2023 한국생물공학회 추계학술발표대회 및 국제심포지엄

Special Session for Biotech Companies

Program

Organizers

[S3-1] Special Session for Biotech Companies

Academic and Institute Collaboration Committee

Plenary Lecture Ⅰ
Prof. Shuichi Takayama Georgia Institute of Technology USA H-index=81 Organoid, Cellchip, Organic chemistry Professor, GRA Eminent Scholar Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine	Background Dr. Shu Takayama earned his BS and MS in Agricultural Chemistry at the University of Tokyo. He earned a PhD in Chemistry at The Scripps Research Institute in La Jolla, California studying bio-organic synthesis with Dr. Chi‐Huey Wong. He then worked as a postdoc with Dr. George Whitesides at Harvard University where he focused on applying microfluidics to studying cell and molecular biology. Dr. Takayama began his career at the University of Michigan, where led his lab in the Department of Biomedical Engineering and Macromolecular Science & Engineering for over 17 years. In 2017, the lab moved to Georgia Tech where Shu became the Georgia Research Alliance Price Gilbert Chair Professor of Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering. Dr. Takayama’s research interests are diverse and motivated by clinical and biotechnology needs. He is always interested in hearing from stakeholders in these areas who are seeking engineering collaboration.

Plenary Lecture Ⅰ

Prof. Shuichi Takayama
Georgia Institute of Technology USA
H-index=81 Organoid, Cellchip, Organic chemistry
Professor, GRA Eminent Scholar
Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine

Background

Dr. Shu Takayama earned his BS and MS in Agricultural Chemistry at the University of Tokyo. He earned a PhD in Chemistry at The Scripps Research Institute in La Jolla, California studying bio-organic synthesis with Dr. Chi‐Huey Wong. He then worked as a postdoc with Dr. George Whitesides at Harvard University where he focused on applying microfluidics to studying cell and molecular biology.
Dr. Takayama began his career at the University of Michigan, where led his lab in the Department of Biomedical Engineering and Macromolecular Science & Engineering for over 17 years. In 2017, the lab moved to Georgia Tech where Shu became the Georgia Research Alliance Price Gilbert Chair Professor of Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering.
Dr. Takayama’s research interests are diverse and motivated by clinical and biotechnology needs. He is always interested in hearing from stakeholders in these areas who are seeking engineering collaboration.

Plenary Lecture Ⅱ
Prof. Ashutosh Chilkoti Duke University USA H-index=103 Colorimetric biosensor, Drug Delivery	Background Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University. My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery. Appointments and Affiliations Alan L. Kaganov Distinguished Professor of Biomedical Engineering Professor of Biomedical Engineering Research Professor of Global Health Professor in the Department of Chemistry Core Faculty in Innovation & Entrepreneurship Member of the Duke Cancer Institute Research Interests Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery. Awards, Honors, and Distinctions Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015 Fellow. National Academy of Inventors. 2014 Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013 Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011 Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011 Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010 Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008 Fellow. American Institute for Medical and Biological Engineering. 1996

Plenary Lecture Ⅱ

Prof. Ashutosh Chilkoti
Duke University USA
H-index=103 Colorimetric biosensor, Drug Delivery

Background

Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University.
My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.

Appointments and Affiliations

Alan L. Kaganov Distinguished Professor of Biomedical Engineering
Professor of Biomedical Engineering
Research Professor of Global Health
Professor in the Department of Chemistry
Core Faculty in Innovation & Entrepreneurship
Member of the Duke Cancer Institute

Research Interests

Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery.

Awards, Honors, and Distinctions

Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015
Fellow. National Academy of Inventors. 2014
Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013
Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010
Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008
Fellow. American Institute for Medical and Biological Engineering. 1996

Plenary Lecture Ⅲ
Prof. Jens Nielsen Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden	Background Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering. Presentation Systems Biology of Yeast Metabolism Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅲ

Prof. Jens Nielsen
Department of Biology and Biological Engineering, Chalmers University of Technology,
Gothenburg, Sweden

Background

Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering.

Presentation

Systems Biology of Yeast Metabolism

Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅳ
Prof. Ron Milo Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel	Background Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics: Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals. Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity. Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food. Cell biology & Sustainability by numbers. http://book.bionumbers.org/ Presentation Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂ The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅳ

Prof. Ron Milo
Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel

Background

Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics:
Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals.
Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity.
Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food.
Cell biology & Sustainability by numbers. http://book.bionumbers.org/

Presentation

Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂

The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅴ
Prof. Jay D. KEASLING Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA	Background Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors Presentation Engineered Polyketide Synthases as Platform for Synthetic Chemistry Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅴ

Prof. Jay D. KEASLING
Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA
Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA

Background

Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors

Presentation

Engineered Polyketide Synthases as Platform for Synthetic Chemistry

Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅵ
Prof. Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea	Background Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology. Presentation Bioelectronic Nose for Odor Standardization Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

Plenary Lecture Ⅵ

Prof. Tai Hyun PARK
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea

Background

Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology.

Presentation

Bioelectronic Nose for Odor Standardization

Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

[S2-1] Honorary Lecture by Biotech CEO
CEO JinKoo Hwang LOTTE Chemical Corp., Korea Head of Center Youngheon Choi LOTTE Chemical Corp., Korea	The Growth of LOTTE Chemical and Bio PET Abstract Petrochemical industry is that feedstocks of Naphtha and LPG produce chemical products and specialized solution services to provide raw materials to a wide range of industries including automobiles, fiber, electronics, construction, etc. Petrochemical accounts for a large portion of manufacturing industries, which is ranked 5th in production volume and 3rd in exports volume in manufacturing sector. South Korea is 4th biggest producer of Ethylene, one of the main products in petrochemical industry, globally. Petrochemical industry is a significant part of the industry, but it is pointed out as a major cause of environmental destruction at the same time. There have been concerns and warnings that sustainable growth is becoming more difficult unless the petrochemical industry enhances its own active role in environmental protection and social contribution. LOTTE Chemical has announced “Green Promise 2030”, an eco-friendly strategy, to reinvent itself as a sustainable chemical company along with recent growing interests in ESG management. To achieve the strategy, multifaceted efforts are in full swing. Through 2030 carbon-reduced growth, 2050 carbon neutral (Net-Zero), production 100,000 tons of recycled products, signing up for Global Initiative RE100, and preparation of bio-plastic, LOTTE Chemical aims to diversify portfolios of former general-purpose by expanding our business into specialty products and green future business. Global bio-plastic market including Bio-PET, PBAT, PLA, etc. is expected to grow up to 30 trillion KRW at 15% CAGR in 2025, which double the extent of market over 5 years. In the case of Bio-PET, the market will rise to 15 trillion KRW in 2025, which was 5 trillion KRW in 2020. This growth is being leaded by environmental regulation, demand for eco-friendly/low-carbon products, and customers’ preferences changes. Furthermore, leading retailers are highly encouraged to use bio-based and recycled materials. Since LOTTE Chemical is acutely aware of this demand for the sustainable globe, we are enhancing our capabilities in global bio-plastic market including Bio-PET.

[S2-1] Honorary Lecture by Biotech CEO

CEO JinKoo Hwang
LOTTE Chemical Corp., Korea

Head of Center Youngheon Choi
LOTTE Chemical Corp., Korea

The Growth of LOTTE Chemical and Bio PET

Abstract
Petrochemical industry is that feedstocks of Naphtha and LPG produce chemical products and specialized solution services to provide raw materials to a wide range of industries including automobiles, fiber, electronics, construction, etc. Petrochemical accounts for a large portion of manufacturing industries, which is ranked 5th in production volume and 3rd in exports volume in manufacturing sector. South Korea is 4th biggest producer of Ethylene, one of the main products in petrochemical industry, globally.

Petrochemical industry is a significant part of the industry, but it is pointed out as a major cause of environmental destruction at the same time. There have been concerns and warnings that sustainable growth is becoming more difficult unless the petrochemical industry enhances its own active role in environmental protection and social contribution.

LOTTE Chemical has announced “Green Promise 2030”, an eco-friendly strategy, to reinvent itself as a sustainable chemical company along with recent growing interests in ESG management. To achieve the strategy, multifaceted efforts are in full swing. Through 2030 carbon-reduced growth, 2050 carbon neutral (Net-Zero), production 100,000 tons of recycled products, signing up for Global Initiative RE100, and preparation of bio-plastic, LOTTE Chemical aims to diversify portfolios of former general-purpose by expanding our business into specialty products and green future business.

Global bio-plastic market including Bio-PET, PBAT, PLA, etc. is expected to grow up to 30 trillion KRW at 15% CAGR in 2025, which double the extent of market over 5 years. In the case of Bio-PET, the market will rise to 15 trillion KRW in 2025, which was 5 trillion KRW in 2020. This growth is being leaded by environmental regulation, demand for eco-friendly/low-carbon products, and customers’ preferences changes. Furthermore, leading retailers are highly encouraged to use bio-based and recycled materials. Since LOTTE Chemical is acutely aware of this demand for the sustainable globe, we are enhancing our capabilities in global bio-plastic market including Bio-PET.

[S2-2] Special Lecture Commemorating the Academic Award
Prof. Duk Jae Oh Sejong University, Korea	Enhanced Productivities in Animal Cell Technology : My Experiences Abstract Animal cell technology has been a key platform technology particularly in production of biopharmaceuticals such as therapeutic antibodies, highly glycosylated therapeutic proteins, vaccines and cell/gene therapy products. However, since its industrial applications in early 1980s, the enhancement of the productivity from animal cells has been a strong challenge in animal cell technology due to its lower productivity compared to well-established microbial production system, even though the current productivity of antibodies from recombinant CHO cells reaches higher than 10g/L. Application and progress in the new areas such as ‘cultured meat’ and ‘stem cell technology’ also accelerate the needs for productivity enhancement. In this presentation, the efforts for enhanced productivity from animal cells will be discussed particularly with bioreactor development, cell culture process such as fed-batch and perfusion cultures, cell culture medium development, and cell engineering to establish more productive cell lines. The productivity still matters in animal cell technologies even in the twenty-first century. Keywords productivity, animal cell technology, bioreactor, cell culture process, cell culture medium

[S2-2] Special Lecture Commemorating the Academic Award

Prof. Duk Jae Oh
Sejong University, Korea

Enhanced Productivities in Animal Cell Technology : My Experiences

Abstract
Animal cell technology has been a key platform technology particularly in production of biopharmaceuticals such as therapeutic antibodies, highly glycosylated therapeutic proteins, vaccines and cell/gene therapy products. However, since its industrial applications in early 1980s, the enhancement of the productivity from animal cells has been a strong challenge in animal cell technology due to its lower productivity compared to well-established microbial production system, even though the current productivity of antibodies from recombinant CHO cells reaches higher than 10g/L. Application and progress in the new areas such as ‘cultured meat’ and ‘stem cell technology’ also accelerate the needs for productivity enhancement.
In this presentation, the efforts for enhanced productivity from animal cells will be discussed particularly with bioreactor development, cell culture process such as fed-batch and perfusion cultures, cell culture medium development, and cell engineering to establish more productive cell lines. The productivity still matters in animal cell technologies even in the twenty-first century.

Keywords
productivity, animal cell technology, bioreactor, cell culture process, cell culture medium

기관정보

기관명	한글	싸이티바 코리아	설립일	2019년 7월 1일
기관명	영문	Cytiva Korea	업종	도매 서비스 / 무역, 과학기자재, 진단시약 및 기자재, 오퍼
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		대표전화	02-6201-3800
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		홈페이지	www.cytivalifesciences.co.kr

주요 공적사항

Cytiva는 글로벌 공급자로서, 치료제의 개발 및 제조를 촉진하고 가속화하는 기술과 서비스를 제공하고 있습니다. 과거 GE Healthcare Life Sciences였던 Cytiva는 수십년을 거슬러 올라가는 풍부한 유산을 갖고 2020년부터 Cytiva 로 새롭게 시작했습니다. 우리의 고객은 기초 생물학적 연구에서부터 혁신적인 백신, 항체 및 재조합단백질의 바이오 의약품 및 새로운 세포 및 유전자 치료법 개발에 이르기까지 생명을 구하는 활동을 수행합니다. 우리의 임무는 그들이 더 나은 환경에서 더 빠르고 안전하게 일하는 데 필요한 도구와 서비스를 제공하여 더 나은 환자의 치료 결과를 이끄는 것입니다.
Cytiva는 글로벌 생명과학 리더로서, 삶을 변화시키는 치료법에 접근하여 인류의 건강을 증진시키고자 하는 비전에 전념하고 있습니다. Cytiva는 다양한 규모와 범위의 고객에게 신뢰할 수 있는 파트너로서, 연구 및 제조 워크플로우에 효율성을 제공하여 혁신적인 의약품의 개발과 제조, 그리고 환자에게 이를 전달하는 것을 보장합니다.

Cytiva Korea는 국내 바이오 기업들의 전문 기술력 육성에 대한 고민을 해결하는 데 도움을 주기 위해 <대한민국 바이오의약품 대상> 공모전을 후원하고 있습니다. 바이오의약품 개발 인프라 부족으로 어려움을 겪는 국내기업들을 대상으로 Cytiva의 제품과 패스트트랙센터 (Fast Trak Center)의 기술력을 함께 지원합니다. 배양/정제 공정 스크리닝, 공정 최적화, 공정 스케일업, 비임상시료 생산 등 제품 생산 전반에 걸쳐 제조공정 연구 및 양산에 도움을 드리려고 합니다.

대표기술

기술명	세포 배양 및 단백질 분리 정제를 위한 크로마토그래피 (chromatography) 기술

기술 개요

Cytiva만의 축적된 노하우를 바탕으로 바이오 의약품의 세포 배양/정제 공정 개발 및 스케일업, 분석법 개발, 기술이전, 미국 본사 cGMP 시설과 연계한 임상 시료 및 상업 생산을 지원합니다.
Cytiva의 목표는 특히 FAST TRAK center를 이용하여 고객이 직면한 공정상의 문제들을 해결하도록 도와주고 지원하는 것입니다.

기술 세부 내용

세포 배양의 기술은 싱글유즈 (Single-use) 장비를 이용한 바이오리액터 활용 및 업스트림 공정 개발 전략을 다룹니다. 공정 최적화 및 스케일-업을 위한 중요 변수 전반에 대한 것입니다. ReadyToProcess WAVE는 single-use bag 내부의 용액 움직임에 의한 믹싱 및 기체 전달 기능을 극대화한 single-use rocking bioreactor입니다. 세포 건강에 악영향을 주는 shear stress가 적고 single-use bag 사용으로 교차 오염 위험이 없어 연구 단계나 GMP 초기 종배양에 적합한 기술입니다.
Xcellerex bioreactor는 single-use 전문 브랜드로 바이오 의약품 개발, 생산 및 상용화 방식을 혁신하고 있습니다. 독창적인 바이오의약품 생산 플랫폼을 기반으로 구축된 혁신적인 single-use 어플리케이션 기술을 적용합니다.
단백질 분리 정제 (Protein purification)를 위한 기술과 방법의 개발은 생물공학분야에서 많은 발전을 위한 필수적인 전제조건이 되어져 왔다. 단백질 분리 정제는 간단한 one-step purification 과정에서부터 증명된 대량 정제의 생산 과정에까지 다양하다. 원하는 purity를 얻기 위해서는 종종 한번의 정제 과정 이상이 필요로 되어진다. 성공적인 단백질 정제는 적절한 technique을 선택하고, 그 방법으로 최상의 결과가 나오도록 optimization 하고, 수율 (yield)은 최대로 얻고 요구되는 정제 단계를 최소로 하는 것이다. 대부분의 단백질 정제는 크로마토그래피 (chromatography) 방법을 포함한다. 그 결과로 크로마토그래피는 단백질 정제를 위한 가장 필수적인 기술이다.

기술활용 범위

바이오 공정의 재조합 단백질, 항체, 백신 개발 및 생산을 위한 세포 배양 및 단백질 정제를 위한 분야에 폭넓게 사용되고 있으며, 또한 유전자 및 세로치료제 분야에 있어서도 배양 및 정제 기술을 활용하는 연구 및 생산에 적용되고 있습니다.

[S2-3] 학술대상 수상기념특강
Jeewon LEE Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV	Optimally Fabricated Platforms for Enhanced Cancer Therapy Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

[S2-3] 학술대상 수상기념특강

Jeewon LEE
Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV

Optimally Fabricated Platforms for Enhanced Cancer Therapy

Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

Invited Lecture

Chair

Professor Yong Hwan KIM UNIST, Korea

	The Role and Mission of Sustainable Finance CEO Yunnam ChoDaishin Economic Research Institute, Korea
	16 years of Systems Metabolic Engineering and its Next Journey in Samyang Corporation Head of R&D Center Jin Hwan ParkSamyang Corporation, Korea
	Introduction of BIO-R&D department at Daesang Ingredient BU: A Way Forward to Innovation Principal Research Engineer Doo-jin KANGDaesang Inc., Korea
	Accelerated High-performing Upstream Process of Monoclonal Antibody Lead Scientist Sojeong LEESamsung Biologics, Korea

Recent Trends in the Development of Therapeutic Biologics

Instruction

Designing and engineering new biologics has played essential roles in developing novel therapeutics and expanding the scope of medicine. This session covers representative works of developing next-generation therapeutic biologics against various diseases. The first speaker (Prof. Kim) presents an innovative approach to using endogenous virus-specific CD8+ T cells for cancers based on tumor-specific cytosol-penetrating antibodies. Prof. Jung describes various antibody Fc variants his group has developed so far, which can endow superior functions to antibody therapeutics. Then, Prof. Van Deventer presents a new platform technology to discover crosslinkable antibodies and its application in developing inhibitors against a Botulinum Neurotoxin target. The last speaker (Prof. Lee) presents the analysis results of antibody repertoires to influenza and SARS-CoV-2 and shows how they can be used in engineering antibodies and vaccines.

Professor Tae Hyeon Yoo

Ajou University, Korea

	Keynote Speaker Immunocytokines as Emerging Therapeutics for Cancer Immunotherapy: Focusing on IL-12 Immunocytokine Professor Yong-Sung KimAjou University, Korea
	Invited Speaker Palette of Antibody Fc Variants That Enable Therapeutic Potency Boosting, Effector Function Silencing, or Circulating Half-Life Extension Professor Sang Taek JungKorea University, Korea
	Invited Speaker Covalent Antibody Discovery on the Yeast Surface Against a Botulinum Neurotoxin Target Professor James A. Van DeventerTufts University, USA
	Invited Speaker An Immunoproteomic Survey of the Antibody Landscape: Insights and Opportunities Revealed by Immune Repertoire Profiling Professor Jiwon Lee Dartmouth College,USA

Co-organized by

Synthetic Biology of Secondary Metabolite Producers for Drug Discovery and Development

Instruction

Synthetic biology and metabolic engineering together with related principles and technologies endeavor to redesign and optimize the genetic and regulatory processes of various organisms for our society's sake. In this session, we will discuss recent advances in synthetic biology of secondary metabolite producers with an emphasis on small molecules with human benefits.

Professor Dokyun Na

Chung-Ang University, Korea

	Keynote Speaker Leveraging a Large Actinobacterial Strain Collection for Natural Product Biosynthesis, Engineering, and Drug Discovery Professor Ben ShenUF Scripps Biomedical Research, USA
	Invited Speaker Multi-engineering of microbial cytochrome P450 enzymes Professor Shengying LiShandong University, China
	Invited Speaker Characterization and Engineering of Microbial Small Molecule Biosynthesis for Drug Discovery Professor Yeo Joon YoonSeoul National University, Korea
	Invited Speaker Production of natural sunscreen materials in yeasts Professor Ji-Sook Hahn Seoul National University, Korea
	Invited Speaker Systems Metabolic Engineering for the Enhanced Production of Secondary Metabolites Professor Hyun Uk Kim KAIST, Korea

Antibody Engineering and Cell Culture Engineering

Instruction

The current status of antibody drug research and bioprocess development from top-tier scientists who are most active at the forefront of academia and industry in relation to antibody drug development will be presented. The main topics of discussion are antibody engineering, biologics development, cell culture engineering, and biomanufacturing including media development. It will be an influential forum for leaders and experts from academic and industrial backgrounds to convene and discuss antibody engineering, cell culture engineering, and the related advancements that impact a growing spectrum of modalities including recombinant biologics and downstream processing. Various discussions between academia and industry on related topics will be held.

Professor Soonjo Kwon

Inha University, Korea

Professor Jae Seong Lee

Ajou University, Korea

	Keynote Speaker Demands of secreted protein products - systems biology improve quality and titer of biologics Professor Johan RockbergKTH Royal Institute of Technology, Sweden
	Invited Speaker Real-time monitoring and multi-scale modeling for bioprocess Digital Twin systems toward biomanufacturing 4.0 Professor Dong-Yup LeeSungkyunkwan University, Korea
	Invited Speaker Maximizing performance of your biologics pipeline: Media and process optimization using cutting-edge tools Chief Scientist Yaron SilberbergAjinomoto Genexine, Co., LTD., Korea
	Invited Speaker Stereospecific interactions between histidine and monoclonal antibodies Professor Youngbin Baek Inha University, Korea

Co-organized by

Biosensing Technology & Cell Engineering I

Instruction

This section invites key researchers with expertise in the fields of Biosensing Technology & Cell Engineering. In this symposium, we will discuss Biosensing strategies for developing sensitive biosensors to detect diseases and cell engineering for therapeutics. Speakers present the leading-edge trends and technologies in these fields with a special focus on the applications and developments of biosensor, nanomedicine, stem cell engineering, and tissue engineering. (This symposium is supported by Institute of Integrated Biotechnology and the BK21 Four MCCBE Research Team in Sogang university)

Professor Jeong-Woo Choi

Sogang University, Korea

	Keynote Speaker Innovative Biosensing Technologies to Realize Continuous, Real-time, In Vivo Monitoring Systems Professor Koji SodeUniversity of North Carolina and North Carolina State University, USA
	Keynote Speaker Engineering organoids for regenerative medicine and drug discovery Professor Seungwoo ChoYonsei University, Korea
	Invited Speaker Label-free Detection of Transport Kinetics and Inhibitor Binding of Membrane Transport Proteins with a Two-mode Plasmonic Sensor Professor Ling ChaoNational Taiwan Univeristy, Taiwan
	Invited Speaker Ultrasound Detection of Microcalcification for Early Detection of Breast Cancers and Differential Diagnosis Professor Yangmo Yoo Sogang University, Korea

Biosensing Technology & Cell Engineering II

Professor Taewook Kang

Sogang University, Korea

	Keynote Speaker Biosensor Integrated Internet of Things for Infectious Disease Point of Care Testings Professor Chenzhong Li Tulane University School of Medicine, USA
	Keynote Speaker Cutting-edge technologies for isothermal molecular diagnostics of COVID-19 Professor Hyun Gyu ParkKAIST, Korea
	Invited Speaker Aptameric enzyme subunit for homogeneous detection enabling in situ detection Professor Kazunori IkebukuroTokyo University of Agriculture and Technology, Japan
	Invited Speaker Electrochemical Nanobiosensor for Detection of Viral RNA and Its Mutation Derivative Using Nanoporous Electrode Array (NPEA) Professor Jinho Yoon The Catholic University of Korea, Korea

Co-organized by

Circadian Rhythm and Human Health

Instruction

This special symposium introduces cutting-edge researches focused on the relationship between circadian rhythm and human health. The aim of the special session is to further enhance our understanding of the circadian rhythm topic by inviting 3 prominent speakers who are conducting the state-of-the-art researches on the subject in the United States, Japan, and Korea. Additionally, we will introduce/discuss the research direction of BCA2-RLRC (Biological Clock-based Anti-Aging Convergence Regional Leading Research Center), which was recently launched with the support of the National Research Foundation of Korea.

Professor Seung Pil Pack

Korea University, Korea

Professor Jin Hyub Lee

Korea University, Korea

	Invited Speaker Circadian Rhythm and Human Health: Researches of BCA2-RLRC Professor Seung Pil PackKorea University, Korea
	Keynote Speaker Emerging Links between Circadian Disruption and Cancer Risk Professor Katja A. LamiaScripps Research, USA
	Invited Speaker Towards Systems Biology of Human Sleep/Wake Cycles: Phosphorylation Hypothesis of Sleep Professor Hiroki R. UedaThe University of Tokyo, Japan
	Invited Speaker Suprachiasmatic VIP Neurons Control Circadian Priority of Social Instincts Professor Han Kyoung ChoiDGIST, Korea

Co-organized by

LNP/mRNA Therapeutics

Instruction

The session presents the current research trend on the development of lipid nanoparticle and mRNAs for therapeutic purposes. Professor M.J. Mitchell is an expert on developing novel lipid nanoparticles and applying immunoengineering for the delivery of mRNA therapy. In addition, Professor Hyun Jung Chung from KAIST is also an expert in designing lipid nanoparticles for gene delivery. The last two speakers of the session Professor Kyuri Lee and Professor Jinkuk Kim are experts in RNA therapeutics.

Professor Hyun Jin Kim

Inha University, Korea

Professor Yoosik Kim

KAIST, Korea

	Invited Speaker Lipid Nanoparticles for Overcoming Biological Barriers to Nucleic Acid Delivery Professor Michael J. MitchellUniversity of Pennsylvania, USA
	Invited Speaker Reinforcing Nanoformulations via Chemical Tailoring for in vivo Gene Editing and Delivery Professor Hyun Jung ChungKAIST, Korea
	Invited Speaker Development of RNA structures for cancer immunotherapy Professor Kyuri LeeGyeongsang National University, Korea
	Invited Speaker Antisense oligonucleotide (ASO) as an artificial non-coding RNA to treat diseases Professor Jinkuk KimKAIST, Korea

Co-organized by

BEST-SBJ-KSBB Joint Session I

Instruction

This session presents the joint symposium of Korea-Japan-Taiwan Biotechnology and Bioengineering Societies. A total of eight speakers representing each of the three participating countries will present recent research trends in the community. The presentation will cover a range of topics from traditional microbial engineering to biomedical engineering.

Professor Youngeun Kwon

Dongguk University, Korea

ProfessorYun Jung Heo

Kyung Hee University, Korea

	Invited Speaker Valorization of Spent Mushroom Substrate (SMS) for Circular Bioeconomy Professor Yoong Kit LeongTunghai University, Taiwan
	Invited Speaker Optogenetic approaches for efficient microbial bio-productions Professor Yoshihiro ToyaOsaka University, Japan
	Invited Speaker Development of Tumor Microenvironmental-response Nanoparticles for Effective Cancer Treatment Professor Yun Suk HuhInha University, Korea
	Invited Speaker A New Way of Using Spent Coffee Grounds: Photothermal materials Professor Hsiu-Wen ChienNational Kaohsiung University of Science and Technology, Taiwan

BEST-SBJ-KSBB Joint Session II

Professor Yoosik Kim

KAIST, Korea

ProfessorSeung Pil Pack

Korea University, Korea

	Invited Speaker Artificial lipidation for biomolecular engineering at biointerface Professor Noriho KamiyaKyushu University, Japan
	Invited Speaker Membrane dynamics and its application to biotechnology Professor Masahiro TakagiJapan Advanced Institute of Science and Technology, Japan
	Invited Speaker Cyclic Breathing Lung Inflammation Model for Pulmonary Drug Screening Professor Jen-Huang (Tony) HuangNational Tsing Hua University, Taiwan
	Invited Speaker RNA-based predictive marker for chemotherapy Professor Yoosik KimKorea Advanced Institute of Science and Technology, Korea

Co-organized by

Advanced Micro/Nanofluidic Technology for Biomedical Research

Instruction

This session offers a forum for the exchange of new knowledge on the micro/nanofluidic technologies and bioMEMS with a specific focus on fundamental and translational research in biomedicine. Those technologies in biomedicine has been providing breakthroughs for solving key problems that are considered as critical in biomedicine. In this session, we would like to share the latest trends and advancements in micro/nanofluidic technologies and bioMEMS for biomedicine. (This symposium is hosted by the Institute of Integrated Biotechnology of Sogang University and supported by the BK21 plus program and Sogang-UPenn Convergence Research Center for Theranostics of Emerging Infectious Disease of Sogang University.)

Chair

Professor Taewook KangSogang University, Korea

	Keynote Speaker Microengineered Biomimicry of Human Physiological Systems Professor Dan Dongeun HuhUniversity of Pennsylvania, USA
	Invited Speaker Microfluidic Platforms for Immunotherapy and Genome Editing Professor Aram ChungKorea University, Korea
	Invited Speaker Microscopic DNA Sequence Visualization in a Microfluidic Device Professor Kyubong JoSogang University, Korea
	Invited Speaker Microphysiological Systems for Disease Modeling and Drug Screening Professor Jessie Sungyun Jeon KAIST, Korea

Chair

Professor BongGeun Chung Sogang University, Korea

	Keynote Speaker Reverse Engineering of Tumor Microenvironment Using Microfluidics and 3D Printing Professor Sungsu ParkSungkyunkwan University, Korea
	Keynote Speaker Manufactured Microphysiological System for Modeling Tissue-to-Tissue Barriers: Labscale to Fully Automated System Professor YongTae KimGeorgia Institute of Technology, USA
	Invited Speaker Biomimetic multi-organ-on-a-chip for PK-PD based disease models Professor Jong Hwan SungHongik Unversity, Korea
	Invited Speaker Nematic fibrin fibers enabling vascularized thrombus implants facilitate scarless cutaneous wound healing Professor Joo H. Kang Ulsan National Institute of Science and Technology, Korea

Co-organized by

Sponsored by

Recent Advances of Renewable Environmental Biotechnology for Waste Reuse

Instruction

As the environmental friendly and carbon closed-loop society has been highlighted, the waste material derived recycle and energy production and their implementation and expansion are of great importance recently. Simultaneous organic waste treatement and biogas and resource recovery, have been highlighted as novel concept of waste treatment. In our session, we are going to invite four eminent researchers in this field and discuss the present status and outlook for waste valorization.

Chair

Professor Jung Rae Kim Pusan National University, Korea

	Keynote Speaker Bioelectrochemical Systems for Resource Recovery from Wastewaters Professor Richard Dinsdale University of South Wales, UK
	Invited Speaker Metabolic Regulations and Cellular Functions of Yeast and Their Application to Fermentation and Brewing Professor Hiroshi Takagi Nara Institute of Science and Technology, Japan
	Invited Speaker Integrated Anaerobic Digestion for Biofuel Production and Water Treatment Professor Eunsung Kan Texas A&M University, USA
	Invited Speaker Microbial Electrochemical Process-linked Disinfection for Wastewater Treatment Professor Bongkyu Kim Jeonbuk National University, Korea

From Laboratory to Market: Bioprocess Scale-up

Instruction

Bioprocess development involves understanding the characteristics of reactions at the microbial, bioreactor, and plant levels and optimizing the conditions considering the whole scale of the catalyst-reaction-plant, utilizing a multiscale approach. As evidenced by numerous failure cases, the significance of scaling up in the commercialization of bioprocesses cannot be overemphasized. As the reactor's scale increases, the interactions between cells and their environment become more complicated, leading to significant changes in the overall process, including downstream steps. This session aims to explore various scale-up case studies in industrial bioprocesses and discuss strategies for process development using scale-up data.

Chair

Professor Changman Kim Chonnam National University, Korea

	Keynote Speaker Spatial Metagenomics, Culturomics, and Engineering of Human and Environmental Microbiomes Professor Harris H. Wang Columbia University, USA
	Invited Speaker Accelerating Bioprocess Commercialization at the Advanced Biofuels Process Development Unit (ABPDU) Staff Scientist Eric SundstromLawrence Berkeley National Laboratory, UK
	Invited Speaker Analysis of the Characteristics of the Conventional Microbial Cell Culture Method and Development of New Culture Methods Professor Hideki Aoyagi University of Tsukuba, Japan
	Invited Speaker Integrative Analyses for the Production of Bioplastic Monomer Professor Wangyun Won Korea University, Korea
	Keynote Speaker Hydrogenase and Biohydrogen Production in a Hyperthermophilic Archaeon, Thermococcus Onnurineus NA1 Principal Investigator Sung Gyun Kang Korea Institute of Ocean Science and Technology, Korea

Co-organized by

Trends in Aptamer based Nanobiosystem

Instruction

Aptamer-based nanobiotechnology currently have been providing a critical platform for diagnosis and it will support sustainable bioeconomy in near future. In this session, state of arts aptamer based nanobiostructures will be introduced for futuristic biotechnology.

Chair

Professor Hyun Ho Lee Myongji University, Korea

	Keynote Speaker Therapeutic and Diagnostic Agents Based on Bispecific Aptamers Constructed by Natural DNA Aptamers Identified by MACE®-SELEX Professor Keitaro YoshimotoUniversity of Tokyo, Japan
	Invited Speaker Hotspot-oriented Ligand Display (HOLD) for Peptide-integrated Aptamer Generation in Membrane Receptor Mimicking Professor Seung Soo OhPOSTECH, Korea
	Invited Speaker Aptamers for Enhanced Bacterial Diagnosis, Surveillance, and Control for Environmental Safety Principal Researcher Byoung Chan KimKIST, Korea
	Invited Speaker Recent Development of Rapid Aptasensor for Virus Detection Professor Teak Lee Kwangwoon University, Korea

Co-organized by

Enzyme Engineering for Biofoundry

Instruction

Biofoundry is a key infrastructure that supports biological experiments and manufacturing processes by standardizing, speeding up, and automating design-build-test-learning by combining ICT technologies such as computer-based design, automation, and AI. We will discuss the current trends in enzyme engineering as a key area of white biotechnology that is one of the demand technologies for biofoundry utilization, and also this session will discuss the future development of enzyme engineering in connection with biofoundry facilities in the future.

Chair

Professor Joo-Hyun Seo Kookmin University, Korea
Professor Soo-Jin Yeom Chonnam National University, Korea

	Invited Speaker Machine-learning-assisted Protein Engineering Platform for Desired Evolution Professor Mitsuo UmetsuTohoku University, Japan
	Invited Speaker High-throughput Enzyme Screening Using Genetic Circuit Senior Researcher Kil Koang Kwon Korea Research Institute of Bioscience and Biotechnology, Korea
	Invited Speaker The Catalophore^TM Technology to Search for Function, Not Structures Professor Bettina M. NestlInnophore GmbH, Austria
	Invited Speaker Application of Ancestral Sequence Reconstruction for Clustering and Engineering of Enzymes Professor Jin-Byung ParkEwha Womans University, Korea

Sponsored by

Engineering the Next Generation of Cell-based Therapeutics

Instruction

NK cells and MSCs have emerged as key players in the field of cell-based therapies, offering immense potential for treating a wide range of diseases and disorders. Their unique properties, combined with advances in genetic engineering and bioengineering techniques, have opened up new avenues for therapeutic innovation and personalized medicine. In this session, we will delve into the characteristics and therapeutic potential of NK cells and MSCs. We will explore how researchers are engineering these cells to enhance their efficacy, improve their targeting capabilities, and optimize their interactions with the immune system. By leveraging the innate abilities of NK cells to recognize and eliminate infected or cancerous cells, and the regenerative properties of MSCs to modulate immune responses and promote tissue repair, scientists and engineers are paving the way for transformative treatments.

Chair

Professor Soonjo Kwon Inha University, Korea

	Invited Speaker Stem Cell-based Gene Therapy for Solid Tumors and Chronic Diseases CEO Haeyoung Suh-KimCELLeBRAIN, Ltd., Korea
	Invited Speaker Comparative Analysis of Autologous NK Cell Therapy, Allogeneic NK Cell Therapy, and CAR-NK Cell Therapy: Characteristics and Advantages Development Director Chaok YimTS Bio, Co., Ltd., Korea
	Invited Speaker Biomaterial-mediated Membrane Decoration for Augmenting Immune Synapse Interaction of Natural Killer cells in Cancer Immunotherapy Professor Kyobum KimDongkook University, Korea
	Invited Speaker Nano-PAMP Technologies for Developing Cancer Vaccine and Potent Immune-modulator Professor Sejin SonInha Uniersity, Korea
	Invited Speaker 3D Dermal Papilla-keratinocyte Spheroids at Early Morphogenesis Stage Faculty of Medicine and Health Lifeng KangThe University of Sydney, Australia

Co-organized by

Tissue Engineering & Biomaterial Engineering for Green biotechnology

Instruction

This session aims to introduce various recent and novel tissue engineering and biomaterial strategies to develop new therapeutics, biomaterial scaffolds, and future green technology. Recent research progress on development and application of cell-tissue engineering, biomaterials, biosignaling molecules delivery will be presented in the session.

Chair

Professor Seung-Woo Cho Yonsei University, Korea

Professor Suk Ho Bhang Sungkyunkwan University, Korea

	Keynote Speaker Overview of Generating Genome Edited Animals Professor Goo Jang Seoul National Univeristy, Korea
	Invited Speaker Development of 3D-shaped Cell Delivery Method for Tissue Regeneration Professor Gunjae Jeong The Catholic University of Korea, Korea
	Invited Speaker Understanding the Development Strategy and Regulatory Process of Companion Animal Pharmaceuticals CEO Jaebong MoonDaewoong Pet, Korea
	Invited Speaker Cell-derived Material Engineering for Pharmaceutical and Biomedical Applications Principle Researcher Yoon Ki JoungKorea Institute of Sci. & Tech, Korea
	Invited Speaker Enhancing Skin Wound Repair by Regulating Extracellular Matrix Expression Senior Researcher Sungwon Kim Stanford University, USA

BEST-KSBB Joint Symposium

Instruction

This special international symposium invites outstanding researchers from the KSBB and the BEST to introduce the latest research in bioengineering and promote networking and joint international research between researchers from both organizations.

Chair

Professor Hyung Joon Cha POSTECH, Korea

	Invited Speaker Cofactor Engineering of Pyridoxal 5’-phosphate (PLP) toward High-value Chemicals Production in Genetic Escherichia coli Professor I-Son NgNational Cheng Kung University, Taiwan
	Invited Speaker Towards Continuous Biomanufacturing - Challenges and Current Efforts for the Upstream Processes Professor Jong Youn BaikInha University, Korea
	Invited Speaker Unveiling the Photothermal Applications of Spent Coffee Grounds: A Promising Resource Professor Hsiu-Wen ChienNational Kaohsiung University of Science and Technology, Taiwan
	Invited Speaker Oxygen Delivering Nanosomes for the Treatment of Cancer Professor Jonghoon ChoiChung-Ang University, Korea
	Invited Speaker Advancing Drug Development: Recapitulating Tumor Microenvironments using Microfluidics Professor Jen-Huang HuangNational Tsing Hua University, Taiwan

Biotechnology for Sustainable Environment

Instruction

This session will explore the expansive potential of biotechnology, focusing on its role in the design and alteration of cellular systems. We will discuss how these advances enable the production of valuable compounds and offer solutions to environmental challenges. Our intent is to inspire attendees with the promising roles of biotechnology and its applications in creating a more sustainable future.

Chair

Professor Jay Keasling UC-Berkeley, USA
Professor Sung Kuk Lee UNIST, Korea

	Keynote Speaker Enhanced Production of Docosahexaenoic Acid (DHA) and Squalene in Unicellular Marine Thraustochytrid Protists Professor Guangyi Wang Tianjin University, China
	Invited Speaker Sustainable Production of Non-natural Acetins from Microbial Fermentation Professor Seon Won KimGyeongsang National University, Korea
	Invited Speaker Applications of Synthetic Biology in Non-model Microorganisms Senior Engineer Howard ChouShenzhen Institute of Advanced Technology, CAS, China
	Invited Speaker Permeability Engineered Next Generation Droplet for High Throughput Single Cell Analysis Young Principal Investigator Jingwei ZhangFudan University, China
	Invited Speaker Cupriavidus cauae PHS1: A Promising Thermotolerant Microrganism for Biorefinery Professor Sung Kuk Lee UNIST, Korea

Co-organized by

Crafting Sustainable Meats: Advances in Food Biotechnology

Instruction

As concerns over the future of our planet and food security intensify, we recognize the crucial role sustainable meat production can play in addressing these issues. This session aims to spotlight the efforts of researchers striving to solve these challenges and discuss how ground-breaking advancements in bioengineering can enable us to produce meat in a more sustainable and environmentally friendly manner. Participating in this session presents a fantastic opportunity to hear from leading researchers in the field, gain fresh insights, and exchange ideas. It is open to food scientists, bioengineers, policymakers, and anyone interested in the subject matter. We eagerly anticipate your active participation as we navigate towards the future of sustainable food production.

Chair

Director Daehee Lee KRIBB, Korea
Professor Soo-Jung Kim Chonnam National University, Korea

	Keynote Speaker A Single-cell Derived Food Ingredients for Protein Transformations Professor Pil KimThe Catholic University of Korea, Korea
	Invited Speaker Microbial Production of Heme and Zinc Protoporphyrin IX for the Sustainable Consumption of Meat Professor Kyeong Rok ChoiKAIST, Korea
	Invited Speaker Current Status of Global Cultured Meat Development and Sharing of Seaweed Crop. Cases CTO Heejae LeeSeawith, Korea
	Invited Speaker Application of Biotechnology and Bioengineering for Cell-cultured Food CTO Heejung KimCellMEAT, Korea

Metabolic Engineering in the Era of Biotechnology

Instruction

Metabolic engineering with help of systems biology and synthetic biology has created a new paradigm to engineer microorganisms for efficient production of desired bio-products. In this symposium, we will discuss recent progress in the development of such platform technologies for building microbial cell factories based on diverse microorganisms.

Chair

Professor Sang Woo Seo Seoul National University, Korea

	Keynote Speaker The Rapid Optimization of Biosynthetic Enzymes on the Terpenoid Synthetic Pathway Employing Cell-free Protein Synthesis Professor Hyungdon YunKonkuk University, Korea
	Keynote Speaker Characterization and Engineering of the Biosynthetic Gene Cluster for Antitumor Angucycline Kidamycin from Streptomyces sp. W2061 Principal Researcher Young-Soo HongKRIBB, Korea
	Invited Speaker Sustainable Production of PHAs from Carbon Dioxide Using Engineered Cupriavidus Necator H16 Senior Researcher Ja Kyong KoKIST, Korea
	Invited Speaker Characterization of Natural Products Biosynthesis for Drug Discovery Professor Yeon Hee BanKangwon National University, Korea

Co-organized by

Young Scientist Forum I

Instruction

This Young Scientist Forum will cover the state-of-the-art technologies in (1) AI/Machine learning-based biomedical engineering and (2) the development of various bioactive materials for novel drug dedlivery platforms. Four young scienctists/engieeres will discuss (a) aging-related phenotypic markers via machine learning models, (b) AI technologies in colloidal applications, (c) Peptide-meidated mRNA delivery, and (d) immunotherapeutic approaches using nitric oxide.

Chair

Professor Kyobum Kim Dongguk University, Korea

	인사말 이상엽 회장한국생물공학회
	Define and Estimate Healthy Aging by Establishing Phenotypic Biomarkers and Machine Learning Models Invited Speaker Professor Yongmin ChoMyongji University, Korea
	Artificial Intelligence-Assisted Colloid Platform for Biomedical Applications Invited Speaker Professor Sangsik KimKyungpook National University, Korea
	Self-Adjusting Coiled Coil Peptide Building Block for Stable mRNA Carrier Invited Speaker Senior Researcher Jun Shik ChoiKorea Institute of Radiological & Medical Sciences, Korea
	A Journey Toward Nitric Oxide Immunotherapeutics Invited Speaker Professor Jihoon KimYonsei University, Korea

Young Scientist Forum II

Instruction

This Young Scientist Forum highlights current developments in (1) cuttind-edge engineering techniques for immune celll therapy products and (2) cell modulation for a series of versitle engineering applications. Five presenters will introduce (a) synthetic circuit desing in immne cell engineering, (b) synthetic biology-meidated CAR-T cell engineeeing, (c) enzyme engineering, (d) microbial engineering for drug discovery, and (e) wastewater treatment using microalgae.

Chair

Professor Jung Rae Kim Pusan National University, Korea

	Clinically-driven Design of Synthetic Circuits for Engineering Therapeutic Immune Cells Invited Speaker Professor Hui-Shan LiKAIST, Korea
	Synthetic Biology Meets CAR-T Cell Therapy Invited Speaker Professor Jang Hwan ChoSeoul National University, Korea
	Harnessing the Power of Evolution: Innovations in Biocomposites and Enzyme Activity Engineering Invited Speaker Senior Researcher Myung Hyun NohKRICT, Korea
	Elucidation of the Biosynthetic Pathways of Microbial Natural Products for Drug Discovery Invited Speaker Professor Yeon Hee BanKangwon National University, Korea
	Changes in Microbial Population during Piggery Wastewater Treatment Process using Microalgae Invited Speaker Professor Minsik KimInha University, Korea

Special Session of CJ CheilJedang

Instruction

CJ BIO provides the world-class eco-friendly BIO technologies with high quality products and solutions through its global bases. CJ BIO division oversees the Animal Nutrition & Health business using exceptional fermentation and refinement technologies. By strengthening its technological capabilities and improving cost competitiveness in productivity, CJ BIO has achieved a dominant position in the global feed amino acid market. The success of CJ BIO was achieved based on the Core Technologies possessed by the Institute of BIO Technology, and we would like to introduce this Core Technologies in this session.

Chair

Research Planning Pro Youngwoong Lee CJ CHEILJEDANG, Korea

	Bioprocess Modeling Applicable Manufacturing Group Manager Chanhun ParkCJ CHEILJEDANG, Korea
	Scale-up Strategy and Case Studies of the Bio-based Fermentation Process Project Leader Sangmin ParkCJ CHEILJEDANG, Korea
	Multi-Omics Technologies, Platformization, and Applications Group Manager Sunggun LeeCJ CHEILJEDANG, Korea
	Process Design of Enzymatic PET Depolymerization Principal Research Engineer Insung Lee CJ CHEILJEDANG, Korea

Co-organized by

Prospects for Industrialization of Active Phamaceutical Ingredient(API) using SFC

Instruction

The establishment of a supercritical fluid utilization industrial cluster aims to utilize the supercritical state of carbon dioxide for applications in the pharmaceutical industry. This cluster plans to develop and produce innovative technologies and products in various fields such as bio-based materials and pharmaceutical production, using supercritical fluids. Supercritical fluids offer various advantages, including extraction and purification of bio-based materials. Through collaboration among research institutions, businesses, and the government, efforts will be made to promote infrastructure development, technology advancement, and workforce training to foster sustainable regional economic growth and innovation. It is believed that this will contribute to nurturing a competitive supercritical fluid industry domestically and internationally, while forming new industrial clusters.

Chair

Director Yong Joo Kim NanoBio Research Center, Korea

	Invited Speaker Establishment of Industrial Clusters Utilizing Supercritical Fluid Technology Director Yong Joo KimNanoBio Research Center, Korea
	Invited Speaker Application of Supercritical Fluid Chromatography to the Pharmaceutical Industry Executive Director Kyung Hyun GahmVerdant Technology Inc., Korea
	Invited Speaker Discovery of a New NASH Clinical Candidate and Chiral Separation Using SFC Professor Jin Hee AhnGIST, Korea
	Invited Speaker The Development and Applications of Chiral HPLC Columns Professor Wonjae Lee Chosun University, Korea

Co-organized by
NanoBio Research Center

Future of Industrial Biotechnology

Instruction

This session was designed to explore thefuture of industrial (white) biotechnology, where experts will delve into its transformative potential. We will discuss how this field is revolutionizing industries by making processes more sustainable and efficient. Sessions will cover topics such as sustainable feedstock sourcing, the role of biofoundaries in research and development, insights from polymer engineers on materials and sustainability, and industry perspectives on integrating biotechnological processes. Gain valuable knowledge and be inspired by the possibilities of white biotechnology as we shape a greener and more innovative future together.

Chair

Professor Sunghoon Park UNIST, Korea

	Invited Speaker Macroalgae Biorefinery: New Opportunity for Industrial Biotechnology Professor Gyoo Yeol JungPOSTECH, Korea
	Invited Speaker How to utilize unusual carbon sources (C1 gases and lignin)? Professor Yong Hwan KimUNIST, Korea
	Invited Speaker Public Biofoundries: A Catalyst for Synthetic Biology Innovation Director Seung-Goo LEEKRIBB, Korea
	Invited Speaker Future of White Bio Industry from a Polymer Perspective Research Fellow Jonggeon JegalKorea Research Institute of Chemical Technology, Korea
	Invited Speaker Approach for White Bio Commercialization Assistant Vice President Hyohak SongGS Caltex, Korea

Co-organized by

Sponsored by

GC Biopharma's Platform Technology and Science for Drug Development

Instruction

GC Biopharma has been leading the pharmaceutical industry in Korea with development of innovative drugs and biologics based on the stable business foundation of vaccines, plasma derivatives, and biologics accumulated over half a century. Recently, GC Biopharma has expanded new modality platforms to develop innovative biologics and has been constructing development platforms to discovery, process and analysis. They are highly scalable as they can be applied to various disease areas and can generate a large number of candidates, enabling effective and efficient development of innovative biologics. In this session, we will introduce GC Biopharma's development platforms of antibody therapeutics and mRNA vaccines.

Chair

Team lead Dong-sik Kim GC Biopharma, Korea

Invited Speaker

Introduction of GCBP Biofoundry Platform

Team lead Dong-sik KimGC Biopharma, Korea

Invited Speaker

Development of mRNA Manufacturing Platform for Vaccines and Therapeutics

Project lead Byunghoon Jung GC Biopharma, Korea

Invited Speaker

Analytical Method Development for mRNA Vaccine

Team lead Jiyoun KimGC Biopharma, Korea

Co-organized by

[한국산업기술기획평가원 성과발표회 I] 3D 생체조직칩기반신약개발 플랫폼구축사업 성과발표회

Instruction

ㅇ (기술교류) 수행기관 간 과제별 R&D 추진현황에 대한 기술교류
ㅇ (실무협의) 3D생체조직칩기반신약개발 플랫폼구축사업 현안사항 및 향후계획 논의

3D생체조직칩기반신약개발 플랫폼구축사업 과제별 성과발표

사업 과제별 성과활용 계획 및 진행현황 소개

현안사항 및 향후계획 논의

[한국산업기술기획평가원 성과발표회 II] 바이오위해평가 원팀 리노베이션 사업 성과발표회

Instruction

ㅇ (연구개발 동향) 산업용 유전자변형생물체(LMO) 관련 연구개발 동향 안내
ㅇ (기술교류) 과제 연구개발 내용 및 진행현황 공유
ㅇ (실무협의) 바이오위해평가원팀리노베이션사업 현안사항 및 향후계획 논의

바이오위해평가 원팀 리노베이션 사업 과제별 성과발표

사업 과제별 성과활용 계획 및 진행현황 소개

현안사항 및 향후계획 논의

[한국산업기술기획평가원 성과발표회 III] 바이오매스기반탄소중립형바이오플라스틱제품기술개발사업 성과발표회

Instruction

ㅇ (기술교류) 수행기관 간 과제별 R&D 추진현황에 대한 기술교류
ㅇ (실무협의) 바이오매스기반탄소중립형바이오플라스틱제품기술개발사업 현안사항 및 향후계획 논의

바이오매스기반탄소중립형바이오플라스틱제품기술개발사업 과제별 성과발표

사업 과제별 차년도 계획 및 진행현황 소개

현안사항 및 향후계획 논의

[한국산업기술기획평가원 성과발표회 IV] 개량의약품 협력 협의체 기술교류회

Instruction

ㅇ (기술교류) 협의체 참여기관 간 과제별 R&D 추진현황에 대한 기술교류
ㅇ (운영방안 논의) 개량의약품 R&D 협의체 연차별 운영방안 논의

개량의약품 분야 과제별 R&D 성과발표

개량의약품 분야 과제별 R&D 차년도 계획 및 진행현황 소개

협의체 연차별 운영 계획 안내 및 의견 청취

Co-organized by

The Future of Cosmetics: Transformative Innovations through Biotechnology

Instruction

Biotechnology has been widely used in the cosmetics industry to develop materials for antioxidant, anti-aging, anti-inflammatory, and melanin synthesis inhibition purposes. In this symposium, we will explore the biotechnological techniques used to develop the materials necessary for the future cosmetics industry. We aim to introduce the latest research progress on new sunblock materials, anti-inflammatory materials, environmentally friendly microbead materials, biocompatible materials, and customized cosmetic materials.

Chair

Professor Sang Hyun Lee Konkuk University, Korea

	Invited Speaker Increased Water Resistance and Skin Adhesion through the Hybrid of Fatty Acid Ester and Titanium Dioxide Senior Researcher Yongwoo KimKOLMAR ,Korea
	Invited Speaker Finding the Solution Key for Intractable Chronic Skin Diseases from Natural Products Professor Hyung Seo HwangSemyung University, Korea
	Invited Speaker Nanopolysaccharides for Cosmetics Professor Dong Soo HwangPOSTECH, Korea
	Invited Speaker Biocompatible Mateirlas for Cosmetic Applications Professor Hyemin KimKonkuk University, Korea
	Invited Speaker Development and Application of Customized Cosmetics Using Jeju Bioresources Chief Researcher In Soo SuhJeju Technopark, Korea

Co-organized by

Nanomaterial-based Theragnostics for Brain Disorders

Instruction

Nanotheragnostic technologies have accelerated diagnostic and therapeutic decision-making and enhanced the quality of life for patients. Theragnostic nanomaterials added the potential for diagnosing and treating various human disorders effectively and precisely. Our studies found that the multiple forms of nanomaterials enable continuous diagnosis and immediate treatment of diseases, offering significant advancements in theragnostic development. This section demonstrates the effectiveness of nanomaterials and nanoelectronics for brain disorders through studies conducted on rodents and monkeys.

Chair

Professor Sunggu Yang Incheon National University, Korea

	Invited Speaker Multiscale Decoding and Encoding of Auditory Perception Professor Sungchil YangCity University of Hong Kong, Hong Kong
	Invited Speaker Biodegradable Melanin-like Electroactive Materials for Bioelectronics Professor Bong Sup ShimInha University, Korea
	Invited Speaker Nonhuman Primate Neuroscience Research: Recent Advances Dr. Youngjeon LeeKorea Research Institute of Bioscience & Biotechnology, Korea
	Invited Speaker A Wireless Edge Computing BBCI Platform for Free-moving Study Dr. Sung Q LeeElectronics and Telecommunications Research Institute, Korea

런천세미나 I - 바이오 소부장 연대협력 협의체 우수 연구성과 발표 세미나

인사말씀
이은규 명예교수
한양대학교

바이오의약품 생산용 배지 첨가물 개발
박정수 상무
주식회사 팬젠

알콜계 표면살균제의 개발경과 및 시사점
박성삼 소장
덕산약품공업(주)

장비 수요-공급 연대협력 성과(바이오의약품 생산용 세포배양장비 개발)
이인수 이사
㈜씨엔에스

산업부 R&D 사업 주요사항 안내

바이오 소부장 R&D 종합토론

Co-organized by

Sponsored by

[S7-2] 국가연구안전관리본부 세미나

October 6, 2023, 11:50-13:00 (Room 101-102)

시험 ‧ 연구용 유전자변형생물체 안전관리 제도 및 규제동향
박수종 팀장
한국생명공학연구원 국가연구안전관리본부

Co-organized by

PSP01	PCR Chip-adopted Electrochemical Biosensor Module for Diagnosis of Infectious Diseases Won Jae KIM, Jun Yeong JANG, Min Kyung KIM, Jae Hee WON, Chae Min KIM, Minsub CHUNG Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP02	Activated Cell Proliferation by Reactive Oxygen Species Generated from Thimbleful Gold Nanorods Jae Wook LEE¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP03	Biotransformation of Phloretin Using Bacillus subtilis Spore Displayed Tyrosinase Yura JEONG^1,2, Chanjin PARK^1,2, Junehyung KIM^1,2 ¹Department of Chemical Engineering, College of Engineering, Dong-A University, Busan, Korea, ²Center for Sliver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan, Korea
PSP04	Comparison of the Efficiency of Heavy Metal Adsorption on the Cell Surfacedisplayed ECs Ho-Geun JEE, Haewon KIM, Seolhwa LEE, Jong-In WON Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP05	Application of the Porous Ootheca Recombinant Protein by Biomaterials Hye Jin HWANG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Yoo-Jin LEE⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon, Korea, ⁴Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP06	Characterization of Lactobacillus plantarum GNS300 for Various Commercial Applications Jae-Youn JUNG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Young-Keun SONG⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²2Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon,Korea, ⁴4Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP07	Construction of Bi-functional Enzyme of Formate Dehydrogenase and Glycerol Dehydrogenase by Peptide Linker in Methylorubrum extorquens AM1 Seo-young CHOI¹, Hyeonsoo KIM¹, Sukhyeong CHO², Jinwon LEE^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ² Gas Refinery R&D Center, Sogang University, Seoul, Korea
PSP08	Melanin Decolorizing Peroxidase Derived from Bjerkandera adusta Jina BAIK, Taek Jin KANG Department of Chemical Engineering, Dongguk University, Seoul, Korea
PSP09	Cosmetic Effects of Giant Mushroom, Pleurotus nebrodensis Hyo Jung JUNG, Seul Gi KWON, In Hae KIM, Jae hwa LEE Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University, Busan, Korea
PSP10	Metatranscriptome Analysis of Margalefidinium polykrikoides Harmful Algal Bloom Sang-Hyeok CHO^1,2, Yujin JEONG^1,2, Eunju LEE^1,2,Sangrak JIN^1,2, So-Ra KO³,Seung Ho BAEK⁴, Chi-Yong AHN³, Hee-Mock OH³, Byung-Kwan CHO^1,2, Suhyung CHO^1,2 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KI for BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, ⁴Risk Assessment Research Center, Korea Institute of Ocean Science and Technology, Geoje, Korea
PSP11	Assessment of Antibiofilm Potencies of Nervonic and Oleic Acid against Acinetobacter baumannii Using in vitro and Computational Approaches Sagar Kiran KHADKE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP12	Surface Modified PLGA Nanoparticles by Phospholipid for Enhanced Stability and Tissue Penetration Efficiency Doyeon KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, 2Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP13	Improved High-temperature Stability to Solve Cryogenic Transportation and Storage Problems of mRNA Vaccines Minjeong KIM, Taekyoung LEE, Hyunjin KIM, Heejae BANG, Minji KIM, Minsub CHUNG Chemical Engineering, Hongik University, Seoul, Korea
PSP14	Antibiofilm Activity of Saw Palmetto Oil, Lauric Acid, and Myristic Acid on Polymicrobial Biofilms Sang hun KIM, Sun young PARK, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP15	Inhibition of Biofilm Formation and Hyphal Growth of Candida albicans by Mediumchain Fatty Acids Ye Seul KIM, Afreen JAILANI, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP16	Self-assembled Nanocomplex-mediated siRNA Delivery Using Novel Fusion Peptide Yeong Chae RYU¹, Kyung Ah KIM¹, Byoung Choul KIM^1,2, Hui-Min David WANG³, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea, 3Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan
PSP17	Inhibition of Cutibacterium acnes Biofilm Formation by Fatty Acids Including Myristoleic Acid Sun young PARK, Sang hun KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea

PSP18	Diverse Roles of Microbial Indole Derivatives in Eukaryotic Systems Bharath Reddy BOYA, Prasun KUMAR, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP19	Review of pDNA Gene Delivery System Kyoungyeon OH¹, Eunbi LEE¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP20	Inhibition of Biofilm Formation and Virulence of Vibrio parahaemolyticus by Chloroindoles Olajide Sunday FALEYE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP21	shRNA-based Gene Therapy System Using Functional Peptides for the Treatment of Psoriasis Yoo Eun LEE¹, Yeong Chae RYU¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Devision of Bioengineering, Incheon National University, Incheon, Korea
PSP22	Non-invasive Cancer Diagnosis System Using C. elegans-on-a-chip and Odorant Markers Nari JANG¹, Arvie Camille V. DE GUZMAN², Shin sik CHOI^1,2 ¹Department of Food and Nutrition, Myongji University, Yongin, Korea, ²Department of Energy Science and Technology, Myongji University, Yongin, Korea
PSP23	Combination of Chemotherapy and Sonodynamic Therapy with Polylactide-poly (ethylene glycol) Polymersomes for Effective Cancer Treatments Youngheun CHO¹, Taeho KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP24	Antibiofilm and Antivirulence Activities of Fatty Acids Afreen JAILANI, Ye Seul KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP25	Development of Polymersomes Co-deliverying Dual-drug for Overcoming Multidrug Resistance EunKyung HAN¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP26	Designer Lipid Droplet Promotes Production of Value Added Biochemicals by Increasing the Storage Capacity So-Hee SON^1,2, Soo Young MOON³, Yeong-seon JANG¹, Seung Soo OH^2,3, Ju Young LEE¹ ¹Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan, Korea, ²School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, ³Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
PSP27	The Enhanced Production of Succinic Acid Using Engineered Type I Methanotroph Methylomonas sp. DH-1 Jeong-Ho PARK¹, Jae-Hwan JO¹, Min-sik KIM² ¹Gwangju Bio/Energy R&D center, Korea Institute of Energy Research, Gwangju, Korea, ²Energy Resources Upcycling Research Laboratory, Korea Institute of Energy Research, Daejeon, Korea
PSP28	Reconstruction of a Genome-scale Model of Eubacterium limosum Converting C1 Feedstocks to Multi-carbon Products Jiyun BAE, Yoseb SONG, Byung-Kwan CHO Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP29	Effect of Various Structured DNA on the Activity of Terminal Deoxynucleotidyl Transferase Myong Jin LEE, Eui Kyong JANG, Ki Sung PARK, Ki Ha MIN, Sung Ho KIM, Seung Pil PACK Department of Biotechnology and Bioinformatics, Korea University, Sejong, Korea
PSP30	Systematic Analysis on Transcription Unit Architecture of Streptomyces avermitilis Yongjae LEE¹, Namil LEE¹, Soonkyu HWANG¹, Woori KIM¹, Suhyung CHO¹, Bernhard O. PALSSON^2,3,4, Byung-Kwan CHO¹ ¹Department of Biological Sciences and KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ³Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁴Novo Nordisk Foundation Center for Biosustainability, Lyngby, Denmark
PSP31	Construction of the Knock-out Mutant Using a Purified Cas9 Protein in Chlamydomonas reinhardtii Junhwan JANG, Yoongil LEE, EonSeon JIN Department of Life Science, Hanyang University, Seoul, Korea
PSP32	Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome Soonkyu HWANG^1,2, Namil LEE^1,2, Donghui CHOE^1,2, Yongjae LEE^1,2, Woori KIM^1,2, Yujin JEONG^1,2, Suhyung CHO^1,2, Bernhard PALSSON^3,4,5, Byung-Kwan CHO^1,2,6,7 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ⁴Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁵Novo Nordisk Foundation Center for Biosustainability, Kongens Lyngby, Denmark, ⁶Intelligent Synthetic Biology Center, Daejeon, Korea, ⁷Innovative Biomaterials Research Center, KAIST Institutes, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP33	Cloning and Expression of Single-chain Variable Fragment Targeting Epidermal Growth Factor Receptor Seong Yong YOON¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP34	Gene Cloning, Expression, and Characterization of Anti-human Estrogen Receptor Alpha 36 Single Chain Fragment Variable Doo Young LIM¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP35	Cloning and Expression of C6.5 Single-chain Variable Fragment Targeting Human Epidermal Growth Factor Receptor Type2 Hye Min JO, Byeong Hee HWANG Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea

P0001	Magnetic Particle-based Aptamer Selection for the Detection of Various Analytes Myeongjune GO, Seung-Woon JUNG, Seung Min YOO School of Integrative Engineering, Chung-Ang University, Seoul, Korea
P0002	Highly Sensitive Gold Nanourchin for Rapid Bovine Coronavirus Detection Ruth STEPHANIE, Sung Hyun KIM, Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0003	Rosette-shaped Graphitic Carbon Nitride as a Highly Efficient Peroxidase Mimic for Glucose Biosensing Thinh Viet DANG¹, Yun Suk HUH², Moon Il KIM¹ ¹Department of BioNano Technology, Gachon University, Seongnam, Korea, ²Department of Biological Engineering, Inha University, Incheon, Korea
P0004	Continuous Synthesis of DMPC/DHPC Bicelle Using Hydrodynamic Focusing Micro-mixer and Analysis of Its Physicochemical Properties Bong Su KANG¹, Sung Hak CHOI², Kee Sung KIN³, Ho Sup JUNG², Moon Kyu KAWK¹ ¹School of Mechanical Engineering, Kyungpook National University, Daegu, Korea, ²Center for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University, Seoul, Korea, ³Research Inst. of Advanced. Materials, Collage of Engineering, Seoul National University, Seoul, Korea
P0005	Towards Reliable Marine Toxin Detection: Discovering Saxitoxin-specific Bioreceptor via Phage-display Technique So Yeon KWEON, Chan Yeong PARK, Ruth STEPHANIE, Sung Hyun KIM, Yeong Hyeock KIM, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0006	Screening of Aptamers Against Bst Polymerase for Increasing Reverse Transcriptase Activity Do-Young KIM¹, Woo-Ri SHIN¹, Simranjeet Singh SEKHON¹, Sang Yong KIM², Ji-Hyang WEE², Ji-Young AHN¹, Yang-Hoon KIM¹ ¹Major in Microbiology School of Biological Sciences College of Natural Sciences, Chungbuk National University, Cheongju, Korea, ²Department of Food Science and Biotechnology, Shin Ansan University, Ansan, Korea
P0007	Development of Cholesterol Detection Based on the Bienzyme Nanoparticle by Electrochemical Measurement Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0008	Effective Treatment for Cervical Cancer Through Folic Acid Modified Bovine Serum Albumin Nanoparticles Combining Chemo-photodynamic Therapy Suheon KIM¹, Hoomin LEE¹, Shruti SHUKLA², Vivek K. BAJPAI³, Young-Kyu HANC³, Yun Suk HUH¹ ¹Department of Biological Engineering, NanoBio High-Tech Materials Research Center, Inha University, Incheon, Korea, ²Department of Food Science and Technology, National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonipat, Haryana, India, ³Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, Korea
P0009	Co-encapsulation of Multiple Enzymes and Cofactors into Nanoparticles Seoungkyun KIM, Kiyoon KWON, Giyoong TAE, Inchan KWON School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
P0010	Fabrication of Electrochemical Aptasensor that Ag⁺ Ion Intercalated-DNA 3Way Junction on Micro-gap for Interferon Gamma Detection in Human Serum Seungwoo NOH, Taek LEE Department of Chemical Engineering, Kwangwoon University, Seoul, Korea
P0011	Development of Bioelectronic Nose Using Human Olfactory Receptor-embedded Nanodiscs for Diagnosing Gastric Cancer Dongseok MOON, Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea
P0012	Intein Spliced Di-nanoperforator with Higher and Broad-spectrum Anti-influenza Activity Seokoh MOON, Mi Soo KIM, Dae-Hyuk KWEON Department of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Korea
P0013	Fabrication of Electrochemical Biosensor for H1N1 Detection Jeongah PARK Kwangwoon University, Seoul, Korea

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로그인 주의사항
로그인 주의사항 1) 강연물에 대한 온라인 접속 권한은 2023년 10월 4~6일 동안 가능합니다. 2) 등록자에 한해서만 접속이 가능하고 아이디와 비밀번호를 타인과 공유하거나 알려주는 행위 등은 전면 금지됩니다. Q&A 주의 사항 3) 강연에 대한 질문은 ZOOM 채팅창에 이름/소속을 입력 후 작성해주시기 바랍니다. 강연물 저작 재산권법 4) 2023 한국생물공학회 추계학술발표대회 및 국제심포지엄에 등록된 각종 자료는 저작권법으로 보호됩니다. 따라서 저작권법에 위반하여 각종 자료를 등록자 본인 외 제 3자에게 배포 및 전송, 복사하는 행위는 민·형사상 책임을 질 수 있으니 유의하시기 바랍니다. 위 사항을 모두 확인하셨으면 확인란에 체크해주시기 바랍니다.	확인
개인정보 활용 동의 (필수) 본 홈페이지는 등록자의 개인정보를 아래와 같이 처리함을 알려드립니다. 1. 개인정보의 수집·이용 목적 한국생물공학회에서 수집한 등록자 개인정보는 향후 학회 소식 및 홈페이지 이용권한을 위한 용도로만 활용되고 학회 참가기업의 등록자 정보 데이터를 확인하기 위하여 제공될 수 있습니다. 2. 수집하려는 개인정보의 항목 성명, 이메일, 휴대전화, 직책, 소속기관, 소속명 3. 개인정보의 보유 및 이용 기간 등록된 정보는 본 학회 종료일 이후 1년간 보유하며, 삭제 요청 시 요청자의 개인정보를 재생이 불가능한 방법으로 즉시 파기 합니다. 4. 개인정보의 제3자 제공 수집하는 개인정보를 목적 외의 용도로 이용하거나 제3자에게 제공하지 않습니다. 5. 권리 원칙적으로 개인정보 보호법에 의해 개인정보 수집 동의를 거부할 권리가 있습니다. 다만, 동의가 없을 경우 저작물 접근이 원활하게 진행되지 않을 수 있습니다. 본인은 개인정보보호법에 따라 위 각호 사항을 고지받고 개인정보 활용에 동의합니다.	동의