaches for the sustainable development of the global food industry. Emphasizing the importance of interdisciplinary research, this session will serve as a platform for experts in biotechnology, food science, chemistry, and related fields to share their research findings and seek collaborative opportunities. Through this, participants will have the opportunity to integrate knowledge from various disciplines to understand complex food systems and develop innovative solutions. This session promises to offer insights into the creation of new values and the potential for advancement in research fields through the fusion of biotechnology and food science.

Chair

Director Daehee Lee KRIBB, Korea

	Keynote Speaker Studies on Unidentified Oligosaccharides in Sake Professor Masafumi Tokuoka Tokyo University of Agriculture, Japan
	Keynote Speaker Machine Learning-based Solubility Prediction of Organic Solvent, Polymers and Proteins Professor Seonah Kim Colorado State University, USA
	Invited Speaker Non-transgenic Engineering of Saccharomyces boulardii as a Prebiotic Biomaterial Professor Suryang Kwak Kookmin University, Korea
	Invited Speaker Compositional and Temporal Division of Labor Modulates Mixed Sugar Fermentation by an Engineered Yeast Consortium Researcher Jonghyeok Shin KRIBB, Korea

Sponsored by

Updates on Recent Developments in Cell-Free Synthetic Biology

Instruction

Cell-free synthetic biology technology addresses the challenges associated with cell-based approaches and is rapidly expanding its application range by solving the problems that are difficult to achieve with living cells. Research based on bottom-up synthetic biology using cell-free systems is actively being conducted in various fields, including the synthesis of hard-to-express proteins, prototyping of metabolic pathways, biosensing, and the construction of artificial cells. In this session, we aim to share the latest research achievements and discuss future development directions of related technologies through lectures by prominent speakers who are actively conducting research on these major issues.

Chair

Professor Taek Jin Kang Dongguk University, Korea

	Keynote Speaker Artificial Cell Reactor Technology Professor Hiroyuki NojiThe University of Tokyo, Japan
	Invited Speaker Detection of Single-Stranded Nucleic Acids Based on Cell-Free Protein Synthesis and Retroreflection Signal Detection Professor Taehyeon YooAjou University, Korea
	Invited Speaker Cell-Free Metabolic Engineering for Terpenoid Biosynthesis Professor Hyungdon Yun Konkuk University, Korea
	Invited Speaker Design a Robust MicroRNA Biosensors Using the Cell-Free System Assistant Professor Yongchan Kwon Lousiana State University, USA

Co-organized by

Precision Fermentation for Sustainability and Human Well-being

Instruction

Precision fermentation stands as an emerging frontier in biotechnology, dedicated to the sustainable and cost-effective production of food ingredients and nutrients through microbial fermentation. Recent advances in metabolic engineering and synthetic biology have propelled precision fermentation beyond conventional microbial fermentation methods. This session will showcase keynote and invited presentations highlighting the utilization of "food-grade" microorganisms, precise genome editing, and metabolic engineering to craft scarce food ingredients, alternative proteins, and fermented foods, as well as product development.

Chair

Professor Yong-Cheol Park Kookmin University, Korea

	Keynote Speaker Synthesis of Prebiotic Exopolysaccharides via Precision Genome Engineering in Lactic Acid Bacteria Professor Nam Soo HanChungbuk National University, Korea
	Invited Speaker Enhancing Food Flavors and Nutrition Through Precision Fermentation Professor Yong-Su JinUniversity of Illinois at Urbana-Champaign, USA
	Invited Speaker Precision Fermentation to Enhance Fucosylated Human Oligosaccharides Production Professor Jae Won LeeSungshin Women’s University, Korea
	Invited Speaker Yeast Metabolic Engineering to Produce Key Ingredients for Alternative Protein Products Professor Sun-Ki Kim Chung-Ang University, Korea
	Invited Speaker How Can We Commercialize Precision Fermentation CTO Jung-Hoon Kim Intake Co., Ltd., Korea

Pioneering Health Solutions: Bridging Biomedical Imaging, Soft Robotics, and Smart Diagnostics

Instruction

The 'Frontiers in Medical Technology: From Precision Diagnostics to Targeted Therapies' session explores transformative advancements in medical diagnostics, treatment precision, and therapies. Highlights include the integration of artificial intelligence in health monitoring through devices like the 'Precision Health Toilet' for non-invasive health data analysis. It also covers the development of microscale soft robotics in medicine, promising significant advancements in minimally invasive procedures. Additionally, the session discusses high-resolution photoacoustic imaging for deep biological tissue analysis, combining optical and ultrasound principles for detailed functional insights. Lastly, it introduces organoid-based drug/radiation sensitivity testing for personalized medicine, using 3D cell cultures to predict therapy outcomes. This session showcases the intersection of technology and medicine, advancing towards personalized, efficient healthcare.

Chair

Professor Yun Suk Huh Inha University, Korea
Professor Seung-min Park Nanyang Technological University, Singapore

	Invited Speaker Smart Connected Health: Artificial Intelligence and Advanced Data Science Professor Seung-min ParkNanyang Technological University, Singapore
	Invited Speaker High-Resolution Photoacoustic Imaging Techniques for Functional Analysis of Biological Tissue Professor Jeesu Kim Pusan National University, Korea
	Invited Speaker Microscale Soft Robotics for Medical Application Professor Doyeon BangChonnam National University, Korea
	Invited Speaker Cancer Organoid-based Drug/Radiation Sensitivity Tests for Precision Medicine Professor Dong Woo Lee Gachon University, Korea

Co-organizer by

Advanced Microbial and Bioprocess Engineering: Future Technologies and Innovation

Instruction

Microbial and biochemical engineering are disciplines related to various process technologies essential for the production of high-value-added biological products or eco-friendly products with significant industrial value. They cover a wide range of technologies at various scales, from biological reaction modeling that predicts/analyzes cell behavior, research on biochemical engineering to optimize bioprocess conditions, studies on bioreactors to maximize microbial catalyst activity, research on bioseparation processes for efficient purification of biological products, to ultimately designing bioprocesses for industrialization. Accordingly, this committee aims to host an international session to review recent trends in microbial and biochemical engineering, satisfying the interests of both the academic and industrial sectors within the KSBB. At the same time, it aims to contribute to the activation of discussions on technology development that encompasses both originality and industrial value.

Chair

Professor Nam Kyu Kang Kyung Hee University, Korea

	Keynote Speaker A Novel Bacterionanofiber Adhesin and the Development of Innovative bioprocesses Professor Katsutoshi Hori Nagoya University, Japan
	Invited Speaker Integrated Downstream Processes for Photosynthetic Microalgae Biorefinery Professor You-Kwan OhPusan National University, Korea
	Invited Speaker Yeast Metabolic Engineering for CO2 Fixation Professor Soo Rin KimKyungpook National University, Korea
	Invited Speaker Identification and Functional Analysis of a Polyethylene-degrading Enzyme Senior Researcher Jung Ho AhnKorea Institute of Science and Technology, Korea

Sponsored by

Recent Advances in Nanobiogenic Material-Based Biosensor and Diagnosis

Instruction

This session is to share recent advances in biosensors and diagnostics using various nanobiogenic materials and to discuss future research directions through open discussions. It would be helpful to all attendees for better understadning both biosensor and diagnsotic area.

Chair

Professor Hyun Ho Lee Myongji University, Korea

	Keynote Speaker Plasmonic Fluorescent Nanoparticles for High-Sensitivity Immunosensors Professor Min Gon KimGIST, Korea
	Invited Speaker Real-Time Automated Training and Sensing for Gas Odor (RATSGO) System Principal Researcher Moonil KimKRIBB, Korea
	Invited Speaker Nanoengineering of Extracellular Vesicles for Cancer Immunotherapy Professor Jiyoon BuInha University, Korea
	Invited Speaker Stimuli-responsive Hydrogels and Eutectogels Harboring Artificial Opal Micropatterns Professor Hyunmin Yi Tufts University, USA

New Bio-medical and Bio-pharmaceutical Approaches in Smart-Aging Era

Instruction

In the age of smart aging, innovative biomedical and biopharmaceutical approaches are revolutionizing the way we understand and manage aging. This session will explore cutting-edge research and developments that promise to extend healthy lifespan, improve quality of life for the elderly, and potentially reverse aspects of the aging process. Experts in the field will present on topics ranging from advanced genomics and personalized medicine to novel drug therapies and bioengineering solutions to combat age-related diseases and disorders. Participants will gain insights into the latest strategies for smart aging, including how technology, biotechnology and pharmacology can be used to maintain physical and mental health into old age. The session aims to foster a multidisciplinary dialogue and encourage collaboration among researchers, clinicians, and policy makers to address the challenges and opportunities of aging in the 21st century.

Chair

Professor Chang Sup Kim Dongguk University, Korea
Professor Byeong Hee Hwang Incheon National University, Korea

	Invited Speaker A Comprehensive Understanding of Context-specific Cancer Fitness Landscape for the Better Treatment Junior Group Leader Solip ParkCNIO, Spain
	Invited Speaker Drug Discovery for Anti-aging Using Molecular Modeling Professor Art E. ChoKorea University, Korea
	Invited Speaker α-Conotoxin TxIB Improved Behavioral Abnormality and Changed Gene Expression in Zebrafish (Danio rerio) Induced by Alcohol Withdrawal Lecturer Kailin MaoHainan Medical University, China
	Invited Speaker Harnessing Molecular Insights from Biological Silicification for Innovative Biotechnological Strategies Lecturer Mohamed AbdelhamidMinia Univeristy, Egypt

Co-organized by

Biotechnology for Sustainable Environment

Instruction

This session will explore the expansive potential of biotechnology, focusing on its role in the design and alteration of cellular systems. We will discuss how these advances enable the production of valuable compounds and offer solutions to environmental challenges. Our intent is to inspire attendees with the promising roles of biotechnology and its applications in creating a more sustainable future.

Chair

Professor Jay Keasling UC-Berkeley, USA
Professor Sung Kuk Lee UNIST, Korea

	Keynote Speaker Enhanced Production of Docosahexaenoic Acid (DHA) and Squalene in Unicellular Marine Thraustochytrid Protists Professor Guangyi Wang Tianjin University, China
	Invited Speaker Sustainable Production of Non-natural Acetins from Microbial Fermentation Professor Seon Won KimGyeongsang National University, Korea
	Invited Speaker Applications of Synthetic Biology in Non-model Microorganisms Senior Engineer Howard ChouShenzhen Institute of Advanced Technology, CAS, China
	Invited Speaker Permeability Engineered Next Generation Droplet for High Throughput Single Cell Analysis Young Principal Investigator Jingwei ZhangFudan University, China
	Invited Speaker Cupriavidus cauae PHS1: A Promising Thermotolerant Microrganism for Biorefinery Professor Sung Kuk Lee UNIST, Korea

Co-organized by

Advanced Materials for Biomedical ad Environmental Applications

Instruction

The session explores cutting-edge nanotechnology research in biomedicine and robotics. It commences with biocompatible nanoconstructs employing CRISPR-Cas9 RNP for precise gene editing. Subsequently, it investigates a single-nanoparticle-based digital SERS sensing platform, recognized for its sensitivity in disease biomarker detection. The focus then shifts to bioinspired mechanomaterials tailored for soft robotics, highlighting their flexibility and adaptability. Lastly, the session underscores biomimetic inorganic nanomaterials for augmenting biomedical applications. Attendees will gain exclusive insights into how these pioneers navigate challenges and opportunities, shaping nanotechnology's interdisciplinary impact on healthcare and robotics advancement.

Chair

Professor Ji Won Ha Ulsan University, Korea

	Invited Speaker Biocompatible nanoconstuct with CRISPR-Cas9 RNP for in vivo gene editing Principal Research Scientist Hyojin LeeKorea Institute of Science and Technology, Korea
	Invited Speaker Single-Nanoparticle-Based Digital SERS Sensing Platform for Ultrasensitive, Accurate and Quantitative Detection of Various Disease Biomarkers Principal Research Scientist Eun-Ah YouKorea Research Institute of Standards and Science, Korea
	Invited Speaker Bioinspired Mechanomaterials for Soft Robotics Assistant Professor Won-Kyu LeeHong-ik University, Korea
	Invited Speaker Biomimetic Inorganic Nanomaterials for Biomedical Applications Professor Jung Heon LeeSungkyunkwan University, Korea

Biotech Pioneers: Crafting the Future of High-Value Biomaterials

Instruction

"Biotech Pioneers: Crafting the Future of High-Value Biomaterials" is a pivotal session at the 2024 KSBB Spring Symposium, spotlighting industry leaders at the forefront of biomaterials innovation. This gathering serves as a platform for sharing cutting-edge research, technological advancements, and sustainable methodologies that redefine the standards in biotechnology. Attendees will gain exclusive insights into how these pioneers are navigating the challenges and opportunities in developing biomaterials that promise to revolutionize the sector and contribute to a sustainable future.

Chair

Professor Seon-Won Kim Gyeongsang National University, Korea

	Invited Speaker GenoFocus: Platform Technology Company Developing Enzyme and Biochemical Solutions Head of R&D center Taekho YangGenoFocus, Inc., Korea
	Invited Speaker Leveraging Skin Commensal Bacteria for Atopic Dermatitis Improvement Senior Researcher Young Mok HeoCOSMAX BTI, Korea
	Invited Speaker AMICOGEN, A Company Specializing in High-Value Biomaterial Research Director Jin Seok KimAMICOGEN, Korea
	Invited Speaker Nulla Bio: Pioneering the Future of Crop Genome Editing and Plant Synthetic Biology CEO Jae-Yean KimNulla Bio Inc., Korea

Co-organized by

Sponsored by

나노기술기반 진단 및 치료 국내외 연구동향 및 산업현황 조사 사업 성과발표회

	나노기술기반 진단 마케팅 동향 및 연구논문 분석과 최신기술 소개 이현호 교수명지대학교
	나노기술 기반 치료 관련 연구논문 분석과 최신기술 소개 이승환 교수한양대학교
	나노기술 기반 진단 분야의 Biosensors and Bioelectronics 연구논문 분석과 최신기술 소개 박기수 교수건국대학교
	포스트 코로나 시대 글로벌 진단시장 동향 및 예측 부지윤 교수인하대학교

Co-organized by

Special session for 2023 National R&D Excellence Top 100

Instruction

The Ministry of Science and ICT announced the final selection of the "Top 100 Achievements in National Research and Development for 2023." The Top 100 Achievements program, now in its 18th year, aims to enhance public understanding and interest in the role of science and technology that has propelled the nation's development. It seeks to boost the pride of scientists and researchers by recognizing outstanding national research and development outcomes across various government departments. This year, five members from our KSBB have been selected, and four of them have been invited to present and share their research achievements in this session.

	Keynote Speaker Effective Tissue Regeneration Using Adhesive Protein Biomaterial Professor Hyung Joon ChaPOSTECH, Korea
	Invited Speaker Towards Creating Bespoke Yeast Cells for Programmable Control of Cellular Functions Professor Ju Young LeeKAIST, Korea
	Invited Speaker Macroalgae Biorefinery: New Opportunity of Bioeconomy Professor Gyoo Yeol Jung POSTECH, Korea
	Invited Speaker Commercialization of Decellularized Tissue Matrix for Organoid Culture Professor Seung-Woo ChoYonsei University, Korea

Recent Trends in Bio-based Chemicals and Cosmetic Biotechnology

Instruction

The bio-based chemical industry refers to an industry that uses biomass, a renewable biological resource derived from carbon dioxide, as a raw material, or employs microorganisms or enzymes to produce chemical products such as biofuels, bioplastic, and biomaterials. It refers to a chemical industry that can grow sustainably based on bio-systems and breaks away from the petroleum-dependent chemical industry. By utilizing biotechnology, bio-cosmetics refers to cosmetics that have increased functionality and safety, including natural substances or metabolites produced by living things. It is expected that the profitability of the fast-growing Korean cosmetics industry will be further strengthened. Therefore, this session will introduce recent research trends in the fields of bio-based chemicals and cosmetic biotechnology.

Chair

Professor Sang Hyun Lee Konkuk University, Korea

	Keynote Speaker Technology Development Strategy for Sustainable Growth of K-Beauty Head/Professor Jae Sung HwangNational Center for Cosmetic R&D/Kyung Hee University, Korea
	Invited Speaker Insights into C50 Carotenoid Bacterioruberin from Haloarchaea as Potential Cosmetic Ingredient Professor Myung-Ji Seo Incheon National University, Korea
	Keynote Speaker Center for Bio-based Chemistry: Key Research and Research Achievements Head/Principal Researcher Hyun Gil Cha Korea Research Institute of Chemical Technology, Korea
	Invited Speaker Production of Polyhydroxybutyrate (PHA)s with Different Properties by Engineered Cupriavidus necator H16 Professor Yung-Hun Yang Konkuk University, Korea

Young Scientist Forum I

Instruction

This Young Scientist Forum will cover the state-of-the-art technologies in (1) Computational design of de novo protein nanostructure, (2) Enzyme cascade network technology, (3) Unveiling the biosynthetic properties of enzymes, and (4) Enzymatic biotransformation of valuable cosmetic and food ingredients (5) Screening of bioplastic degrading microorganisms

Chair

Professor Yoo Seong Choi Chungnam National University, Korea

	인사말 박경문 회장한국생물공학회 (KSBB)
	Computational design of de novo protein nanostructures and experimental validations Professor Sangmin LEE Pohang University of Science and Technology (POSTECH), Korea
	Enzyme cascade networks in confinement Professor Seong-Min JOPusan National University, Korea
	Unveiling the biosynthetic properties of thiolases to expand their application Professor Hyeoncheol Francis SONChonnam National University, Korea
	Biotransformation of Saponins in Ginseng and Bellflower as Cosmetic and Food Ingredients Professor Kyung-Chul SHINHankuk University of Foreign Studies, Korea
	Screening of Bioplastic Degrading Microorganisms and Assessing Biodegradability Senior Researcher Giyoung SHINKorea Research Institute of Chemical Technology (KRICT), Korea

Young Scientist Forum II

Instruction

This Young Scientist Forum will cover the state-of-the-art technologies in (1) Leveraging chromatin accessibility data and sequence-based machine learning, (2) Surface Tailored Nanomedicine for Cytosolic Delivery and Therapy, (3) 3D Bioprinting Application.

Chair

Professor Jeong-Geol Na Sogang University, Korea

Leveraging chromatin accessibility data and sequence-based machine learning to predict high-quality and context-specific regulatory sequences

Professor Seong Kyu HANInha University, Korea

Surface Tailored Nanomedicine for Cytosolic Delivery and Therapy

Professor Joonhyuck PARK The Catholic University of Korea, Korea

Thiol-Norbornene Photoclick Chemistry for 3D Bioprinting Application

Professor Min Hee KIMKyungpook National University, Korea

Co-organized by

Special Session for Hybrid Biohydrogen Production and Process Applications

Instruction

Hydrogen is emerging as an important reducing agent in the supply of eco-friendly automotive fuel cells and the pharmaceutical and cosmetics industries, steel, and various industrial applications, thus due to its increase of demand, it is urgent to develop technologies accordingly. In this session, we will look at the recent development of technologies and practical applications with experts from academia and industry on the production of eco-friendly biohydrogen production.

Chair

Professor Jung Rae Kim Pusan National University, Korea

	Invited Speaker Development and Demonstration of High-efficiency Hybrid Hydrogen Production System Integrating Pre-fermentation and Microbial Electrolysis Senior Managing Director/CTO Dae-Yeol CheongBioX, Inc., Korea
	Invited Speaker Development of Demonstration Technology for Energy Conversion Using Waste Resources Managing Director Unsik Hyun Samchully Co., Ltd., Korea
	Invited Speaker Bioelectrochemistry for the Nexus of Energy and Environmental Application Principal Researcher Soo Youn LeeKorea Institute of Energy Research, Korea
	Invited Speaker Key Construction and Operational Factors Influencing Bioelectrochemical System Performance Professor Gahyun BaekSungkyunkwan University, Korea

Co-organized by

Sponsored by

Therapeutics for Obesity, Diabetes, and NASH

Instruction

Obesity, diabetes, and non-alcoholic steatohepatitis (NASH) represent a trio of interconnected metabolic disorders with profound impacts on global health. This session delves into the innovative realm of therapeutics aimed at addressing these multifaceted conditions. From cutting-edge research to therapeutic breakthroughs, our panel of experts will navigate the intricate landscape of biotechnology and bioengineering in combatting obesity, diabetes, and NASH. Together, let's explore how biotechnology and bioengineering can pave the way towards effective solutions for the global burden of metabolic diseases.

Chair

Professor Inchan Kwon GIST, Korea

	Keynote Speaker Current and Emerging Treatments for Obesity and Type 2 Diabetes Professor A Ram HongChonnam National University Medical School, Korea
	Invited Speaker LY6D is Crucial for Lipid Accumulation and Inflammation in Nonalcoholic Fatty Liver Disease Professor Chang-Myung OhGIST, Korea
	Invited Speaker Oligopeptoplex for Adipocyte-targeted Anti-obesity Gene Therapy Professor Yong-Hee KimHanyang University, Korea
	Invited Speaker Understanding the Cell-matrix Interfaces That Control Cell Fate and Metabolic Disease Progression Professor Yongsung HwangSoonchunhyang University, Korea

Sponsored by

Utilization of Biological Environmental Resources

Instruction

We aim to promote collaborative research opportunities and enhance networking among researchers by sharing the latest trends and research outcomes in the fields of environmental engineering, biotechnology, and bioenergy, with a focus on sustainability through the application of biotechnology in biological environmental engineering and bioenergy.

Chair

Professor Sangsik Kim Kyungpook National University, Korea

	Invited Speaker Enhancing Anaerobic Digestion of Organic Wastewater through Understanding Microbial Communities and Magnetite Supplementation Professor Joonyeob Lee Pukyong National University, Korea
	keynote Speaker Bioelectrochemcial and Metabolic Conversion of CO2 into Succinate and Polyhydroxybutyrate (PHB) Professor Jung Rae KimPusan National University, Korea
	Invited Speaker The Carbon Seqeustration in Freshwater Sedimentary Environments by Microalgae Senior Researcher Sang Deuk LeeNakdonggang National Institute of Biological Resources, Korea
	Invited Speaker Synthetic Biology and Systems Biology for Efficient Biorefineries Professor Hyun Gyu LimInha University, Korea

Advances in white biotechnology: Frontiers in BioDesign

Instruction

BioDesign has emerged as a pivotal theme in white biotechnology and various other biotechnological domains. The intelligent and meticulous design of genes, gene regulation systems, enzymes, and microorganisms constitutes the essence of synthetic biology, serving as a prerequisite for the success of bioproduction, regardless of the nature of the intended products. In this engaging session, we are honored to host four distinguished speakers who will delve into the latest breakthroughs in BioDesign. Each talk will explore a specific facet of this dynamic field, showcasing its vital role in shaping the future of biotechnological applications.

Chair

Professor Donghyuk Kim UNIST, Korea
Professor Hyungyu Lim Inha University, Korea

	Invited Speaker De novo Design of Protein Nanocages Professor Sangmin Lee POSTECH, Korea
	Invited Speaker Computational Synthetic Biology Platform for Gene Therapy and mRNA Vaccine Development Professor Dong-Yup LeeSungkyunkwan University, Korea
	Invited Speaker Enzyme Activity Design Using Sequence Coevolution Information Professor Sanguk KimPOSTECH, Korea
	Invited Speaker Synthetic Gene Expression Control Systems in Microorganisms Professor Sang Woo Seo Seoul National University, Korea

Co-organized by

Sponsored by

New Horizons of Synthetic Biology and Biofoundry

Instruction

Synthetic biology has allowed us to design and to optimize various organisms that are suitable for industrial application. Furthermore, biofoundry powered by synthetic biology enables screening and application of tailor-made synthetic organisms in industry. In this session, we will discuss synthetic biology and biofoundry strategies with five eminent speakers in the fields.

Chair

Professor Si Jae Park Ewha Womans Univ., Korea

	Keynote Speaker Metabolic Engineering of Clostridium sp. JS66 for The Production of Hexanoic Acid and Hexanol Principal Researcher Youngsoon Um KIST, Korea
	Invited Speaker Multiplex Transcriptional Characterizations Across Diverse Bacteria Using Cell-free Systems Professor Sung Sun Yim KAIST, Korea
	Invited Speaker Discovery and Engineering of New Biocatalyst Using Transcriptional Regulator-based Biosensor Professor Soo-Jin Yeom Chonnam National University, Korea
	Invited Speaker Engineering Bacterial Spores as Living Filters for Development of Biodegradable Polyurethane Senior Researcher Myung Hyun NohKRICT, Korea
	Invited Speaker Development of a Target Gene Repression Tool for Diverse Bacteria Professor Dongsoo Yang Korea University, Korea

Journey to Carbon Neutrality: Development of Biological C1 Conversion Technologies

Instruction

As the impacts of climate change become increasingly apparent, humanity faces new challenges. Among the various efforts to mitigate climate change, converting C1 gases such as methane and carbon monoxide to produce fuels and chemical products holds significance in addressing social issues through greenhouse gas mitigation and creating new industries using alternative feedstocks. Biological C1 conversion routes utilize the specificity and selectivity of biological catalysts under mild conditions, offering solutions to conventional thermochemical methods with capital- and energy-intensive natures. In this session, we will explore the development path of C1 conversion technologies using biological transformation, discussing how far we have come and where we need to go. Additionally, we aim to examine the new prospects achievable through biotechnology by examining recent cases of carbon reduction efforts by biocompanies.

Chair

Professor Jeong-Geol Na Sogang University, Korea

	Keynote Speaker Elucidation of Electron Transfer in C1 Gas Converting Enzyme (CO Dehydrogenase) Professor Yong Hwan KimUNIST, Korea
	Keynote Speaker Biological Conversion of Methane Gas into Value-added Products Using Methanotrophs Professor Eun Yeol LeeKyung Hee University, Korea
	Invited Speaker Development of Biological C1 Conversion Process: How to Integrate Biocatalysts into Bioprocesses? Professor Jeong-Geol NaSogang University, Korea
	Invited Speaker Development of Sustainable Bio-based Industrial Process of L-Methionine Director Junwoo KimCJ Bio, Korea

Co-organized by

Special session for the 'Samsung Science & Technology' Program

Instruction

The 'Samsung Science & Technology' program consistently identifies cutting-edge researchers and projects poised to drive future advancements in science and technology. Through comprehensive support, this initiative propels our science and technology to greater heights, charting a course for a more promising future. The Program Director of 'Samsung Science & Technology' will commence the session with an informative talk, guiding KSBB members in understanding the program's objectives, purpose, and selection process. Following that, three principal investigators currently involved in individual projects will present and share not only outstanding research outcomes but also various experiences and anecdotes from the preparation and execution phases of their projects.

	Invited Speaker Samsung Research Funding & Incubation Center for Future Technology Program Director Sung-hong KwonSamsung Advanced Institute of Technology, Korea Program Director Whail ChoiSamsung Advanced Institute of Technology, Korea
	Invited Speaker Advancing Gene Therapy: The Promise of Directed Evolution in Developing Next-generation AAV Vectors Professor Jae-Hyung Jang Yonsei University, Korea
	Invited Speaker PLUG-IN CHEMISTRY: a highly efficient, site-specific bioconjugation technique based on molecular recognition Professor Seung Soo OhPOSTECH, Korea
	Invited Speaker Conversion of the Host Cell Receptor to Virus Destructor by Nanodisc Professor Dae-Hyuk KweonSungkyunkwan University, Korea

[S7-2] 국가연구안전관리본부 세미나

October 6, 2023, 11:50-13:00 (Room 101-102)

시험 ‧ 연구용 유전자변형생물체 안전관리 제도 및 규제동향
박수종 팀장
한국생명공학연구원 국가연구안전관리본부

Co-organized by

PSP01	PCR Chip-adopted Electrochemical Biosensor Module for Diagnosis of Infectious Diseases Won Jae KIM, Jun Yeong JANG, Min Kyung KIM, Jae Hee WON, Chae Min KIM, Minsub CHUNG Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP02	Activated Cell Proliferation by Reactive Oxygen Species Generated from Thimbleful Gold Nanorods Jae Wook LEE¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP03	Biotransformation of Phloretin Using Bacillus subtilis Spore Displayed Tyrosinase Yura JEONG^1,2, Chanjin PARK^1,2, Junehyung KIM^1,2 ¹Department of Chemical Engineering, College of Engineering, Dong-A University, Busan, Korea, ²Center for Sliver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan, Korea
PSP04	Comparison of the Efficiency of Heavy Metal Adsorption on the Cell Surfacedisplayed ECs Ho-Geun JEE, Haewon KIM, Seolhwa LEE, Jong-In WON Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP05	Application of the Porous Ootheca Recombinant Protein by Biomaterials Hye Jin HWANG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Yoo-Jin LEE⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon, Korea, ⁴Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP06	Characterization of Lactobacillus plantarum GNS300 for Various Commercial Applications Jae-Youn JUNG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Young-Keun SONG⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²2Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon,Korea, ⁴4Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP07	Construction of Bi-functional Enzyme of Formate Dehydrogenase and Glycerol Dehydrogenase by Peptide Linker in Methylorubrum extorquens AM1 Seo-young CHOI¹, Hyeonsoo KIM¹, Sukhyeong CHO², Jinwon LEE^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ² Gas Refinery R&D Center, Sogang University, Seoul, Korea
PSP08	Melanin Decolorizing Peroxidase Derived from Bjerkandera adusta Jina BAIK, Taek Jin KANG Department of Chemical Engineering, Dongguk University, Seoul, Korea
PSP09	Cosmetic Effects of Giant Mushroom, Pleurotus nebrodensis Hyo Jung JUNG, Seul Gi KWON, In Hae KIM, Jae hwa LEE Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University, Busan, Korea
PSP10	Metatranscriptome Analysis of Margalefidinium polykrikoides Harmful Algal Bloom Sang-Hyeok CHO^1,2, Yujin JEONG^1,2, Eunju LEE^1,2,Sangrak JIN^1,2, So-Ra KO³,Seung Ho BAEK⁴, Chi-Yong AHN³, Hee-Mock OH³, Byung-Kwan CHO^1,2, Suhyung CHO^1,2 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KI for BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, ⁴Risk Assessment Research Center, Korea Institute of Ocean Science and Technology, Geoje, Korea
PSP11	Assessment of Antibiofilm Potencies of Nervonic and Oleic Acid against Acinetobacter baumannii Using in vitro and Computational Approaches Sagar Kiran KHADKE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP12	Surface Modified PLGA Nanoparticles by Phospholipid for Enhanced Stability and Tissue Penetration Efficiency Doyeon KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, 2Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP13	Improved High-temperature Stability to Solve Cryogenic Transportation and Storage Problems of mRNA Vaccines Minjeong KIM, Taekyoung LEE, Hyunjin KIM, Heejae BANG, Minji KIM, Minsub CHUNG Chemical Engineering, Hongik University, Seoul, Korea
PSP14	Antibiofilm Activity of Saw Palmetto Oil, Lauric Acid, and Myristic Acid on Polymicrobial Biofilms Sang hun KIM, Sun young PARK, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP15	Inhibition of Biofilm Formation and Hyphal Growth of Candida albicans by Mediumchain Fatty Acids Ye Seul KIM, Afreen JAILANI, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP16	Self-assembled Nanocomplex-mediated siRNA Delivery Using Novel Fusion Peptide Yeong Chae RYU¹, Kyung Ah KIM¹, Byoung Choul KIM^1,2, Hui-Min David WANG³, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea, 3Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan
PSP17	Inhibition of Cutibacterium acnes Biofilm Formation by Fatty Acids Including Myristoleic Acid Sun young PARK, Sang hun KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea

PSP18	Diverse Roles of Microbial Indole Derivatives in Eukaryotic Systems Bharath Reddy BOYA, Prasun KUMAR, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP19	Review of pDNA Gene Delivery System Kyoungyeon OH¹, Eunbi LEE¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP20	Inhibition of Biofilm Formation and Virulence of Vibrio parahaemolyticus by Chloroindoles Olajide Sunday FALEYE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP21	shRNA-based Gene Therapy System Using Functional Peptides for the Treatment of Psoriasis Yoo Eun LEE¹, Yeong Chae RYU¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Devision of Bioengineering, Incheon National University, Incheon, Korea
PSP22	Non-invasive Cancer Diagnosis System Using C. elegans-on-a-chip and Odorant Markers Nari JANG¹, Arvie Camille V. DE GUZMAN², Shin sik CHOI^1,2 ¹Department of Food and Nutrition, Myongji University, Yongin, Korea, ²Department of Energy Science and Technology, Myongji University, Yongin, Korea
PSP23	Combination of Chemotherapy and Sonodynamic Therapy with Polylactide-poly (ethylene glycol) Polymersomes for Effective Cancer Treatments Youngheun CHO¹, Taeho KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP24	Antibiofilm and Antivirulence Activities of Fatty Acids Afreen JAILANI, Ye Seul KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP25	Development of Polymersomes Co-deliverying Dual-drug for Overcoming Multidrug Resistance EunKyung HAN¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP26	Designer Lipid Droplet Promotes Production of Value Added Biochemicals by Increasing the Storage Capacity So-Hee SON^1,2, Soo Young MOON³, Yeong-seon JANG¹, Seung Soo OH^2,3, Ju Young LEE¹ ¹Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan, Korea, ²School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, ³Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
PSP27	The Enhanced Production of Succinic Acid Using Engineered Type I Methanotroph Methylomonas sp. DH-1 Jeong-Ho PARK¹, Jae-Hwan JO¹, Min-sik KIM² ¹Gwangju Bio/Energy R&D center, Korea Institute of Energy Research, Gwangju, Korea, ²Energy Resources Upcycling Research Laboratory, Korea Institute of Energy Research, Daejeon, Korea
PSP28	Reconstruction of a Genome-scale Model of Eubacterium limosum Converting C1 Feedstocks to Multi-carbon Products Jiyun BAE, Yoseb SONG, Byung-Kwan CHO Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP29	Effect of Various Structured DNA on the Activity of Terminal Deoxynucleotidyl Transferase Myong Jin LEE, Eui Kyong JANG, Ki Sung PARK, Ki Ha MIN, Sung Ho KIM, Seung Pil PACK Department of Biotechnology and Bioinformatics, Korea University, Sejong, Korea
PSP30	Systematic Analysis on Transcription Unit Architecture of Streptomyces avermitilis Yongjae LEE¹, Namil LEE¹, Soonkyu HWANG¹, Woori KIM¹, Suhyung CHO¹, Bernhard O. PALSSON^2,3,4, Byung-Kwan CHO¹ ¹Department of Biological Sciences and KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ³Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁴Novo Nordisk Foundation Center for Biosustainability, Lyngby, Denmark
PSP31	Construction of the Knock-out Mutant Using a Purified Cas9 Protein in Chlamydomonas reinhardtii Junhwan JANG, Yoongil LEE, EonSeon JIN Department of Life Science, Hanyang University, Seoul, Korea
PSP32	Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome Soonkyu HWANG^1,2, Namil LEE^1,2, Donghui CHOE^1,2, Yongjae LEE^1,2, Woori KIM^1,2, Yujin JEONG^1,2, Suhyung CHO^1,2, Bernhard PALSSON^3,4,5, Byung-Kwan CHO^1,2,6,7 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ⁴Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁵Novo Nordisk Foundation Center for Biosustainability, Kongens Lyngby, Denmark, ⁶Intelligent Synthetic Biology Center, Daejeon, Korea, ⁷Innovative Biomaterials Research Center, KAIST Institutes, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP33	Cloning and Expression of Single-chain Variable Fragment Targeting Epidermal Growth Factor Receptor Seong Yong YOON¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP34	Gene Cloning, Expression, and Characterization of Anti-human Estrogen Receptor Alpha 36 Single Chain Fragment Variable Doo Young LIM¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP35	Cloning and Expression of C6.5 Single-chain Variable Fragment Targeting Human Epidermal Growth Factor Receptor Type2 Hye Min JO, Byeong Hee HWANG Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea

P0001	Magnetic Particle-based Aptamer Selection for the Detection of Various Analytes Myeongjune GO, Seung-Woon JUNG, Seung Min YOO School of Integrative Engineering, Chung-Ang University, Seoul, Korea
P0002	Highly Sensitive Gold Nanourchin for Rapid Bovine Coronavirus Detection Ruth STEPHANIE, Sung Hyun KIM, Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0003	Rosette-shaped Graphitic Carbon Nitride as a Highly Efficient Peroxidase Mimic for Glucose Biosensing Thinh Viet DANG¹, Yun Suk HUH², Moon Il KIM¹ ¹Department of BioNano Technology, Gachon University, Seongnam, Korea, ²Department of Biological Engineering, Inha University, Incheon, Korea
P0004	Continuous Synthesis of DMPC/DHPC Bicelle Using Hydrodynamic Focusing Micro-mixer and Analysis of Its Physicochemical Properties Bong Su KANG¹, Sung Hak CHOI², Kee Sung KIN³, Ho Sup JUNG², Moon Kyu KAWK¹ ¹School of Mechanical Engineering, Kyungpook National University, Daegu, Korea, ²Center for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University, Seoul, Korea, ³Research Inst. of Advanced. Materials, Collage of Engineering, Seoul National University, Seoul, Korea
P0005	Towards Reliable Marine Toxin Detection: Discovering Saxitoxin-specific Bioreceptor via Phage-display Technique So Yeon KWEON, Chan Yeong PARK, Ruth STEPHANIE, Sung Hyun KIM, Yeong Hyeock KIM, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0006	Screening of Aptamers Against Bst Polymerase for Increasing Reverse Transcriptase Activity Do-Young KIM¹, Woo-Ri SHIN¹, Simranjeet Singh SEKHON¹, Sang Yong KIM², Ji-Hyang WEE², Ji-Young AHN¹, Yang-Hoon KIM¹ ¹Major in Microbiology School of Biological Sciences College of Natural Sciences, Chungbuk National University, Cheongju, Korea, ²Department of Food Science and Biotechnology, Shin Ansan University, Ansan, Korea
P0007	Development of Cholesterol Detection Based on the Bienzyme Nanoparticle by Electrochemical Measurement Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0008	Effective Treatment for Cervical Cancer Through Folic Acid Modified Bovine Serum Albumin Nanoparticles Combining Chemo-photodynamic Therapy Suheon KIM¹, Hoomin LEE¹, Shruti SHUKLA², Vivek K. BAJPAI³, Young-Kyu HANC³, Yun Suk HUH¹ ¹Department of Biological Engineering, NanoBio High-Tech Materials Research Center, Inha University, Incheon, Korea, ²Department of Food Science and Technology, National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonipat, Haryana, India, ³Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, Korea
P0009	Co-encapsulation of Multiple Enzymes and Cofactors into Nanoparticles Seoungkyun KIM, Kiyoon KWON, Giyoong TAE, Inchan KWON School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
P0010	Fabrication of Electrochemical Aptasensor that Ag⁺ Ion Intercalated-DNA 3Way Junction on Micro-gap for Interferon Gamma Detection in Human Serum Seungwoo NOH, Taek LEE Department of Chemical Engineering, Kwangwoon University, Seoul, Korea
P0011	Development of Bioelectronic Nose Using Human Olfactory Receptor-embedded Nanodiscs for Diagnosing Gastric Cancer Dongseok MOON, Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea
P0012	Intein Spliced Di-nanoperforator with Higher and Broad-spectrum Anti-influenza Activity Seokoh MOON, Mi Soo KIM, Dae-Hyuk KWEON Department of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Korea
P0013	Fabrication of Electrochemical Biosensor for H1N1 Detection Jeongah PARK Kwangwoon University, Seoul, Korea

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로그인 주의사항
로그인 주의사항 1) 강연물에 대한 온라인 접속 권한은 2024년 4월 17~19일 동안 가능합니다. 2) 등록자에 한해서만 접속이 가능하고 아이디와 비밀번호를 타인과 공유하거나 알려주는 행위 등은 전면 금지됩니다. Q&A 주의 사항 3) 강연에 대한 질문은 ZOOM 채팅창에 이름/소속을 입력 후 작성해주시기 바랍니다. 강연물 저작 재산권법 4) 2024 한국생물공학회 춘계학술발표대회 및 국제심포지엄에 등록된 각종 자료는 저작권법으로 보호됩니다. 따라서 저작권법에 위반하여 각종 자료를 등록자 본인 외 제 3자에게 배포 및 전송, 복사하는 행위는 민·형사상 책임을 질 수 있으니 유의하시기 바랍니다. 위 사항을 모두 확인하셨으면 확인란에 체크해주시기 바랍니다.	확인
개인정보 활용 동의 (필수) 본 홈페이지는 등록자의 개인정보를 아래와 같이 처리함을 알려드립니다. 1. 개인정보의 수집·이용 목적 한국생물공학회에서 수집한 등록자 개인정보는 향후 학회 소식 및 홈페이지 이용권한을 위한 용도로만 활용되고 학회 참가기업의 등록자 정보 데이터를 확인하기 위하여 제공될 수 있습니다. 2. 수집하려는 개인정보의 항목 성명, 이메일, 휴대전화, 직책, 소속기관, 소속명 3. 개인정보의 보유 및 이용 기간 등록된 정보는 본 학회 종료일 이후 1년간 보유하며, 삭제 요청 시 요청자의 개인정보를 재생이 불가능한 방법으로 즉시 파기 합니다. 4. 개인정보의 제3자 제공 수집하는 개인정보를 목적 외의 용도로 이용하거나 제3자에게 제공하지 않습니다. 5. 권리 원칙적으로 개인정보 보호법에 의해 개인정보 수집 동의를 거부할 권리가 있습니다. 다만, 동의가 없을 경우 저작물 접근이 원활하게 진행되지 않을 수 있습니다. 본인은 개인정보보호법에 따라 위 각호 사항을 고지받고 개인정보 활용에 동의합니다.	동의