2023 한국생물공학회 춘계학술발표대회 및 국제심포지엄

Honorary Lecture by Biotech CEOs

Program

Speaker

[S2-1] Honorary Lecture by Biotech CEOs

Han-Oh Park

Plenary Lecture Ⅰ
Prof. Shuichi Takayama Georgia Institute of Technology USA H-index=81 Organoid, Cellchip, Organic chemistry Professor, GRA Eminent Scholar Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine	Background Dr. Shu Takayama earned his BS and MS in Agricultural Chemistry at the University of Tokyo. He earned a PhD in Chemistry at The Scripps Research Institute in La Jolla, California studying bio-organic synthesis with Dr. Chi‐Huey Wong. He then worked as a postdoc with Dr. George Whitesides at Harvard University where he focused on applying microfluidics to studying cell and molecular biology. Dr. Takayama began his career at the University of Michigan, where led his lab in the Department of Biomedical Engineering and Macromolecular Science & Engineering for over 17 years. In 2017, the lab moved to Georgia Tech where Shu became the Georgia Research Alliance Price Gilbert Chair Professor of Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering. Dr. Takayama’s research interests are diverse and motivated by clinical and biotechnology needs. He is always interested in hearing from stakeholders in these areas who are seeking engineering collaboration.

Plenary Lecture Ⅰ

Prof. Shuichi Takayama
Georgia Institute of Technology USA
H-index=81 Organoid, Cellchip, Organic chemistry
Professor, GRA Eminent Scholar
Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine

Background

Dr. Shu Takayama earned his BS and MS in Agricultural Chemistry at the University of Tokyo. He earned a PhD in Chemistry at The Scripps Research Institute in La Jolla, California studying bio-organic synthesis with Dr. Chi‐Huey Wong. He then worked as a postdoc with Dr. George Whitesides at Harvard University where he focused on applying microfluidics to studying cell and molecular biology.
Dr. Takayama began his career at the University of Michigan, where led his lab in the Department of Biomedical Engineering and Macromolecular Science & Engineering for over 17 years. In 2017, the lab moved to Georgia Tech where Shu became the Georgia Research Alliance Price Gilbert Chair Professor of Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering.
Dr. Takayama’s research interests are diverse and motivated by clinical and biotechnology needs. He is always interested in hearing from stakeholders in these areas who are seeking engineering collaboration.

Plenary Lecture Ⅱ
Prof. Ashutosh Chilkoti Duke University USA H-index=103 Colorimetric biosensor, Drug Delivery	Background Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University. My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery. Appointments and Affiliations Alan L. Kaganov Distinguished Professor of Biomedical Engineering Professor of Biomedical Engineering Research Professor of Global Health Professor in the Department of Chemistry Core Faculty in Innovation & Entrepreneurship Member of the Duke Cancer Institute Research Interests Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery. Awards, Honors, and Distinctions Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015 Fellow. National Academy of Inventors. 2014 Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013 Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011 Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011 Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010 Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008 Fellow. American Institute for Medical and Biological Engineering. 1996

Plenary Lecture Ⅱ

Prof. Ashutosh Chilkoti
Duke University USA
H-index=103 Colorimetric biosensor, Drug Delivery

Background

Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University.
My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.

Appointments and Affiliations

Alan L. Kaganov Distinguished Professor of Biomedical Engineering
Professor of Biomedical Engineering
Research Professor of Global Health
Professor in the Department of Chemistry
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Cancer Institute

Research Interests

Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery.

Awards, Honors, and Distinctions

Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015
Fellow. National Academy of Inventors. 2014
Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013
Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010
Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008
Fellow. American Institute for Medical and Biological Engineering. 1996

Plenary Lecture Ⅲ
Prof. Jens Nielsen Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden	Background Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering. Presentation Systems Biology of Yeast Metabolism Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅲ

Prof. Jens Nielsen
Department of Biology and Biological Engineering, Chalmers University of Technology,
Gothenburg, Sweden

Background

Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering.

Presentation

Systems Biology of Yeast Metabolism

Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅳ
Prof. Ron Milo Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel	Background Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics: Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals. Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity. Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food. Cell biology & Sustainability by numbers. http://book.bionumbers.org/ Presentation Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂ The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅳ

Prof. Ron Milo
Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel

Background

Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics:
Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals.
Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity.
Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food.
Cell biology & Sustainability by numbers. http://book.bionumbers.org/

Presentation

Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂

The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅴ
Prof. Jay D. KEASLING Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA	Background Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors Presentation Engineered Polyketide Synthases as Platform for Synthetic Chemistry Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅴ

Prof. Jay D. KEASLING
Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA
Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA

Background

Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors

Presentation

Engineered Polyketide Synthases as Platform for Synthetic Chemistry

Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅵ
Prof. Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea	Background Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology. Presentation Bioelectronic Nose for Odor Standardization Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

Plenary Lecture Ⅵ

Prof. Tai Hyun PARK
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea

Background

Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology.

Presentation

Bioelectronic Nose for Odor Standardization

Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

[S2-1] Honorary Lecture by Biotech CEOs
CEO & Chairman Han-Oh Park BIONEER Corporation	DNA Synthesis & Business Evolution Abstract With the invention of DNA synthetic chemistry in the early 1980s, an automatic synthesizer was developed and widely distributed globally. This has allowed the acceleration of the dissemination of genetic engineering technologies worldwide, such as gene recombination, PCR, and DNA sequencing. Starting from the deciphering of the human genome through the Genome Project in 1990, disease-related genetic information has accumulated exponentially over the past 30 years and a new era of disease diagnosis and treatment using genetic code information has begun with the development and distribution of Real-Time PCR and siRNA technology in the early 2000s. BIONEER Corporation commercialized and domesticated DNA synthesis technology and raw materials for the first time in Korea in 1992, as well as developed the world’s first 384-parallel oligo synthesizer in 2001 and also, established a global-scale oligo-manufacturing facility which resulted in the development of the human siRNA library and Real-Time PCR library. Moreover, BIONEER Corporation contributed to the 100% domestication of molecular diagnostic raw materials by developing various types of oligo-modifying materials. Furthermore, through the invention of SAMiRNA™ which is a self-assembling micellar interfering RNA nanoparticle, BIONEER Corporation has secured international competitiveness in the development of siRNA drugs and was able to develop CosmeRNA®, the world's first siRNA-based anti-hair loss functional cosmetics. References 1. Self-assembled Micelle Interfering RNA for Effective and Safe Targeting of Dysregulated Genes in Pulmonary Fibrosis, J Biol Chem, 2016 Mar 18;291(12):6433-46. 2. Four-Week Repeated Intravenous Dose Toxicity of Self-Assembled-Micelle Inhibitory RNA-Targeting Amphiregulin in Mice, International Journal of Toxicology, Vol. 40 issue 5, page(s): 453-465, July 2021 3. Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia, Scientific Report. 2022 Jan 31;12(1):1607 Keywords DNA·RNA Oligo, MDx (Molecular Diagnostics), siRNA, SAMiRNA, CosmeRNA

[S2-1] Honorary Lecture by Biotech CEOs

CEO & Chairman Han-Oh Park
BIONEER Corporation

DNA Synthesis & Business Evolution

Abstract
With the invention of DNA synthetic chemistry in the early 1980s, an automatic synthesizer was developed and widely distributed globally. This has allowed the acceleration of the dissemination of genetic engineering technologies worldwide, such as gene recombination, PCR, and DNA sequencing. Starting from the deciphering of the human genome through the Genome Project in 1990, disease-related genetic information has accumulated exponentially over the past 30 years and a new era of disease diagnosis and treatment using genetic code information has begun with the development and distribution of Real-Time PCR and siRNA technology in the early 2000s.

BIONEER Corporation commercialized and domesticated DNA synthesis technology and raw materials for the first time in Korea in 1992, as well as developed the world’s first 384-parallel oligo synthesizer in 2001 and also, established a global-scale oligo-manufacturing facility which resulted in the development of the human siRNA library and Real-Time PCR library. Moreover, BIONEER Corporation contributed to the 100% domestication of molecular diagnostic raw materials by developing various types of oligo-modifying materials. Furthermore, through the invention of SAMiRNA™ which is a self-assembling micellar interfering RNA nanoparticle, BIONEER Corporation has secured international competitiveness in the development of siRNA drugs and was able to develop CosmeRNA®, the world's first siRNA-based anti-hair loss functional cosmetics.

References
1. Self-assembled Micelle Interfering RNA for Effective and Safe Targeting of Dysregulated Genes in Pulmonary Fibrosis, J Biol Chem, 2016 Mar 18;291(12):6433-46.
2. Four-Week Repeated Intravenous Dose Toxicity of Self-Assembled-Micelle Inhibitory RNA-Targeting Amphiregulin in Mice, International Journal of Toxicology, Vol. 40 issue 5, page(s): 453-465, July 2021
3. Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia, Scientific Report. 2022 Jan 31;12(1):1607

Keywords
DNA·RNA Oligo, MDx (Molecular Diagnostics), siRNA, SAMiRNA, CosmeRNA

기관정보

기관명	한글	싸이티바 코리아	설립일	2019년 7월 1일
기관명	영문	Cytiva Korea	업종	도매 서비스 / 무역, 과학기자재, 진단시약 및 기자재, 오퍼
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		대표전화	02-6201-3800
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		홈페이지	www.cytivalifesciences.co.kr

주요 공적사항

Cytiva는 글로벌 공급자로서, 치료제의 개발 및 제조를 촉진하고 가속화하는 기술과 서비스를 제공하고 있습니다. 과거 GE Healthcare Life Sciences였던 Cytiva는 수십년을 거슬러 올라가는 풍부한 유산을 갖고 2020년부터 Cytiva 로 새롭게 시작했습니다. 우리의 고객은 기초 생물학적 연구에서부터 혁신적인 백신, 항체 및 재조합단백질의 바이오 의약품 및 새로운 세포 및 유전자 치료법 개발에 이르기까지 생명을 구하는 활동을 수행합니다. 우리의 임무는 그들이 더 나은 환경에서 더 빠르고 안전하게 일하는 데 필요한 도구와 서비스를 제공하여 더 나은 환자의 치료 결과를 이끄는 것입니다.
Cytiva는 글로벌 생명과학 리더로서, 삶을 변화시키는 치료법에 접근하여 인류의 건강을 증진시키고자 하는 비전에 전념하고 있습니다. Cytiva는 다양한 규모와 범위의 고객에게 신뢰할 수 있는 파트너로서, 연구 및 제조 워크플로우에 효율성을 제공하여 혁신적인 의약품의 개발과 제조, 그리고 환자에게 이를 전달하는 것을 보장합니다.

Cytiva Korea는 국내 바이오 기업들의 전문 기술력 육성에 대한 고민을 해결하는 데 도움을 주기 위해 <대한민국 바이오의약품 대상> 공모전을 후원하고 있습니다. 바이오의약품 개발 인프라 부족으로 어려움을 겪는 국내기업들을 대상으로 Cytiva의 제품과 패스트트랙센터 (Fast Trak Center)의 기술력을 함께 지원합니다. 배양/정제 공정 스크리닝, 공정 최적화, 공정 스케일업, 비임상시료 생산 등 제품 생산 전반에 걸쳐 제조공정 연구 및 양산에 도움을 드리려고 합니다.

대표기술

기술명	세포 배양 및 단백질 분리 정제를 위한 크로마토그래피 (chromatography) 기술

기술 개요

Cytiva만의 축적된 노하우를 바탕으로 바이오 의약품의 세포 배양/정제 공정 개발 및 스케일업, 분석법 개발, 기술이전, 미국 본사 cGMP 시설과 연계한 임상 시료 및 상업 생산을 지원합니다.
Cytiva의 목표는 특히 FAST TRAK center를 이용하여 고객이 직면한 공정상의 문제들을 해결하도록 도와주고 지원하는 것입니다.

기술 세부 내용

세포 배양의 기술은 싱글유즈 (Single-use) 장비를 이용한 바이오리액터 활용 및 업스트림 공정 개발 전략을 다룹니다. 공정 최적화 및 스케일-업을 위한 중요 변수 전반에 대한 것입니다. ReadyToProcess WAVE는 single-use bag 내부의 용액 움직임에 의한 믹싱 및 기체 전달 기능을 극대화한 single-use rocking bioreactor입니다. 세포 건강에 악영향을 주는 shear stress가 적고 single-use bag 사용으로 교차 오염 위험이 없어 연구 단계나 GMP 초기 종배양에 적합한 기술입니다.
Xcellerex bioreactor는 single-use 전문 브랜드로 바이오 의약품 개발, 생산 및 상용화 방식을 혁신하고 있습니다. 독창적인 바이오의약품 생산 플랫폼을 기반으로 구축된 혁신적인 single-use 어플리케이션 기술을 적용합니다.
단백질 분리 정제 (Protein purification)를 위한 기술과 방법의 개발은 생물공학분야에서 많은 발전을 위한 필수적인 전제조건이 되어져 왔다. 단백질 분리 정제는 간단한 one-step purification 과정에서부터 증명된 대량 정제의 생산 과정에까지 다양하다. 원하는 purity를 얻기 위해서는 종종 한번의 정제 과정 이상이 필요로 되어진다. 성공적인 단백질 정제는 적절한 technique을 선택하고, 그 방법으로 최상의 결과가 나오도록 optimization 하고, 수율 (yield)은 최대로 얻고 요구되는 정제 단계를 최소로 하는 것이다. 대부분의 단백질 정제는 크로마토그래피 (chromatography) 방법을 포함한다. 그 결과로 크로마토그래피는 단백질 정제를 위한 가장 필수적인 기술이다.

기술활용 범위

바이오 공정의 재조합 단백질, 항체, 백신 개발 및 생산을 위한 세포 배양 및 단백질 정제를 위한 분야에 폭넓게 사용되고 있으며, 또한 유전자 및 세로치료제 분야에 있어서도 배양 및 정제 기술을 활용하는 연구 및 생산에 적용되고 있습니다.

[S2-3] 학술대상 수상기념특강
Jeewon LEE Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV	Optimally Fabricated Platforms for Enhanced Cancer Therapy Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

[S2-3] 학술대상 수상기념특강

Jeewon LEE
Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV

Optimally Fabricated Platforms for Enhanced Cancer Therapy

Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

Commercializing Biotechnology

Instruction

Biotechnology is the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services. With advances in biotechnology, there has been a growing interest in commercializing these technologies to bring new products to market. Commercialization of biotechnology refers to the process of turning research and development into marketable products that can generate revenue and profits for businesses. In this session, we will discuss recent developments in the biotechnology industry, focusing on real-world opportunities and challenges.

Professor Kyungmoon PARK

Hongik University, Korea

	Keynote Speaker A Next Generation Biotech Platform for the Sustainable Future Executive Vice President So Young KimBio Business Unit, CJ CheilJedang, Korea
	Invited Speaker DAESANG Corporation's Bio Ingredient business and Green Bio research Team Manager Suoksu KimIngredient R&D Institute, DAESANG, Korea
	Invited Speaker GS Caltex’s R&D for 2,3-Butanediol Production and Industrial Application Team Leader Bae Kun Shin GS Caltex R&D Center, Daejeon, Korea
	Invited Speaker Antibody Platform Technology Team Leader Dong-Sik Kim GC Biopharma, Yongin, Korea

Recent Trends in the Development of Therapeutic Biologics

Instruction

Designing and engineering new biologics has played essential roles in developing novel therapeutics and expanding the scope of medicine. This session covers representative works of developing next-generation therapeutic biologics against various diseases. The first speaker (Prof. Kim) presents an innovative approach to using endogenous virus-specific CD8+ T cells for cancers based on tumor-specific cytosol-penetrating antibodies. Prof. Jung describes various antibody Fc variants his group has developed so far, which can endow superior functions to antibody therapeutics. Then, Prof. Van Deventer presents a new platform technology to discover crosslinkable antibodies and its application in developing inhibitors against a Botulinum Neurotoxin target. The last speaker (Prof. Lee) presents the analysis results of antibody repertoires to influenza and SARS-CoV-2 and shows how they can be used in engineering antibodies and vaccines.

Professor Tae Hyeon Yoo

Ajou University, Korea

	Keynote Speaker Immunocytokines as Emerging Therapeutics for Cancer Immunotherapy: Focusing on IL-12 Immunocytokine Professor Yong-Sung KimAjou University, Korea
	Invited Speaker Palette of Antibody Fc Variants That Enable Therapeutic Potency Boosting, Effector Function Silencing, or Circulating Half-Life Extension Professor Sang Taek JungKorea University, Korea
	Invited Speaker Covalent Antibody Discovery on the Yeast Surface Against a Botulinum Neurotoxin Target Professor James A. Van DeventerTufts University, USA
	Invited Speaker An Immunoproteomic Survey of the Antibody Landscape: Insights and Opportunities Revealed by Immune Repertoire Profiling Professor Jiwon Lee Dartmouth College,USA

Co-organized by

Synthetic Biology of Secondary Metabolite Producers for Drug Discovery and Development

Instruction

Synthetic biology and metabolic engineering together with related principles and technologies endeavor to redesign and optimize the genetic and regulatory processes of various organisms for our society's sake. In this session, we will discuss recent advances in synthetic biology of secondary metabolite producers with an emphasis on small molecules with human benefits.

Professor Dokyun Na

Chung-Ang University, Korea

	Keynote Speaker Leveraging a Large Actinobacterial Strain Collection for Natural Product Biosynthesis, Engineering, and Drug Discovery Professor Ben ShenUF Scripps Biomedical Research, USA
	Invited Speaker Multi-engineering of microbial cytochrome P450 enzymes Professor Shengying LiShandong University, China
	Invited Speaker Characterization and Engineering of Microbial Small Molecule Biosynthesis for Drug Discovery Professor Yeo Joon YoonSeoul National University, Korea
	Invited Speaker Production of natural sunscreen materials in yeasts Professor Ji-Sook Hahn Seoul National University, Korea
	Invited Speaker Systems Metabolic Engineering for the Enhanced Production of Secondary Metabolites Professor Hyun Uk Kim KAIST, Korea

Antibody Engineering and Cell Culture Engineering

Instruction

The current status of antibody drug research and bioprocess development from top-tier scientists who are most active at the forefront of academia and industry in relation to antibody drug development will be presented. The main topics of discussion are antibody engineering, biologics development, cell culture engineering, and biomanufacturing including media development. It will be an influential forum for leaders and experts from academic and industrial backgrounds to convene and discuss antibody engineering, cell culture engineering, and the related advancements that impact a growing spectrum of modalities including recombinant biologics and downstream processing. Various discussions between academia and industry on related topics will be held.

Professor Soonjo Kwon

Inha University, Korea

Professor Jae Seong Lee

Ajou University, Korea

	Keynote Speaker Demands of secreted protein products - systems biology improve quality and titer of biologics Professor Johan RockbergKTH Royal Institute of Technology, Sweden
	Invited Speaker Real-time monitoring and multi-scale modeling for bioprocess Digital Twin systems toward biomanufacturing 4.0 Professor Dong-Yup LeeSungkyunkwan University, Korea
	Invited Speaker Maximizing performance of your biologics pipeline: Media and process optimization using cutting-edge tools Chief Scientist Yaron SilberbergAjinomoto Genexine, Co., LTD., Korea
	Invited Speaker Stereospecific interactions between histidine and monoclonal antibodies Professor Youngbin Baek Inha University, Korea

Co-organized by

Biosensing Technology & Cell Engineering I

Instruction

This section invites key researchers with expertise in the fields of Biosensing Technology & Cell Engineering. In this symposium, we will discuss Biosensing strategies for developing sensitive biosensors to detect diseases and cell engineering for therapeutics. Speakers present the leading-edge trends and technologies in these fields with a special focus on the applications and developments of biosensor, nanomedicine, stem cell engineering, and tissue engineering. (This symposium is supported by Institute of Integrated Biotechnology and the BK21 Four MCCBE Research Team in Sogang university)

Professor Jeong-Woo Choi

Sogang University, Korea

	Keynote Speaker Innovative Biosensing Technologies to Realize Continuous, Real-time, In Vivo Monitoring Systems Professor Koji SodeUniversity of North Carolina and North Carolina State University, USA
	Keynote Speaker Engineering organoids for regenerative medicine and drug discovery Professor Seungwoo ChoYonsei University, Korea
	Invited Speaker Label-free Detection of Transport Kinetics and Inhibitor Binding of Membrane Transport Proteins with a Two-mode Plasmonic Sensor Professor Ling ChaoNational Taiwan Univeristy, Taiwan
	Invited Speaker Ultrasound Detection of Microcalcification for Early Detection of Breast Cancers and Differential Diagnosis Professor Yangmo Yoo Sogang University, Korea

Biosensing Technology & Cell Engineering II

Professor Taewook Kang

Sogang University, Korea

	Keynote Speaker Biosensor Integrated Internet of Things for Infectious Disease Point of Care Testings Professor Chenzhong Li Tulane University School of Medicine, USA
	Keynote Speaker Cutting-edge technologies for isothermal molecular diagnostics of COVID-19 Professor Hyun Gyu ParkKAIST, Korea
	Invited Speaker Aptameric enzyme subunit for homogeneous detection enabling in situ detection Professor Kazunori IkebukuroTokyo University of Agriculture and Technology, Japan
	Invited Speaker Electrochemical Nanobiosensor for Detection of Viral RNA and Its Mutation Derivative Using Nanoporous Electrode Array (NPEA) Professor Jinho Yoon The Catholic University of Korea, Korea

Co-organized by

Circadian Rhythm and Human Health

Instruction

This special symposium introduces cutting-edge researches focused on the relationship between circadian rhythm and human health. The aim of the special session is to further enhance our understanding of the circadian rhythm topic by inviting 3 prominent speakers who are conducting the state-of-the-art researches on the subject in the United States, Japan, and Korea. Additionally, we will introduce/discuss the research direction of BCA2-RLRC (Biological Clock-based Anti-Aging Convergence Regional Leading Research Center), which was recently launched with the support of the National Research Foundation of Korea.

Professor Seung Pil Pack

Korea University, Korea

Professor Jin Hyub Lee

Korea University, Korea

	Invited Speaker Circadian Rhythm and Human Health: Researches of BCA2-RLRC Professor Seung Pil PackKorea University, Korea
	Keynote Speaker Emerging Links between Circadian Disruption and Cancer Risk Professor Katja A. LamiaScripps Research, USA
	Invited Speaker Towards Systems Biology of Human Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep Professor Hiroki R. UedaThe University of Tokyo, Japan
	Invited Speaker Suprachiasmatic VIP Neurons Control Circadian Priority of Social Instincts Professor Han Kyoung ChoiDGIST, Korea

Co-organized by

LNP/mRNA Therapeutics

Instruction

The session presents the current research trend on the development of lipid nanoparticle and mRNAs for therapeutic purposes. Professor M.J. Mitchell is an expert on developing novel lipid nanoparticles and applying immunoengineering for the delivery of mRNA therapy. In addition, Professor Hyun Jung Chung from KAIST is also an expert in designing lipid nanoparticles for gene delivery. The last two speakers of the session Professor Kyuri Lee and Professor Jinkuk Kim are experts in RNA therapeutics.

Professor Hyun Jin Kim

Inha University, Korea

Professor Yoosik Kim

KAIST, Korea

	Invited Speaker Lipid Nanoparticles for Overcoming Biological Barriers to Nucleic Acid Delivery Professor Michael J. MitchellUniversity of Pennsylvania, USA
	Invited Speaker Reinforcing Nanoformulations via Chemical Tailoring for in vivo Gene Editing and Delivery Professor Hyun Jung ChungKAIST, Korea
	Invited Speaker Development of RNA structures for cancer immunotherapy Professor Kyuri LeeGyeongsang National University, Korea
	Invited Speaker Antisense oligonucleotide (ASO) as an artificial non-coding RNA to treat diseases Professor Jinkuk KimKAIST, Korea

Co-organized by

BEST-SBJ-KSBB Joint Session I

Instruction

This session presents the joint symposium of Korea-Japan-Taiwan Biotechnology and Bioengineering Societies. A total of eight speakers representing each of the three participating countries will present recent research trends in the community. The presentation will cover a range of topics from traditional microbial engineering to biomedical engineering.

Professor Youngeun Kwon

Dongguk University, Korea

ProfessorYun Jung Heo

Kyung Hee University, Korea

	Invited Speaker Valorization of Spent Mushroom Substrate (SMS) for Circular Bioeconomy Professor Yoong Kit LeongTunghai University, Taiwan
	Invited Speaker Optogenetic approaches for efficient microbial bio-productions Professor Yoshihiro ToyaOsaka University, Japan
	Invited Speaker Development of Tumor Microenvironmental-response Nanoparticles for Effective Cancer Treatment Professor Yun Suk HuhInha University, Korea
	Invited Speaker A New Way of Using Spent Coffee Grounds: Photothermal materials Professor Hsiu-Wen ChienNational Kaohsiung University of Science and Technology, Taiwan

BEST-SBJ-KSBB Joint Session II

Professor Yoosik Kim

KAIST, Korea

ProfessorSeung Pil Pack

Korea University, Korea

	Invited Speaker Artificial lipidation for biomolecular engineering at biointerface Professor Noriho KamiyaKyushu University, Japan
	Invited Speaker Membrane dynamics and its application to biotechnology Professor Masahiro TakagiJapan Advanced Institute of Science and Technology, Japan
	Invited Speaker Cyclic Breathing Lung Inflammation Model for Pulmonary Drug Screening Professor Jen-Huang (Tony) HuangNational Tsing Hua University, Taiwan
	Invited Speaker RNA-based predictive marker for chemotherapy Professor Yoosik KimKorea Advanced Institute of Science and Technology, Korea

Co-organized by

Biochemical Carbon Capture and Transformation

Instruction

A crucial agenda facing humanity today is the creation of a carbon-neutral society. Interest in green biotechnology and chemistry that enable sustainable development is rising amid the net-zero movement. This presentation covers the most recent developments in biochemical technologies for carbon capture and transformation. Additionally, a thorough discussion of the future course will be held.

Professor Junhyeok Seo

GIST, Korea

	Keynote Speaker Open-shell Reactivity of a Nickel(I) Species Related to the CODH Organometallic Reactions Professor Yunho LeeSeoul National University, Korea
	Invited Speaker Cofactor Swing Arm Mediated CO2 Reduction Using co-Immobilized Enzymes Professor Inchan KwonGIST, Korea
	Invited Speaker Material-biology Hybrids for the Fixation of CO2 and N2 from Solar Energy Professor Chong LiuUniversity of California, USA
	Invited Speaker Electrocatalytic CO2 and Proton Reactivities of High-Valent W(IV)-Oxo Bis(dithiolene) versus Low-Valent Co(II) Complexes Professor Junhyeok Seo GIST, Korea

Co-organized by

Plastic Up-cycling Technology for Sustainable Society

Instruction

The word "plastic" originates from the Greek word "plastikos," which means "capable of being molded or shaped." Over the past century, humanity has been fortunate to enjoy the abundance of plastic, a dream material that is easy to shape and has excellent properties, in various forms at very affordable prices. As a result, plastic has been used extensively on a large scale. Usage has increased dramatically, from 2 million tons annually in 1950 to 407 million tons annually in 2015, a more than 200-fold increase, and the market has reached astronomical proportions of over $1 trillion (1,200 trillion won) as of 2015. If the current trend continues, plastic production is expected to increase to approximately 1,124 million tons by around 2050.

However, the indiscriminate disposal of mass-produced/consumed plastic without proper recycling or treatment has become a threat to the natural environment, as well as ecosystem disruption and human life. Therefore, it is urgent to develop upcycling technology for plastic to prevent its indiscriminate disposal and to achieve a sustainable society. In this session, we aim to introduce and discuss the latest trends in plastic upcycling technology with domestic and international experts.

Professor Yong Hwan Kim

UNIST, Korea

Professor Sang Hyun Lee

Konkuk University, Korea

	Keynote Speaker Biological and Chemical Strategies for the Valorization of Plastic Waste Senior Research Fellow and Group Leader Gregg T. Beckham National Renewable Energy Laboratory, USA
	Invited Speaker Bio-recycling of PET plastic Professor Kyung-Jin Kim Kyungpook National University, Korea
	Invited Speaker Electrochemical Approaches for Biomass Reforming Professor Jungki Ryu UNIST, Korea
	Invited Speaker Accelerated Degradation of Sequence-defined Polylactides Professor Kyoung Taek Kim Seoul National University, Korea

Co-organized by

Engineering the Future of Food: Innovations in Protein Design and Microbial Metabolism

Instruction

Over the past several decades, advances in biotechnology have transformed the way we produce, process, and consume food. From genetically modified crops to cultured meat, biotechnology has the potential to revolutionize our food systems and help us address some of the world's most pressing challenges, from food security to environmental sustainability. This session will explore the latest developments in food biotechnology and their implications for the future of food. We'll hear from leading experts in the field about the potential benefits and risks of different biotechnological approaches. Whether you're a scientist, a policymaker, a food industry professional, or simply a curious consumer, we hope you'll find this session informative and thought-provoking.

Director Daehee Lee

KRIBB, Korea

Professor Soo-Jung Kim

Chonnam National University, Korea

	Keynote Speaker Design Principles for Sustainable Chemistry: A Theoretical and Machine Learning Approach Professor Seonah KimColorado State University, USA
	Invited Speaker Protein Design of the Stevioside Converting Enzyme UGT76 for Improved Activity and Stability Principal Researcher Eui-Jeon WooKRIBB, Korea
	Invited Speaker Microbial Production of 2'-fucosyllactose and Its Potential Applications Professor Jae Won Lee Sungshin Women’s University, Korea
	Invited Speaker Biological Conversion of Renewable Biomass into High-valued Products with Microbial Synthetic Biology Researcher Jonghyeok Shin KRIBB, Korea

Co-organized by

Advances in Design and Delivery of Biotherapeutics

Instruction

This session will explore the recent advancements in the development of biotherapeutic agents for the treatment of various diseases. The session will cover various topics, including the design of biotherapeutics with improved efficacy and specificity, the use of innovative delivery systems to enhance biotherapeutic targeting and effectiveness, and the optimization of biotherapeutic manufacturing processes to ensure high quality and consistency. The session will also discuss current challenges in the field of biotherapeutics and the strategies being developed to overcome them. Topics to be covered in this session include the challenges associated with the delivery of biotherapeutic agents, the need for new technologies to ensure the prolonged circulation time or targeted delivery of biotherapeutics.

Professor Inchan Kwon

GIST, Korea

	Keynote Speaker The strategy to Treat Pan-KRAS Mutant Cancers by Using Albumin Binding Caspase-3 Cleavable Peptide-drug Conjugate Professor Youngro ByunSeoul National University, Korea
	Invited Speaker Development of Gout Treatment Using SelecAllTM, a Novel Platform Technology That Couples Albumin Molecules to Biomolecules Containing Unnatural Amino Acids (UAAs) Using Linkers through Click Chemistry (SPAAC or IEDDA) CEO Jeonghaeng ChoProAbTech Co., Ltd., Korea
	Invited Speaker pH-Responsive Cleavable Protein Linker for Selective Delivery of Protein Pharmaceuticals Professor Yan LeeSeoul National University, Korea
	Invited Speaker Tolerogenic Nanoparticle Vaccine to Induce Antigen-Specific Immune Tolerance for Treating Multiple Sclerosis Professor Jaeyun Kim Sungkyunkwan University, Korea

Co-organized by

Synthetic Biology for Healthy and Sustainable Future

Instruction

Synthetic biology endeavors to redesign and to optimize genetic and regulatory processes of various organisms to build our future healthier and sustainable. In this session, we will discuss synthetic biology and metabolic engineering approaches to solve problems in energy, pharamaceuticals, and chemicals manufacturing with five eminent speakers in the fields.

Professor Jeong Wook Lee

POSTECH, Korea

	Keynote Speaker Innovative Approaches to Creating Smart Cells for Bioproduction Professor Akihiko KondoKobe University, Japan
	Keynote Speaker Engineering Microbial Systems for Isoprenol Production, a Precursor of Sustainable Aviation Fuel Director/Staff Scientist Taek Soon LeeJoint BioEnergy Institute/Lawrence Berkeley National Laboratory, USA
	Invited Speaker Ribosome-mediated Biosynthesis of Pharmacophore Professor Joongoo Lee POSTECH, Korea
	Invited Speaker Biosynthesis of Aromatic Natural Products from Metabolically Engineered Escherichia coli Professor Dongsoo YangKorea University, Korea
	Invited Speaker Current Status and Challenges for National Synthetic Biology Innovation Director Hyojin RyuMinistry of Science and ICT, Korea

Biocatalysts for the Lifecycle of Bioplastic - From Synthesis to Upcycling

Instruction

Many different methods are applied to the synthesis, degradation and upcycling of bioplastics. Among them, biocatalysts draws the most attention because only biocatalysts meets the criteria of carbon-neutral era. However, biocatalysts from nature often needs to get additional fit and robustness for the application to synthesis, depolymerization and upcycling of bioplastics. This session gives recent research and future perspectives in the biological synthesis, degradation and upcycling of bioplastics.

Professor Jin-Byung Park

Ewha Womans University, Korea

Professor Joo-Hyun Seo

Kookmin University, Korea

	Keynote Speaker Plastics as Carbon Source for Microbial Bioplastics Professor Lars BlankRWTH Aachen University, Germany
	Invited Speaker Chemical and Enzymatic Depolymerization of PET for One-pot Upcycling Professor Kyoung Heon KimKorea University, Korea
	Invited Speaker Biocatalytic Depolymerization of Poly(butylene-adipate-co-terephthalate) (PBAT) for Upcycling Professor Sang-Hyun PyoLund University, Sweden
	Invited Speaker Biodegradation of Plastics by New Biocatalyst and Their Potential Biochemical Pathway Professor Soo-Jin YeomChonnam National University, Korea

Innovative Bioprocess Engineering

Instruction

Cell and antibody therapeutics have been developed and commercialized through long and sophisticated bioprocess engineering. The process contains basic research, translational research, and mass production in various fields. In this international session, we invite speakers working on state-of-the-art bioprocesses for biopharmaceutical manufacturing and will share the inspiration from the speakers.

Professor Jong Youn Baik

Inha University, Korea

Professor Hyun Jin Kim

Inha University, Korea

	Invited Speaker Development of Cell Engineering Technology for Creating Functional Animal Cells Professor Masamichi KamihiraKyushu University, Japan
	Invited Speaker The QbD Approach for Manufacturing Stem Cell-derived Artificial Red Blood Cells Principal Researcher Won-Seok ChoiOsong Medical Innovation Foundation, Korea
	Invited Speaker Accelerated High-performing Upstream Process of Monoclonal Antibody: Upstream Optimization Case Study Dr. Sojeong LeeSamSung Biologics, Korea
	Invited Speaker Modeling of Skeletal Development Using Human Pluripotent Stem Cells and Exploring the Gene Regulatory Networks Professor Hironori HojoUniversity of Tokyo, Japan

Co-organized by

유전자변형생물체의 산업적 활용 활성화를 위한 정보공유 및 의견수렴

Instruction

이 세션은 연구 후 논문 발표나 특허 출원 수준에만 머물고 있는 유전자변형생물체 및 유래 산업용산물이 위해성심사 장벽을 넘어 사업화까지 갈 수 있도록 제도개선, 인프라구축 및 연구개발을 지원하는 “바이오위해평가 원팀 리노베이션사업(2021-2023)”의 성과를 소개하고 관련 이해당사자들의 의견을 청취하는 것을 목적으로 구성되었음.

효율적이고 일관적인 유전자변형생물체 위해성평가와 안전관리를 위해 개발된 내용들을 적극 공유하고 관심을 가진 학계 및 산업계 관련자들의 의견들을 반영하여 정부의 화이트바이오산업 활성화와 탄소중립 추진을 뒷받침할 수 있을 것으로 기대됨.

교수이한길

충남대학교

	Invited Speaker 바이오위해평가원팀리노베이션사업 소개 김기철 센터장한국생명공학연구원
	Invited Speaker 산업용 LMO 및 제품의 해외진출지원을 위한 해외 인허가 지원 시스템 소개 김일권 교수경북대학교
	Invited Speaker 산업용 LMO 위해성정보시스템 소개 김아영 연구원㈜포도
	Invited Speaker 산업용 LMO위해성심사 신청자용 가이드라인 이한길 교수충남대학교
	신청자용 가이드라인(안) 및 정보제공 데이터페이스 등 관련 공청회 좌장: 이한길, 패널: 연사 - 김기철, 김일권, 김아영

Co-organized by
바이오위해평가원팀리노베이션사업 제2세부과제

Sponsored by

Young Scientist Forum I

Instruction

This Young Scientist Forum will cover the state-of-the-art technologies in biomaterials-mediated engineering applications. Especially, (1) polymeric materials-based targeted therapeutics & diagnonstics, (2) polymeric delivery platform, and (3) biomaterial-based cancer vaccine, and (4) sensor arrays will be discussed in this session.

ProfessorSungho Jang

Incheon National University, Korea

	Nano and Microscale Polymer Conjugates for Targeted Therapeutics and Diagnostics Invited Speaker Professor Yoo Kyung KangGyeongsang National University, Korea
	Polymeric Delivery Platforms for Biomedical Applications Invited Speaker Professor Hyemin KimKonkuk University, Korea
	Biomaterials-based cancer vaccine strategy for precision cancer medicine Invited Speaker Professor Sejin SonInha University, Korea
	Blood-compatible Bioelectrical & Chemical Sensors Array for Measuring the Distribution of Biometric Information Invited Speaker Senior Researcher Wonryung LeeKIST, Korea

Young Scientist Forum II

Instruction

The goal of this Young Scientist Forum is to highlight current developments in disease treatment/detection and microbial engineering, that focus on (1) bioadhesive-based medical divice design strategy, (2) bioelectronics , and (3) genome/transcriptome analyses

ProfessorJunehyung Kim

Dong-A University, Korea

	Smart Bioadhesives Based on Multiscale Mechanical Design for Versatile Medical Devices Invited Speaker Professor Sangyul BaikSungkyunkwan University, Korea
	Biocompatible and Tissue Adhesive Soft Electronics for Electroceuticals Invited Speaker Professor Kang-Il SongPukyong National University, Korea
	Wearable and Implantable Bioelectronics Invited Speaker Professor Sanggil HanIncheon National University, Korea
	Large-scale Genome and Transcriptome Analyses for Microbial Host Engineering Invited Speaker Professor Hyun Gyu LimInha University, Korea

Special Session of White Biotechnology for Platform Chemical Productions

Instruction

White Biotechnology uses renewable resources or uses microorganisms and enzymes to replace materials in the existing chemical and energy industries with more sustainable bio-based technologies. The petrochemical industry is entering the white bio business with low carbon emissions in accordance with the global carbon neutrality declaration, full-fledged environmental, social, and governance (ESG) management, and plastic regulations. In this session, we will discuss the recent development of technology and practical application status with domestic academic and industry experts on white bio technology.

ProfessorJung Rae Kim

Pusan National University, Korea

	Invited Speaker Production of Biofuels and Biochemicals from CO2 Using Microalgae Professor You-Kwan OhPusan National University, Korea
	Invited Speaker Methane Bioconversion Using Methanotrophs for the Production of Biopolymers Professor Eun Yeol LeeKyung Hee University, Korea
	Invited Speaker Microbial Synthetic Biology for Industrial Biotechnology Professor Gyoo Yeol JungPOSTECH, Korea
	Invited Speaker Enzymatic Conversion of C1 Gas for Carbon Neutral and Sustainable Industry Professor Yong Hwan KimUNIST, Korea
	Invited Speaker White Biotechnology Journey at GS Caltex Assistant Vice President of White Bio Development Center Hyohak SongGS Caltex, Korea
	Invited Speaker Concluding Remark Professor Sunghoon ParkUNIST, Korea

Co-organized by

Bio Medical Cluster and Education of Future Human Resources in Hwasun Bio-Medicine Industrial Complex

Instruction

We would like to introduce the present and the future of biomedical cluster and human resources training in Hwasun Bio-Medicine Industrial Complex. This is composed of organizations of the biomedical cluster located in Hwasun Bio-Medicine Industrial Complex, the characteristics of each unit center, and technical practices and field practices necessary for human resources training. This session will introduce opportunities that can improve practical ability and put to practical use to participating students and researchers. Also it will introduce educational opportunities to participate in the manpower training program of the Jeonnam Biomedical Cluster which can cover the entire cycle of biopharmaceutical development

DirectorKang Ryu

Jeonnam Biopharmaceutical Research Center, Korea

	A Proposal for Ultra-Mega biomedical Cluster and Talent Development to Enhance Competitiveness in the Korean Biomedical Industry Invited Speaker Professor Hyung-Seok KimChonnam National University Hwasun Hospital, Korea
	The Role of the Vaccine Safety Technology Support Center for the safety and commercialization of vaccines. Invited Speaker Senior Researcher Soo-Na ChoVaccin Center for Assinstin Safety & Technology, Korea
	Instruction for PCMO(Public CMO for Microbial-based Vaccine) Invited Speaker Team Manager Kook Heon SeoPCMO, Korea
	An Overview of Biomedical Clusters in Hwasun Vaccine Industry Zone Invited Speaker Team Manager Mi Gyung LeeHwasun-gun, Korea

Co-organized by

Sponsored by
전라남도/화순군

Nanobio Technology of Diagnostics for Health and Future Bioindustry

Instruction

Nanobiotechnology currently have been providing a critical platform for health-cares and it will support sustainable bioeconomy in near future. In this session, state of arts nanobiotechnology including nanovesicle, nanoparticle, and nanocluster will be introduced for diagnostic tools for futuristic biotechnology.

ProfessorHyun Ho Lee

Myongji University, Korea

	Invited Speaker C. elegans for Innovative Healthcare and Drug Discovery Professor / CEO Shin Sik ChoiMyongji University, Korea / (주)엘렉스랩
	Invited Speaker Synthesis of Surface Engineered Nanocrystals for Biological Applications: Bioimaging and Biosensors Professor Jongnam ParkUNIST, Korea
	Invited Speaker Active Site Engineering of Nanozymes for Biosensing and Beyond Professor Moon Il KimGachon University, Korea
	Invited Speaker Improved PCR Strategies for Disease Diagnosis professor Cheulhee JungKorea University, Korea

Energy and Environmental Biotechnology

Instruction

Hydrogen is emerging as an important reducing agent in the supply of eco-friendly automotive fuel cells and the pharmaceutical and cosmetics industries, steel, and various industrial applications, thus due to its increase of demand, it is urgent to develop technologies accordingly. In this session, we will look at the recent development of technologies and practical applications with experts from academia and industry on the production of eco-friendly biohydrogen production.

ProfessorJung Rae Kim

Pusan National University, Korea

	Invited Speaker Biohydrogen Production and Purification: Focusing on Bioelectrochemical Systems Professor Hyung Sool LeeKorea Institute of Energy Technology (KENTECH), Korea
	Invited Speaker Recent Development and Perspective of Fermentative Hydrogen Production Professor Sang-Hyoun KimYonsei University, Korea
	Invited Speaker Bioelectrochemical Hydrogen Production Using Syntrophic Interaction between Fermentative and Electroactive Bacteria Principal Researcher Joo-Youn NamKorea Institute of Energy Research, Korea
	Invited Speaker Pilot-Scale Studies of a Novel Type Hydrogen-Producing Microbial Electrolysis Cells (MECs) Reactor Treating High-Strength Organic Wastes Senior Managing Director & Chief Technology Officer Dae-Yeol Cheong BioX, Inc., Korea

Co-organized by

Sponsored by
한국환경산업기술원, 한국연구재단, 중소기업기술정보진흥원, 연세대학교

Trends in Bioprocess Development in Industrial Biotechnology for Market Penetration

Instruction

In accordance with the global carbon reduction policy, the chemical industry is required to undergo structural changes to a sustainable platform. As one of the solutions to this, industrial biotechnology has been in the limelight. Industrial biotechnology refers to biotechnology that produces fuel, energy, and chemicals by using renewable biomass as a raw material instead of petroleum or by using enzymes or microorganisms in the production process. As interest in the development of biochemical products has recently increased in Korea, this session presents the recent trend of bioprocess development in the field of industrial biotechnology. In-depth discussions on the future directions for the commercialization will also be held.

ProfessorSeung Hwan Lee

Chonnam National University, Korea

	Invited Speaker Bio-dodecanedioic Acid by Microbial Biotransformation of Plant Oil-derived Resources and Its Application in Polyamide 6.12 Research Engineer Wooyoung JeonKorea Research Institute of Bioscience & Biotechnilogy, Korea
	Invited Speaker Development of Mass Production Technology of Lactobionic Acid as a Cosmetic Ingredient Using Eco-friendly Fermentation Process Principal Researcher Gyeong Tae EomKorea Research Institute of Chemical Technology, Korea
	Invited Speaker Development of Microalgal Bioprocess for the Production of Value-added Products from CO2 Assistant Professor Nam Kyu KangKyung Hee University, Korea
	Invited Speaker Development of Novel Ingredient from Microalgae for Aquaculture Market Project Leader Jiyoung KimCJ Cheiljedang, Korea

Advances in Macroalgal Biorefinery

Instruction

Plastics produced through petroleum-based processes are a major contributor to global warming and microplastics. To address this, an ongoing effort is to introduce bioplastics as an alternative to petroleum-based plastics. Current bioplastic production processes utilize mostly terrestrial biomass, which raises ethical and economic concerns. Algal biomass is gaining attention as an alternative feedstock that can overcome these problems. In particular, the production of macroalgae is increasing in Asian countries including Korea. However, to commercialize the bioplastic production process using macroalgae, it is necessary to develop a direct utilization process that omits the macroalgae pretreatment process which increases the overall process cost. This session will introduce the new technologies required to develop a process that directly utilizes macroalgae.

ProfessorSungho Jang

Incheon National University, Korea

	Invited Speaker Engineering of Vibrio sp. dhg, a Novel Host Strain for Macroalgal Biorefinery Professor Gyoo Yeol JungPOSTECH, Korea
	Invited Speaker High-value Products from Various Biomass Feedstock Professor Chulhwan ParkKwangwoon University, Korea
	Invited Speaker Improving the Activity of Malonyl Coenzyme A Reductase via Computational Design Tools Professor Sung In LimPukyong National University, Korea
	Invited Speaker A Synthetic Biology Tool for the Macroalgae-metabolizing Bacterium Professor Jina YangJeju National University, Korea

Co-organized by

[S7-2] TWISTBIOSCIENCE 런천세미나 II
Novel strategies towards enhancing enzymatic properties such as catalytic activity, specificity and stability have opened up a plethora of novel applications for industrial production, agriculture and sustainability. Such improved enzymes are typically identified in high throughput functional screening campaigns by either investigating the vast number of naturally occurring microbial homologs or by exploring the synthetic combinatorial space of given amino acid motifs. Both strategies rely on the ability to generate high numbers of DNA templates. At Twist Biosciences we have revolutionized DNA synthesis in terms of scale, uniformity and error rate. The resulting high-quality products such as clonal genes and DNA variant libraries comprise the ideal basis for high throughput functional screenings for enhanced enzyme variants. In this seminar we will give an introduction to Twist Bioscience, our products and show how we change the game of enzyme engineering.
Speaker	Affiliation	Title
	Bernd Willems, Ph.D. Libraries and SynBio Application Specialist Twist Bioscience	Twist Bioscience–Writing the Future of Enzyme Engineering

[S7-3] Molecular Devices 런천세미나 III
For the synthetic biologist, biological building blocks are often generated from bacteria. The design-build-test process is utilized in order to engineer these building blocks. This often requires screening and picking colonies of interest. Traditionally, colony picking is performed manually using sterile pipette tips, toothpicks, or inoculation loops, which is a slow, labor-intensive, and time consuming process. Synthetic biology research can, therefore, benefit greatly from the flexibility and throughput of automated colony pickers. Not only will automated colony pickers make the entire process quicker (picking up to 3,000 clones per hour), but the results are more consistent and reliable, increasing the quality of the data produced
Speaker	Affiliation	Title
	탁민호 Ph.D. JAPAC BioPharma and Drug Discovery Application Scientist Molecular Devices LLC	The versatility of fully automated bacterial colony picker in synthetic biology
기존 이차원 단층세포 배양 기술은, 실험적 편의성과 값싼 비용이라는 장점을 바탕으로 누구나 쉽게 체외에서 특정세포를 배양할 수 있는 연구플랫폼으로 자리잡았으며, 이렇게 배양된 단층배양세포는 개발중인 신약의 성능과 독성을 평가하기위한 보편적인 in vitro 모델로 널리 사용되어 왔습니다. 그러나, 현저하게 낮은 단층배양 세포의 생체 모사성 때문에 이를 기반으로 도출된 연구결과가 실제 임상에서 재현되지 못하는 사례가 빈번하고, 실제로 전임상 및 임상연구의 높은 실패율을 야기하는 치명적인 한계를 보여주고 있습니다. '미니장기' 라고도 불리는 오가노이드 (organoid)는, 줄기세포로부터 형성된 3차원 세포집합체로, 조직을 구성하는 다양한 세포가 실제 조직의 구조적 특성을 재현하고 있기 때문에 기존 단층배양세포의 한계점을 보완하고 조직내의 생리학적 현상을 모사할 수 있는 새로운 형태의 체외배양 모델입니다. 오가노이드는 이러한 우수한 생체모사성으로 인해 환자 맞춤형 치료제와 재생 치료제 개발과 같은 혁신 바이오 기술의 근간이 될 혁신적인 기술로 평가받고 있습니다. ㈜넥스트앤바이오는 오가노이드 배양기술, High Contents Imaging 등 다양한 첨단 융합기술을 바탕으로 환자맞춤형 정밀의약, 정밀진단키트 개발, 오가노이드기반 당뇨치료제 개발 등 미래지향적 의약학 기술개발을 선도하는 것을 목표로 설립된 회사입니다. 본 발표에서는 ㈜넥스트앤바이오가 연구자들께 제공해 드리고 있는 오가노이드 기반 비임상 연구플랫폼과 그로부터 도출된 연구결과를 소개합니다.
Speaker	Affiliation	Title
	오상택 Ph.D. 수석연구원 Next&Bio	장기 특이적 오가노이드 기반 비임상 연구플랫폼의 활용

PSP01	PCR Chip-adopted Electrochemical Biosensor Module for Diagnosis of Infectious Diseases Won Jae KIM, Jun Yeong JANG, Min Kyung KIM, Jae Hee WON, Chae Min KIM, Minsub CHUNG Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP02	Activated Cell Proliferation by Reactive Oxygen Species Generated from Thimbleful Gold Nanorods Jae Wook LEE¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP03	Biotransformation of Phloretin Using Bacillus subtilis Spore Displayed Tyrosinase Yura JEONG^1,2, Chanjin PARK^1,2, Junehyung KIM^1,2 ¹Department of Chemical Engineering, College of Engineering, Dong-A University, Busan, Korea, ²Center for Sliver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan, Korea
PSP04	Comparison of the Efficiency of Heavy Metal Adsorption on the Cell Surfacedisplayed ECs Ho-Geun JEE, Haewon KIM, Seolhwa LEE, Jong-In WON Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP05	Application of the Porous Ootheca Recombinant Protein by Biomaterials Hye Jin HWANG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Yoo-Jin LEE⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon, Korea, ⁴Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP06	Characterization of Lactobacillus plantarum GNS300 for Various Commercial Applications Jae-Youn JUNG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Young-Keun SONG⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²2Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon,Korea, ⁴4Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP07	Construction of Bi-functional Enzyme of Formate Dehydrogenase and Glycerol Dehydrogenase by Peptide Linker in Methylorubrum extorquens AM1 Seo-young CHOI¹, Hyeonsoo KIM¹, Sukhyeong CHO², Jinwon LEE^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ² Gas Refinery R&D Center, Sogang University, Seoul, Korea
PSP08	Melanin Decolorizing Peroxidase Derived from Bjerkandera adusta Jina BAIK, Taek Jin KANG Department of Chemical Engineering, Dongguk University, Seoul, Korea
PSP09	Cosmetic Effects of Giant Mushroom, Pleurotus nebrodensis Hyo Jung JUNG, Seul Gi KWON, In Hae KIM, Jae hwa LEE Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University, Busan, Korea
PSP10	Metatranscriptome Analysis of Margalefidinium polykrikoides Harmful Algal Bloom Sang-Hyeok CHO^1,2, Yujin JEONG^1,2, Eunju LEE^1,2,Sangrak JIN^1,2, So-Ra KO³,Seung Ho BAEK⁴, Chi-Yong AHN³, Hee-Mock OH³, Byung-Kwan CHO^1,2, Suhyung CHO^1,2 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KI for BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, ⁴Risk Assessment Research Center, Korea Institute of Ocean Science and Technology, Geoje, Korea
PSP11	Assessment of Antibiofilm Potencies of Nervonic and Oleic Acid against Acinetobacter baumannii Using in vitro and Computational Approaches Sagar Kiran KHADKE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP12	Surface Modified PLGA Nanoparticles by Phospholipid for Enhanced Stability and Tissue Penetration Efficiency Doyeon KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, 2Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP13	Improved High-temperature Stability to Solve Cryogenic Transportation and Storage Problems of mRNA Vaccines Minjeong KIM, Taekyoung LEE, Hyunjin KIM, Heejae BANG, Minji KIM, Minsub CHUNG Chemical Engineering, Hongik University, Seoul, Korea
PSP14	Antibiofilm Activity of Saw Palmetto Oil, Lauric Acid, and Myristic Acid on Polymicrobial Biofilms Sang hun KIM, Sun young PARK, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP15	Inhibition of Biofilm Formation and Hyphal Growth of Candida albicans by Mediumchain Fatty Acids Ye Seul KIM, Afreen JAILANI, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP16	Self-assembled Nanocomplex-mediated siRNA Delivery Using Novel Fusion Peptide Yeong Chae RYU¹, Kyung Ah KIM¹, Byoung Choul KIM^1,2, Hui-Min David WANG³, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea, 3Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan
PSP17	Inhibition of Cutibacterium acnes Biofilm Formation by Fatty Acids Including Myristoleic Acid Sun young PARK, Sang hun KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea

PSP18	Diverse Roles of Microbial Indole Derivatives in Eukaryotic Systems Bharath Reddy BOYA, Prasun KUMAR, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP19	Review of pDNA Gene Delivery System Kyoungyeon OH¹, Eunbi LEE¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP20	Inhibition of Biofilm Formation and Virulence of Vibrio parahaemolyticus by Chloroindoles Olajide Sunday FALEYE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP21	shRNA-based Gene Therapy System Using Functional Peptides for the Treatment of Psoriasis Yoo Eun LEE¹, Yeong Chae RYU¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Devision of Bioengineering, Incheon National University, Incheon, Korea
PSP22	Non-invasive Cancer Diagnosis System Using C. elegans-on-a-chip and Odorant Markers Nari JANG¹, Arvie Camille V. DE GUZMAN², Shin sik CHOI^1,2 ¹Department of Food and Nutrition, Myongji University, Yongin, Korea, ²Department of Energy Science and Technology, Myongji University, Yongin, Korea
PSP23	Combination of Chemotherapy and Sonodynamic Therapy with Polylactide-poly (ethylene glycol) Polymersomes for Effective Cancer Treatments Youngheun CHO¹, Taeho KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP24	Antibiofilm and Antivirulence Activities of Fatty Acids Afreen JAILANI, Ye Seul KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP25	Development of Polymersomes Co-deliverying Dual-drug for Overcoming Multidrug Resistance EunKyung HAN¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP26	Designer Lipid Droplet Promotes Production of Value Added Biochemicals by Increasing the Storage Capacity So-Hee SON^1,2, Soo Young MOON³, Yeong-seon JANG¹, Seung Soo OH^2,3, Ju Young LEE¹ ¹Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan, Korea, ²School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, ³Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
PSP27	The Enhanced Production of Succinic Acid Using Engineered Type I Methanotroph Methylomonas sp. DH-1 Jeong-Ho PARK¹, Jae-Hwan JO¹, Min-sik KIM² ¹Gwangju Bio/Energy R&D center, Korea Institute of Energy Research, Gwangju, Korea, ²Energy Resources Upcycling Research Laboratory, Korea Institute of Energy Research, Daejeon, Korea
PSP28	Reconstruction of a Genome-scale Model of Eubacterium limosum Converting C1 Feedstocks to Multi-carbon Products Jiyun BAE, Yoseb SONG, Byung-Kwan CHO Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP29	Effect of Various Structured DNA on the Activity of Terminal Deoxynucleotidyl Transferase Myong Jin LEE, Eui Kyong JANG, Ki Sung PARK, Ki Ha MIN, Sung Ho KIM, Seung Pil PACK Department of Biotechnology and Bioinformatics, Korea University, Sejong, Korea
PSP30	Systematic Analysis on Transcription Unit Architecture of Streptomyces avermitilis Yongjae LEE¹, Namil LEE¹, Soonkyu HWANG¹, Woori KIM¹, Suhyung CHO¹, Bernhard O. PALSSON^2,3,4, Byung-Kwan CHO¹ ¹Department of Biological Sciences and KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ³Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁴Novo Nordisk Foundation Center for Biosustainability, Lyngby, Denmark
PSP31	Construction of the Knock-out Mutant Using a Purified Cas9 Protein in Chlamydomonas reinhardtii Junhwan JANG, Yoongil LEE, EonSeon JIN Department of Life Science, Hanyang University, Seoul, Korea
PSP32	Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome Soonkyu HWANG^1,2, Namil LEE^1,2, Donghui CHOE^1,2, Yongjae LEE^1,2, Woori KIM^1,2, Yujin JEONG^1,2, Suhyung CHO^1,2, Bernhard PALSSON^3,4,5, Byung-Kwan CHO^1,2,6,7 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ⁴Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁵Novo Nordisk Foundation Center for Biosustainability, Kongens Lyngby, Denmark, ⁶Intelligent Synthetic Biology Center, Daejeon, Korea, ⁷Innovative Biomaterials Research Center, KAIST Institutes, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP33	Cloning and Expression of Single-chain Variable Fragment Targeting Epidermal Growth Factor Receptor Seong Yong YOON¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP34	Gene Cloning, Expression, and Characterization of Anti-human Estrogen Receptor Alpha 36 Single Chain Fragment Variable Doo Young LIM¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP35	Cloning and Expression of C6.5 Single-chain Variable Fragment Targeting Human Epidermal Growth Factor Receptor Type2 Hye Min JO, Byeong Hee HWANG Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea

P0001	Magnetic Particle-based Aptamer Selection for the Detection of Various Analytes Myeongjune GO, Seung-Woon JUNG, Seung Min YOO School of Integrative Engineering, Chung-Ang University, Seoul, Korea
P0002	Highly Sensitive Gold Nanourchin for Rapid Bovine Coronavirus Detection Ruth STEPHANIE, Sung Hyun KIM, Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0003	Rosette-shaped Graphitic Carbon Nitride as a Highly Efficient Peroxidase Mimic for Glucose Biosensing Thinh Viet DANG¹, Yun Suk HUH², Moon Il KIM¹ ¹Department of BioNano Technology, Gachon University, Seongnam, Korea, ²Department of Biological Engineering, Inha University, Incheon, Korea
P0004	Continuous Synthesis of DMPC/DHPC Bicelle Using Hydrodynamic Focusing Micro-mixer and Analysis of Its Physicochemical Properties Bong Su KANG¹, Sung Hak CHOI², Kee Sung KIN³, Ho Sup JUNG², Moon Kyu KAWK¹ ¹School of Mechanical Engineering, Kyungpook National University, Daegu, Korea, ²Center for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University, Seoul, Korea, ³Research Inst. of Advanced. Materials, Collage of Engineering, Seoul National University, Seoul, Korea
P0005	Towards Reliable Marine Toxin Detection: Discovering Saxitoxin-specific Bioreceptor via Phage-display Technique So Yeon KWEON, Chan Yeong PARK, Ruth STEPHANIE, Sung Hyun KIM, Yeong Hyeock KIM, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0006	Screening of Aptamers Against Bst Polymerase for Increasing Reverse Transcriptase Activity Do-Young KIM¹, Woo-Ri SHIN¹, Simranjeet Singh SEKHON¹, Sang Yong KIM², Ji-Hyang WEE², Ji-Young AHN¹, Yang-Hoon KIM¹ ¹Major in Microbiology School of Biological Sciences College of Natural Sciences, Chungbuk National University, Cheongju, Korea, ²Department of Food Science and Biotechnology, Shin Ansan University, Ansan, Korea
P0007	Development of Cholesterol Detection Based on the Bienzyme Nanoparticle by Electrochemical Measurement Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0008	Effective Treatment for Cervical Cancer Through Folic Acid Modified Bovine Serum Albumin Nanoparticles Combining Chemo-photodynamic Therapy Suheon KIM¹, Hoomin LEE¹, Shruti SHUKLA², Vivek K. BAJPAI³, Young-Kyu HANC³, Yun Suk HUH¹ ¹Department of Biological Engineering, NanoBio High-Tech Materials Research Center, Inha University, Incheon, Korea, ²Department of Food Science and Technology, National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonipat, Haryana, India, ³Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, Korea
P0009	Co-encapsulation of Multiple Enzymes and Cofactors into Nanoparticles Seoungkyun KIM, Kiyoon KWON, Giyoong TAE, Inchan KWON School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
P0010	Fabrication of Electrochemical Aptasensor that Ag⁺ Ion Intercalated-DNA 3Way Junction on Micro-gap for Interferon Gamma Detection in Human Serum Seungwoo NOH, Taek LEE Department of Chemical Engineering, Kwangwoon University, Seoul, Korea
P0011	Development of Bioelectronic Nose Using Human Olfactory Receptor-embedded Nanodiscs for Diagnosing Gastric Cancer Dongseok MOON, Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea
P0012	Intein Spliced Di-nanoperforator with Higher and Broad-spectrum Anti-influenza Activity Seokoh MOON, Mi Soo KIM, Dae-Hyuk KWEON Department of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Korea
P0013	Fabrication of Electrochemical Biosensor for H1N1 Detection Jeongah PARK Kwangwoon University, Seoul, Korea

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로그인 주의사항
로그인 주의사항 1) 강연물에 대한 온라인 접속 권한은 2023년 4월 12~14일 동안 가능합니다. 2) 등록자에 한해서만 접속이 가능하고 아이디와 비밀번호를 타인과 공유하거나 알려주는 행위 등은 전면 금지됩니다. Q&A 주의 사항 3) 강연에 대한 질문은 ZOOM 채팅창에 이름/소속을 입력 후 작성해주시기 바랍니다. 강연물 저작 재산권법 4) 2023 한국생물공학회 춘계학술발표대회 및 국제심포지엄에 등록된 각종 자료는 저작권법으로 보호됩니다. 따라서 저작권법에 위반하여 각종 자료를 등록자 본인 외 제 3자에게 배포 및 전송, 복사하는 행위는 민·형사상 책임을 질 수 있으니 유의하시기 바랍니다. 위 사항을 모두 확인하셨으면 확인란에 체크해주시기 바랍니다.	확인
개인정보 활용 동의 (필수) 본 홈페이지는 등록자의 개인정보를 아래와 같이 처리함을 알려드립니다. 1. 개인정보의 수집·이용 목적 한국생물공학회에서 수집한 등록자 개인정보는 향후 학회 소식 및 홈페이지 이용권한을 위한 용도로만 활용되고 학회 참가기업의 등록자 정보 데이터를 확인하기 위하여 제공될 수 있습니다. 2. 수집하려는 개인정보의 항목 성명, 이메일, 휴대전화, 직책, 소속기관, 소속명 3. 개인정보의 보유 및 이용 기간 등록된 정보는 본 학회 종료일 이후 1년간 보유하며, 삭제 요청 시 요청자의 개인정보를 재생이 불가능한 방법으로 즉시 파기 합니다. 4. 개인정보의 제3자 제공 수집하는 개인정보를 목적 외의 용도로 이용하거나 제3자에게 제공하지 않습니다. 5. 권리 원칙적으로 개인정보 보호법에 의해 개인정보 수집 동의를 거부할 권리가 있습니다. 다만, 동의가 없을 경우 저작물 접근이 원활하게 진행되지 않을 수 있습니다. 본인은 개인정보보호법에 따라 위 각호 사항을 고지받고 개인정보 활용에 동의합니다.	동의