2021 한국생물공학회 추계학술발표대회 및 국제심포지엄

2021 Plenary Lecturers

Program

Plenary Lecturers

Plenary Lecture Ⅰ

Prof. James J. Collins
Plenary Lecture Ⅱ

Prof. David Baker
Plenary Lecture Ⅲ

Prof. Jens Nielsen
Plenary Lecture Ⅳ

Prof. Ron Milo
Plenary Lecture Ⅴ

Prof. Jay D. KEASLING
Plenary Lecture Ⅵ

Prof. Tai Hyun PARK

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Plenary Lecture Ⅰ
Prof. James J. Collins Institute for Medical Engineering & Science and Department of Biological Engineering, Massachusetts Institute of Technology, Broad Institute of MIT and Harvard, Wyss Institute, Harvard University, Massachusetts, USA	Background Jim Collins is the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT, as well as a Member of the Harvard-MIT Health Sciences & Technology Faculty. He is also a Core Founding Faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University, and an Institute Member of the Broad Institute of MIT and Harvard. He is one of the founders of the field of synthetic biology, and his research group is currently focused on using synthetic biology to create next-generation diagnostics and therapeutics. Professor Collins' patented technologies have been licensed by over 25 biotech, pharma and medical devices companies, and he has co-founded a number of companies, including Synlogic, Senti Biosciences, Sherlock Biosciences and Cellarity, as well as Phare Bio, a non-profit focused on AI-driven antibiotic discovery. He has received numerous awards and honors, including a Rhodes Scholarship and a MacArthur "Genius" Award, and he is an elected member of all three national academies - the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine. Presentation Synthetic Biology: Life Redesigned Synthetic biology is bringing together engineers, physicists and biologists to model, design and construct biological circuits out of proteins, genes and other bits of DNA, and to use these circuits to rewire and reprogram organisms. These re-engineered organisms are going to change our lives in the coming years, leading to cheaper drugs, rapid diagnostic tests, and synthetic probiotics to treat infections and a range of complex diseases. In this talk, we highlight recent efforts to create synthetic gene networks and programmable cells, and discuss a variety of synthetic biology applications in biotechnology and biomedicine.

Plenary Lecture Ⅰ

Prof. James J. Collins
Institute for Medical Engineering & Science and Department of Biological Engineering,
Massachusetts Institute of Technology, Broad Institute of MIT and Harvard, Wyss Institute, Harvard
University, Massachusetts, USA

Background

Jim Collins is the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT, as well as a Member of the Harvard-MIT Health Sciences & Technology Faculty. He is also a Core Founding Faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University, and an Institute Member of the Broad Institute of MIT and Harvard. He is one of the founders of the field of synthetic biology, and his research group is currently focused on using synthetic biology to create next-generation diagnostics and therapeutics. Professor Collins' patented technologies have been licensed by over 25 biotech, pharma and medical devices companies, and he has co-founded a number of companies, including Synlogic, Senti Biosciences, Sherlock Biosciences and Cellarity, as well as Phare Bio, a non-profit focused on AI-driven antibiotic discovery. He has received numerous awards and honors, including a Rhodes Scholarship and a MacArthur "Genius" Award, and he is an elected member of all three national academies - the National Academy of Sciences, the National Academy of Engineering, and the National Academy of Medicine.

Presentation

Synthetic Biology: Life Redesigned

Synthetic biology is bringing together engineers, physicists and biologists to model, design and construct biological circuits out of proteins, genes and other bits of DNA, and to use these circuits to rewire and reprogram organisms. These re-engineered organisms are going to change our lives in the coming years, leading to cheaper drugs, rapid diagnostic tests, and synthetic probiotics to treat infections and a range of complex diseases. In this talk, we highlight recent efforts to create synthetic gene networks and programmable cells, and discuss a variety of synthetic biology applications in biotechnology and biomedicine.

Plenary Lecture Ⅱ
Prof. David Baker Department of Biochemistry, University of Washington, Seattle, USA	Background David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, the Henrietta and Aubrey Davis Endowed Professor in Biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. His research group is focused on the design of macromolecular structures and functions. He received his Ph.D. in biochemistry with Randy Schekman at the University of California, Berkeley, and did postdoctoral work in biophysics with David Agard at UCSF. Dr. Baker has received awards from the National Science Foundation, the Beckman Foundation, and the Packard Foundation. He is the recipient of the Breakthrough Prize in Life Sciences, Irving Sigal and Hans Neurath awards from the Protein Society, the Overton Prize from the ISCB, the Feynman Prize from the Foresight Institute, the AAAS Newcomb Cleveland Prize, the Sackler prize in biophysics, and the Centenary Award from the Biochemical society. Sixty-five of his mentees have gone on to independent faculty positions, he has published over 500 research papers, been granted over 100 patents, and co-founded 11 companies. Dr. Baker is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. He is also a project leader with The Audacious Project. Presentation The Coming of Age of De Novo Protein Design Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. Our goal is to design a new generation of proteins that address current-day problems not faced during evolution. In contrast to traditional protein engineering efforts, which have focused on modifying naturally occurring proteins, we design new proteins from scratch based on Anfinsen’s principle that proteins fold to their global free energy minimum. We compute amino acid sequences predicted to fold into proteins with new structures and functions, produce synthetic genes encoding these sequences, and characterize them experimentally. SARS-CoV-2 provided a test of the relevance of these methods to real-world challenges. In this talk, I will describe the de novo design of SARS-CoV-2 candidate diagnostics, therapeutics, and vaccines: designed switches that luminesce in the presence of antiviral antibodies, designed 55 residue proteins that bind to the viral Spike with picomolar affinity and block infection, and nanoparticle immunogens which elicit much higher yields of neutralizing antibodies in animals than the Spike trimer that is the basis of most current vaccine trials. I will close by describing the status of getting these into the clinic, and lessons for combatting future pandemics."

Plenary Lecture Ⅱ

Prof. David Baker
Department of Biochemistry, University of Washington, Seattle, USA

Background

David Baker is the director of the Institute for Protein Design, a Howard Hughes Medical Institute Investigator, the Henrietta and Aubrey Davis Endowed Professor in Biochemistry, and an adjunct professor of genome sciences, bioengineering, chemical engineering, computer science, and physics at the University of Washington. His research group is focused on the design of macromolecular structures and functions.
He received his Ph.D. in biochemistry with Randy Schekman at the University of California, Berkeley, and did postdoctoral work in biophysics with David Agard at UCSF.
Dr. Baker has received awards from the National Science Foundation, the Beckman Foundation, and the Packard Foundation. He is the recipient of the Breakthrough Prize in Life Sciences, Irving Sigal and Hans Neurath awards from the Protein Society, the Overton Prize from the ISCB, the Feynman Prize from the Foresight Institute, the AAAS Newcomb Cleveland Prize, the Sackler prize in biophysics, and the Centenary Award from the Biochemical society. Sixty-five of his mentees have gone on to independent faculty positions, he has published over 500 research papers, been granted over 100 patents, and co-founded 11 companies.
Dr. Baker is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. He is also a project leader with The Audacious Project.

Presentation

The Coming of Age of De Novo Protein Design

Proteins mediate the critical processes of life and beautifully solve the challenges faced during the evolution of modern organisms. Our goal is to design a new generation of proteins that address current-day problems not faced during evolution. In contrast to traditional protein engineering efforts, which have focused on modifying naturally occurring proteins, we design new proteins from scratch based on Anfinsen’s principle that proteins fold to their global free energy minimum. We compute amino acid sequences predicted to fold into proteins with new structures and functions, produce synthetic genes encoding these sequences, and characterize them experimentally. SARS-CoV-2 provided a test of the relevance of these methods to real-world challenges. In this talk, I will describe the de novo design of SARS-CoV-2 candidate diagnostics, therapeutics, and vaccines: designed switches that luminesce in the presence of antiviral antibodies, designed 55 residue proteins that bind to the viral Spike with picomolar affinity and block infection, and nanoparticle immunogens which elicit much higher yields of neutralizing antibodies in animals than the Spike trimer that is the basis of most current vaccine trials. I will close by describing the status of getting these into the clinic, and lessons for combatting future pandemics."

Plenary Lecture Ⅲ
Prof. Jens Nielsen Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden	Background Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering. Presentation Systems Biology of Yeast Metabolism Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅲ

Prof. Jens Nielsen
Department of Biology and Biological Engineering, Chalmers University of Technology,
Gothenburg, Sweden

Background

Jens Nielsen has a PhD degree (1989) from DTU and was appointed full Professor there in 1998. In 2008 he was recruited as Professor to Chalmers, Sweden, and in 2019 as CEO of the BioInnovation Institute, Denmark. Jens Nielsen has published 800+ papers that have been cited >85,000 times and his current H-index is 132. Jens Nielsen has supervised more than 100 PhD students and more than 75 post doctoral researchers. He is inventor of 50+ patents and founder of several biotech companies. He has received numerous awards, including the Nature Mentor, ENI Award and the Eric and Sheila Samson Primeministers Prize for Transportation Fuels, and he is member of the several academies including National Academy of Sciences and National Academy of Engineering in the USA, Royal Swedish Academy of Sciences, Royal Danish Academy of Science and Letters, Royal Swedish Academy of Engineering Sciences and Chinese Academy of Engineering.

Presentation

Systems Biology of Yeast Metabolism

Metabolic Engineering relies on a thorough understanding of how the many different metabolic reactions in the cell to be engineered interacts. Genome-scale metabolic models offers a very strong tool for performing quantitative analysis of how the many different reactions in the metabolic network interacts, and through the addition of kinetic and proteome constraints to these models their predictive strength has significantly improved. However, these models can also be used for integrative analysis of quantitative data, e.g. proteomics and metabolomics data. In the lecture there will be presented progress on how kinetic and proteome constraints can improve the predictive strength of genome-scale metabolic models for use in metabolic engineering. Examples will be given of both identification of novel metabolic engineering designs and of using these models for gaining novel insight into the functioning of metabolism.

Plenary Lecture Ⅳ
Prof. Ron Milo Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel	Background Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics: Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals. Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity. Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food. Cell biology & Sustainability by numbers. http://book.bionumbers.org/ Presentation Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂ The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅳ

Prof. Ron Milo
Department. of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel

Background

Ron Milo is a professor at the Weizmann Institute of science in Israel. With his lab members he brings the tools of systems biology to bear on the challenges of sustainability. His research aims to understand the cellular highways of energy and carbon transformations in quantitative terms both within living cells and in the global environment. He is passionate about better understanding the world with the aid of numbers and is the author of “Cell biology by the numbers”, translated to six languages. His lab focuses on the following research topics:
Enhancing carbon fixation. Combining synthetic biology with metabolic modeling we design and implement novel carbon fixation pathways in E. coli, that can convert atmospheric CO₂ into food, fuels and fine chemicals.
Quantifying the anthropocene. Performance of a global census of the biosphere biomass with a focus on wild-mammals, arthropods and plants, enabling us to portray the effects of humanity.
Environmental potential of dietary choices. Compute the environmental burdens associated with animal- and plant-based items, giving a rigorous approach to minimizing the ecological footprint associated with our food.
Cell biology & Sustainability by numbers. http://book.bionumbers.org/

Presentation

Conversion of Escherichia coli to Generate All Biomass Carbon from CO₂

The living world is largely divided into autotrophs that convert CO₂ into biomass and heterotrophs that consume organic compounds. In spite of wide-spread interest in renewable energy storage and more sustainable food production, the engineering of industrially relevant heterotrophic model organisms to use CO₂ as their sole carbon source has so far remained an outstanding challenge. I will describe the achievement of this transformation on laboratory timescales with the help of rational design making use of constraint-based modeling. We constructed and evolved Escherichia coli to produce all its biomass carbon from CO₂. Reducing power and energy, but not carbon, are supplied via the one-carbon molecule formate, which can be produced electrochemically. Rubisco and phosphoribulokinase were co-expressed with formate dehydrogenase to enable CO₂ fixation and reduction via the Calvin-Benson-Bassham cycle. Autotrophic growth was achieved following several months of continuous laboratory evolution in a chemostat under intensifying organic carbon limitation and confirmed via isotopic labeling.

Plenary Lecture Ⅴ
Prof. Jay D. KEASLING Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA	Background Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors Presentation Engineered Polyketide Synthases as Platform for Synthetic Chemistry Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅴ

Prof. Jay D. KEASLING
Department of Bioengineering and Chemical and Biomolecular Engineering, University of California, Berkeley, USA
Biological Systems & Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, USA

Background

Jay D. KEASLING is the Philomathia Professor of Alternative Energy at the University of California, Berkeley in the Departments of Bioengineering and Chemical and Biomolecular Engineering, senior faculty scientist at Lawrence Berkeley National Laboratory, and Chief Executive Officer of the Joint BioEnergy Institute (JBEI). Dr. Keasling’s research focuses on the metabolic engineering of microorganisms for degradation of environmental contaminants or for environmentally friendly synthesis of drugs, chemicals, and fuels. Keasling received a B.S. in Chemistry and Biology from the University of Nebraska and M.S. and Ph.D. in Chemical Engineering from the University of Michigan, and did post-doctoral research in biochemistry at Stanford University. He is a member of the National Academy of Engineering and the National Academy of Inventors

Presentation

Engineered Polyketide Synthases as Platform for Synthetic Chemistry

Polyketides are one of the largest classes of natural products, possessing immense structural diversity and complex chemical architectures. Many polyketides (PKs) are among the most important secondary metabolites for their applications in medicine, agriculture, and industry. Examples include anticancer drugs (epothilone), antibiotics (erythromycin), insecticides (spinosyn A) and antifungals (amphotericin B). These particular examples of polyketides are biosynthesized by multimodular enzyme complexes known as type I modular polyketide synthases (PKSs). Working in an assembly-line fashion, multimodular PKSs assemble and tailor readily available acylCoAs within the host cell into large, complex, chiral molecules. Each of these PKSs comprises a series of modules that can be further dissected into a series of domains responsible for the extension of the polyketide back- bone through condensation and selective reductive processing of an acyl-CoA building block. The collinear architecture of these modules, apparent by inspection of the domains present and the predictive selectivity motifs harbored within, provide insights into the chemical connectivity and stereochemical configuration of the polyketide metabolite from analysis of its coding sequence. While PKSs have been traditionally studied for the production of pharmaceuticals, engineered modular PKSs have the potential to be an extraordinarily effective retrosynthesis platform for the bio-production of products from biofuels and commodity chemicals to both pharmaceutical and nonpharmaceutical fine and specialty chemicals. By rearranging existing polyketide modules and domains, one can exquisitely control chemical structure from DNA sequence alone. However, this potential has only just begun to be realized as the compounds that have been made using engineered PKSs represent a small fraction of the potentially accessible chemical space. In my talk, I will highlight work from our laboratory where we have engineered PKSs to produce a variety of commodity and specialty chemicals and developed software and high throughput robotic platforms to enable design and construction of PKSs in high throughput.

Plenary Lecture Ⅵ
Prof. Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea	Background Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology. Presentation Bioelectronic Nose for Odor Standardization Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

Plenary Lecture Ⅵ

Prof. Tai Hyun PARK
School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea

Background

Tai Hyun PARK is Professor at the School of Chemical and Biological Engineering, Seoul National University, and also Director of BK 21 FOUR Project. He received his B.S. degree (Seoul National University), M.S. degree (KAIST), and Ph.D. degree (Purdue University) all in Chemical Engineering, and was a postdoctoral fellow at the University of California at Irvine. He is a member of The Korean Academy of Science and Technology (KAST) and also a member of The National Academy of Engineering of Korea (NAEK). He is a Fellow of the University of Tokyo. He is serving as Editor of “Biotechnology Journal (Wiley)” and “Enzyme and Microbial Technology (Elsevier)”. He served as Appointed Director of National Research Council of Science & Technology. He was President of The Korean Society for Biotechnology and Bioengineering (KSBB), President of Advanced Institutes of Convergence Technology (AICT), President of Bio-MAX Institute, and President of KOFAC (Korea Foundation for the Advancement of Science and Creativity). His research area is bioelectronic nose and tongue, cellular engineering, and nanobiotechnology.

Presentation

Bioelectronic Nose for Odor Standardization

Communication about odors among persons is very difficult because their perceptions are not exactly same and their vocabularies for odors are different. These make us more difficult to classify and standardize odors. More than one hudred years ago, Alexander Graham Bell, who invented the telephone, said that we have very many different kinds of smells, but until you can measure their likenesses and differences you can have no science of odor. However, it is still difficult to measure odors. Why is it so difficult? Because we have not understood the identity of 'odor' until Robert Axel and Linda Buck discover the mechanism of smell sensing on the molecular basis. Now we know that information of an odor is the combinatorial pattern made of the olfactory receptors activated by the odor molecules. A bioelectronic nose using human olfactory receptors mimics human olfactory system and can make the combinatorial pattern of the activated olfactory receptors as in human nose. In this sense, a bioelectronic nose will play an important and useful role as a tool for odor standardization. In this presentation, I will discuss the principles and methods for the development of bioelectronic nose and its application for odor standardization.

[S2-1] 기업 CEO 초청 특별강연
Jin-Ho Seo CV Research Institute of Food and Biotechnology, The SPC group, Korea	Are Fermented Foods Art or Technology? Humans have enjoyed fermented foods for thousands of years mainly because of improved nutritional values, unique flavors and texture and excellent health benefits. Most of fermented foods are produced by natural or spontaneous fermentation processes, which is a technical barrier for large-scale production. In order to change the production system of fermented foods from experience-based to principle-based, one of the key factors is to develop a fermentation starter, which performs the desired fermentation process. This talk will present the challenges and opportunities for development of fermentation starters for the food industry. The SPC Research Institute of Food and Biotechnology (SPC-RIFB) successfully developed superior fermentation starters for baking and patented in the U.S., China, France and Japan. The first generation of a fermentation starter based on a baker’s yeast Saccharomyces cerevisiae (SPC SNU 70-1) was developed in 2015 by using evolution engineering of a natural yeast strain isolated from Nuruk, a traditional microbial source in Korea. The second generation of a fermentation starter (SPC sourdough) composed of one S. cerevisiae strain and four lactic acid bacteria was developed in 2019 based on the symbiosis principle of natural ecosystems. These two starters were applied to more than 200 bread products to generate annual revenue of about 1x1012 KRW. More research efforts will be focused on development of next generation of fermentation starters in an attempt to pave the technology highway for globalization of “K-bread”. Keywords fermentation starter, sourdough,yeast,lactic acid bacteria

[S2-1] 기업 CEO 초청 특별강연

Jin-Ho Seo CV
Research Institute of Food and Biotechnology, The SPC group, Korea

Are Fermented Foods Art or Technology?

Humans have enjoyed fermented foods for thousands of years mainly because of improved nutritional values, unique flavors and texture and excellent health benefits. Most of fermented foods are produced by natural or spontaneous fermentation processes, which is a technical barrier for large-scale production. In order to change the production system of fermented foods from experience-based to principle-based, one of the key factors is to develop a fermentation starter, which performs the desired fermentation process.
This talk will present the challenges and opportunities for development of fermentation starters for the food industry. The SPC Research Institute of Food and Biotechnology (SPC-RIFB) successfully developed superior fermentation starters for baking and patented in the U.S., China, France and Japan. The first generation of a fermentation starter based on a baker’s yeast Saccharomyces cerevisiae (SPC SNU 70-1) was developed in 2015 by using evolution engineering of a natural yeast strain isolated from Nuruk, a traditional microbial source in Korea. The second generation of a fermentation starter (SPC sourdough) composed of one S. cerevisiae strain and four lactic acid bacteria was developed in 2019 based on the symbiosis principle of natural ecosystems. These two starters were applied to more than 200 bread products to generate annual revenue of about 1x1012 KRW. More research efforts will be focused on development of next generation of fermentation starters in an attempt to pave the technology highway for globalization of “K-bread”.

Keywords
fermentation starter, sourdough,yeast,lactic acid bacteria

기관정보

기관명	한글	아미코젠 주식회사	설립일	2000.05.29
기관명	영문	Amicogen Inc.	업종	그 외 기타 식료품 제조업
기관주소	경남 진주시 진성면 동부로 1259번길 64		대표전화	055-759-6161
기관주소	경남 진주시 진성면 동부로 1259번길 64		홈페이지	http://www.amicogen.com/

회사 소개

당사는 지역대학의 교수(현 신용철 대표이사)와 대학(원) 졸업생들이 2000년 5월 29일 유전자 진화기술(Molecular gene evolution)을 핵심기술로 하여 창업한 바이오벤처 기업으로서, 2013 코스닥 시장 기술 상장 이후 현재 182명의 인력이 ‘특수효소’, ‘헬스케어’, ‘단백질 정제용 레진 사업에 집중하여 지역경제와 국가 산업발전에 이바지하고 있는 회사임. 독자적인 유전자진화기술 및 특수효소 원천기술에 대해 한국거래소 기술성 평가 독립적인 2개의 전문 평가기관으로부터 A 등급을 획득하여 기술 성장 기업으로 인정받았음.
당사의 유전자진화기술은 대사공학 (Metabolic engineering)과 더불어 산업바이오 (Industrial biotechnology 혹은 White biotechnology)를 가능하게 하는 독자적 핵심기술로서 21세기 인류가 당면한 환경오염, 기후변화, 에너지 및 자원고갈 등의 문제를 바이오 기술로 해결하고기존 기업의 지속가능성을 높이는 혁신적인 바이오기술임. 대한민국 대표 산업바이오 기업으로서 “세계적인 바이오 제품을 개발하여 인류건강과 환경보호에 공헌이라는 가치를 실현” 이라는 기업 미션을 가지고 있음.
※ 바이오산업은 의약바이오(Red biotechnology), 농업바이오(Green biotechnology), 산업바이오(White biotechnology)로 나누어지며, 이 중에서 산업바이오는 가장 최근에 생겨난 바이오산업의 ‘제 3의 물결’로 일컬어지는 분야임 (White Biotechnology, Frost & Sullivan Ltd., 2011) 즉, 원료물질을 미생물이나 효소를 이용하여 산업적으로 유용한 물질로 전환시키는 바이오텍 기술임
당사는 상장 이후 기술과 사업에 시너지를 낼 수 있는 국내외 산학연 기술을 도입함은 물론, 기업의 지속가능성을 위해 혁신적 기술력을 보유한 국내외 우수기업에 투자를 진행해 왔음(현재 11개의 종속사, 관계사를 보유). 이러한 전략적 투자를 통하여 기존 사업의 시너지를 확대하고, 사업영역을 확장해왔음.

기업 연혁

2000.05. 아미코젠 주식회사 설립(자본금 55백만원)
2002.06. Inno-Biz 기업 인증
2004.05. 다국적 제약사에 항생제 원료 생산용 특수효소(CA효소) 기술이전(약 100억원 규모)
2004.08. 건강기능식품전문제조업 허가(식품의약품안전처)
2006.01. GMP 적용업소 지정(식품의약품안전처 2006-03호)
2006.10. 벤처기업대상 대통령표창 수상(산업자원부)
2009.05. 대일수출 유망 100대 기업 선정(KOTRA, 지식경제부)
2011.12. 세계일류상품 선정(N-아세틸글루코사민)-지식경제부
2013.07. 경상남도 고용우수기업 인증 ◦2013.09. 한국거래소 코스닥상장
2013.12. 수출 1천만불탑 수상
2014.07. ㈜셀리드 투자, Shandong Amicogen Biotechnology 설립
2015.04. 매일경제 글로벌리더 기업(헬스케어부문) 선정
2015. ㈜스킨메드, ㈜아미코젠퍼시픽, 아미코젠(중국)바이오팜유한회사 등 M&A
2016.10. 한국경제매거진 베스트브랜드대상(헬스케어부문)선정
2017.08. 스웨덴 관계사 Bio-Works Technologies사 IPO 성공(Nasdaq Firstnorth)
2019.02. 관계사 ㈜셀리드 코스닥시장 상장
2019.04. 글로벌강소기업 지정
2019.04. 피니톨(Pinitol), 간 건강 기능성 개별인정형 원료 승인(식약처)
2019.12. 중국 청도시 콜라겐펩타이드 공장 완공(중국 유통사 캉마이천社와의 JV)
2019.12. 우수기업연구소 지정(과학기술정보통신부)
2020.04. 문산 제3공장 비거트 공장 증설
2020.05. Artiabio사와 배지 기술 도입 JV계약 체결
2020.09. 머니투데이 첨단 바이오 소재 부문 최우수 IR기업 선정
2020.11. Lysando사와 엔돌라이신 기술 도입 계약 체결
2020.12. 바이오분야 우수기업 표창 수상(산업통상자원부)

핵심보유기술 및 기술경쟁력

특수효소 사업 - 유전자 진화기술 : 자연에서 일어나는 돌연변이 현상을 연구실의 시험관 내에서 인위적으로 가속화시켜 단기간 내 우리가 원하는 성질을 갖는 유전자를 선발하는 기술로서 특수효소개발에 이용됨 - 효소반응기술 : 고정화 효소를 이용하여 기질 투입과 반응산물의 회수를 연속적이고 용이하게 할 수 있는 반응기술 개발. 기질의 용해성 및 농도, 고정화효소 투입, 반응 온도 등의 사항들을 조절하여 공정을 최적화함으로써 생산 수율 및 품질을 증대시킴 - 바이오디젤 생산효소 : 당사가 개발한 고정화 효소인 CalB-10X는 친환경적으로 바이오디젤을 생산할 수 있는 효소공정으로 생산되며 향후 미래의 석유고갈문제를 해결할 것으로 기대됨
바이오 의약 소재 사업 - 글로벌 바이오의약품 시장규모는 2017년 2,706억달러(약 306조원)에서 연평균 8.6%로 성장하여 2023년 4,420억달러(약 500조원) 규모로 확대될 전망이며, 기존 블록버스터 의약품의 특허만료와 더불어 혁신신약 개발이 둔화됨에 따라 글로벌 제약기업들의 바이오의약품 시장에 대한 관심이 높아지고 바이오 의약소재 사업이 활발하게 진행되고 있음. 당사는 당사의 효소기술을 확장하여 바이오의약품 생산에 필수적으로 사용되는 “친화성 레진”사업을 추진하고 있으며, 당사의 유전자 진화기술은 단백질의 특성을 개량하는 기술로서 효소, 호르몬 단백질, 바이오의약단백질, 펩타이드 등 다양한 단백질 및 펩타이드 제품의 개발에 응용될 수 있는 장점을 이용하여 항체 단백질 분리에 필수적인 Protein A, G, L, A/G 레진을 비롯하여 바이오의약회사에서 사용되는 "알칼리내성의 Protein A 레진" 개발을 완료하였음.
헬스케어 사업 - 콜라겐트리펩타이드 CTP : 분자량이 30만 Da이상인 콜라겐의 인체 흡수율을 높이기 위해 당사에서는 당사에서 개발한 BP효소를 이용하여 분자량이 약 500 Da인 콜라겐트리펩타이드로 분해하였으며, 이 중에서도 피부 재생에 활용도가 높은 GPH (Gly-Pro-Hyp)의 함량이 타 콜라겐 제품에 비해 높기 때문에 높은 시장 경쟁력을 가짐. 현재 준비 중인 개별인정형을 취득하면 시장점유율을 더 높일 수 있을 것으로 기대하고 있음 - D-카이로-이노시톨(DCI)/피니톨(PI) : 혈당조절과 여성호르몬 조절 등 다양한 생리기능을 가진 건강기능성 식품 원료이며, 특히 당사의 DCI는 효소분해로 생산된 친환경 기능성 소재라는 원료의 차별성과 안전성으로 유럽을 중심으로 수요와 매출이 점점 높아지고 있음. 피니톨의 경우에는 간 건강과 관련하여 2019년 5월 식품의약품안전처로부터 개별인정형 소재로 인정받음 - 곡물발효효소 : 유럽시장에 새로이 선보인 곡물발효효소(식물성효소)는 서양의 유산균과 비교되는 동양 고유의 건강식품으로써, 유럽과 미국 등 건강식품 원조 국가들의 관심이 높아 아시아 시장으로 매출이 한정되어 있던 곡물발효효소의 신규 시장 개척 가능성이 높음. 또한, 곡물발효효소에 관한 기능성 및 메커니즘 연구가 세계적으로 많이 진행되고 있지 않은 관계로 효소식품시장을 선점할 수 있음 - N-아세틸글루코사민(NAG) : 자사 특수효소 중 하나인 Chimax-N(Fungal Endo- and Exo- chitinases)을 이용한 효소반응기술로 천연소재인 게 껍질의 키틴을 단량체인 N-아세틸글루코사민(NAG)으로 분해함으로 생산된 건강기능식품 고시형 원료임 (관절 및 피부건강에 도움을 줄 수 있음)

기관정보

기관명	한글	싸이티바 코리아	설립일	2019년 7월 1일
기관명	영문	Cytiva Korea	업종	도매 서비스 / 무역, 과학기자재, 진단시약 및 기자재, 오퍼
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		대표전화	02-6201-3800
기관주소	인천광역시 연수구 송도미래로 9 BRC 연구소 2동 202호		홈페이지	www.cytivalifesciences.co.kr

주요 공적사항

Cytiva는 글로벌 공급자로서, 치료제의 개발 및 제조를 촉진하고 가속화하는 기술과 서비스를 제공하고 있습니다. 과거 GE Healthcare Life Sciences였던 Cytiva는 수십년을 거슬러 올라가는 풍부한 유산을 갖고 2020년부터 Cytiva 로 새롭게 시작했습니다. 우리의 고객은 기초 생물학적 연구에서부터 혁신적인 백신, 항체 및 재조합단백질의 바이오 의약품 및 새로운 세포 및 유전자 치료법 개발에 이르기까지 생명을 구하는 활동을 수행합니다. 우리의 임무는 그들이 더 나은 환경에서 더 빠르고 안전하게 일하는 데 필요한 도구와 서비스를 제공하여 더 나은 환자의 치료 결과를 이끄는 것입니다.
Cytiva는 글로벌 생명과학 리더로서, 삶을 변화시키는 치료법에 접근하여 인류의 건강을 증진시키고자 하는 비전에 전념하고 있습니다. Cytiva는 다양한 규모와 범위의 고객에게 신뢰할 수 있는 파트너로서, 연구 및 제조 워크플로우에 효율성을 제공하여 혁신적인 의약품의 개발과 제조, 그리고 환자에게 이를 전달하는 것을 보장합니다.

Cytiva Korea는 국내 바이오 기업들의 전문 기술력 육성에 대한 고민을 해결하는 데 도움을 주기 위해 <대한민국 바이오의약품 대상> 공모전을 후원하고 있습니다. 바이오의약품 개발 인프라 부족으로 어려움을 겪는 국내기업들을 대상으로 Cytiva의 제품과 패스트트랙센터 (Fast Trak Center)의 기술력을 함께 지원합니다. 배양/정제 공정 스크리닝, 공정 최적화, 공정 스케일업, 비임상시료 생산 등 제품 생산 전반에 걸쳐 제조공정 연구 및 양산에 도움을 드리려고 합니다.

대표기술

기술명	세포 배양 및 단백질 분리 정제를 위한 크로마토그래피 (chromatography) 기술

기술 개요

Cytiva만의 축적된 노하우를 바탕으로 바이오 의약품의 세포 배양/정제 공정 개발 및 스케일업, 분석법 개발, 기술이전, 미국 본사 cGMP 시설과 연계한 임상 시료 및 상업 생산을 지원합니다.
Cytiva의 목표는 특히 FAST TRAK center를 이용하여 고객이 직면한 공정상의 문제들을 해결하도록 도와주고 지원하는 것입니다.

기술 세부 내용

세포 배양의 기술은 싱글유즈 (Single-use) 장비를 이용한 바이오리액터 활용 및 업스트림 공정 개발 전략을 다룹니다. 공정 최적화 및 스케일-업을 위한 중요 변수 전반에 대한 것입니다. ReadyToProcess WAVE는 single-use bag 내부의 용액 움직임에 의한 믹싱 및 기체 전달 기능을 극대화한 single-use rocking bioreactor입니다. 세포 건강에 악영향을 주는 shear stress가 적고 single-use bag 사용으로 교차 오염 위험이 없어 연구 단계나 GMP 초기 종배양에 적합한 기술입니다.
Xcellerex bioreactor는 single-use 전문 브랜드로 바이오 의약품 개발, 생산 및 상용화 방식을 혁신하고 있습니다. 독창적인 바이오의약품 생산 플랫폼을 기반으로 구축된 혁신적인 single-use 어플리케이션 기술을 적용합니다.
단백질 분리 정제 (Protein purification)를 위한 기술과 방법의 개발은 생물공학분야에서 많은 발전을 위한 필수적인 전제조건이 되어져 왔다. 단백질 분리 정제는 간단한 one-step purification 과정에서부터 증명된 대량 정제의 생산 과정에까지 다양하다. 원하는 purity를 얻기 위해서는 종종 한번의 정제 과정 이상이 필요로 되어진다. 성공적인 단백질 정제는 적절한 technique을 선택하고, 그 방법으로 최상의 결과가 나오도록 optimization 하고, 수율 (yield)은 최대로 얻고 요구되는 정제 단계를 최소로 하는 것이다. 대부분의 단백질 정제는 크로마토그래피 (chromatography) 방법을 포함한다. 그 결과로 크로마토그래피는 단백질 정제를 위한 가장 필수적인 기술이다.

기술활용 범위

바이오 공정의 재조합 단백질, 항체, 백신 개발 및 생산을 위한 세포 배양 및 단백질 정제를 위한 분야에 폭넓게 사용되고 있으며, 또한 유전자 및 세로치료제 분야에 있어서도 배양 및 정제 기술을 활용하는 연구 및 생산에 적용되고 있습니다.

[S2-3] 학술대상 수상기념특강
Jeewon LEE Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV	Optimally Fabricated Platforms for Enhanced Cancer Therapy Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

[S2-3] 학술대상 수상기념특강

Jeewon LEE
Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV

Optimally Fabricated Platforms for Enhanced Cancer Therapy

Human heavy chain ferritin (huHF), iron-free apoferritin is a homo-multimer consisting of 24 heavy chain subunits that are self-assembled inside cells and has a nanoscale 3D structure (spherical particle with a diameter of 12 nm). It is worthy of noting that huHF is a highly-ordered, stable, and flexibly guest-adaptable protein and thus an excellent platform that can be used for constructing novel 3D biostructures. That is, beneficial integration and/or reassembly of diverse functional peptides or polypeptides on huHF platform with preserving its native self-assembly function can lead to optimal fabrication of innovative 3D biostructures that resolve problems that yet remain a major challenge in a wide range of area. In particular, huHF has a specific and strong affinity for transferrin receptors on dendritic cells, suggesting that optimal integration of tumorꠓspecific antigens (TSA) into huHF and administration of the TSA-integrated huHF guide efficient activation of tumor-specific anti-tumor immunity in the body. Further, huHF platform enables high-capacity loading and cancer cell-specific activation of various chemotherapeutic drugs such as doxorubicin, mitomycin C, and gemcitabine that are still clinically useful for cancer treatment. Despite considerable therapeutic efficacy, severe toxicity-associated problems of the chemotherapeutic drugs, which are mainly caused by the non-specific mode of action such as chromosomal DNA damage and/or interference in the DNA replication even in normal cells, remain unresolved. Here I introduce recent important results of my research team in the huHF platformꠓbased cancer immuno- and chemotherapy, showing that both drug toxicity and efficacy in in vivo cancer treatment were dramatically enhanced. This approach is expected to open up a novel clinical route to break through the limits of and thus bring about safer and more widespread adoption of current cancer therapy.

Development of Fermentation Starters in Food Industry		ProfessorDae-Hyuk KweonSungkyunkwan University, Korea
Instruction	Fermentation starters assist the beginning of the fermentation process in preparation of various foods and alcoholic drinks. Starter culture generally comprises bacteria, yeasts, moulds or their combination. Among them, lactic acid bacteria and yeasts play a major role in fermentation. Advantageous characteristics of starter cultures involve faster acidification, expectable fermentation activities and desired sensory (aroma, consistency, taste and texture) and safety properties. Recent scientific methods have formulated functional starter cultures, which offer at least one functional trait to enhance the nutrition, quality or safety of the food product. In this symposium, starters for Kimchi, beer, bread, makgeoli and their state-of-art engineering tools are discussed.
Speaker	Affiliation	Title
	Invited Speaker Professor/CTO Yong-Cheol Park Department of Bio and Fermentation Convergence Technology, Kookmin University / Biocraft Co., Korea CV	Development of Alcohol Yeasts for Beer Brewing
	Invited Speaker Director of Research Woo-Chang Shin Kooksoondang Brewery co., Ltd., Korea CV	Success Stories in the Brewing Industry Using Korean Fermentation Starters
	Invited Speaker Team manager/ General Manager Byung Hee Ryu Department of Food Research, Daesang Co., Ltd, Korea CV	Fermentation Characteristics of Kimchi Lactic Acid Bacteria Starters
	Keynote Speaker Professor Yong-Su Jin University of Illinois at Urbana-Champaign, USA CV	Genome-edited Saccharomyces cerevisiae Strains for Improving Quality, Safety, and Flavor of Fermented Foods

Co-organized by

Synthetic Biology Tools for Microorganisms		Professor Sang Woo SeoSeoul National University, Korea
Instruction	Synthetic biology has created a new paradigm to engineer microorganisms for various applications including industrial biotechnology, environmental biotechnology, energy, food & agriculture, and health & medicine. In this symposium, we will discuss recent progress in the development of synthetic biology tools for microorganisms including genetic circuits, high-throughput screening tools, and their practical applications.
Speaker	Affiliation	Title
	Keynote Speaker Professor Tae Seok Moon Washington University in St. Louis, USA CV	Systems and synthetic biology: constructing smart and programmable microbes
	Invited Speaker Professor Gyoo Yeol Jung POSTECH, Korea CV	Synthetic biology for advanced bioprocess: novel enzymes, pathway, and cell-cell communications
	Invited Speaker Professor Haseong Kim Korea Research Institute of Bioscience and Biotechnology, Korea CV	A high-throughput part characterization tool with long-read sequencing technique
	Keynote Speaker Professor Tom Ellis Imperial College London, UK CV	Synthetic Yeast Genomes Beyond Sc2.0: Synthetic Clusters

Co-organized by

Recent Applications of Bioelectrochemical Technology for Sustainable Energy and Environment		Professor Changsoo LeeDepartment of Urban and Environmental Engineering, UNIST Professor Jaewook MyungDepartment of Civil and Environmental Engineering, KAIST
Instruction	Electrochemically active bacteria use an extracellular electron transport mechanism, and they have been widely applied for bioenergy generation, biosensing and environmental bioremediation. Bioelectroochemical systems (BESs) using such strains as biocatalyst, have been highlighted for bioelectricity production and novel conversion process of biomass/C1 gas feedstocks to value-added chemicals in the form of microbial fuel cells (MFCs) and microbial electrosynthesis cell. Bioelectrochemical technology also have been applied to regulate bacterial redox state and respiratory chain to control fermentation and bioconversion processes. In this international symposium, we invite four prominent experts in this field, and will overview the recent progress of bioelectrochemical technology, as well as its various applications in the field of energy and environment.
Speaker	Affiliation	Title
	Invited Speaker Associate Professor Younggy Kim Department of Civil Engineering, McMaster University, Canada CV	Pb(II) Reducing Bacteria: Isolation, Identification, and Characterization
	Invited Speaker Assistant Professor Bongkyu Kim Division of Biotechnology, Jeonbuk National University, Korea CV	Microbial Electrochemical Process for Bioremediation of Recalcitrant Contaminants in Soil and Water
	Invited Speaker Assistant Professor Changman Kim Dept. Biotechnology and Bioengineering, Chonnam National University, Korea CV	Electro-chemical Interaction: Exogenic and Synthetic Pathway for Bioproduction
	Keynote Speaker Professor Seokheun Choi Department of Electrical & Computer Engineering, State University of New York at Binghamton, USA CV	Bacteria-Powered Batteries

Co-organized by

Recent Advances in Metabolic Engineering I		Professor Byung-Kwan ChoDepartment of Biological Sciences, KAIST, Korea
Instruction	Metabolic engineering has created a new paradigm to engineer microorganisms for efficient production of desired bio-products. In this symposium, we will introduce recent advances in the development of such platform technologies and chemical producers based on various microorganisms such as E. coli, Corynebacterium, yeast, and so on.
Speaker	Affiliation	Title
	SBJ Invited Speaker Professor Haruko Takeyama Waseda University, Tokyo, Japan CV	The Challenge of Revealing the Identity of Functionally Unknown Environmental Microbes: What We Can See from Single-cell Level Analysis
	Keynote Speaker Professor Mattheos Koffas Rensselaer Polytechnic Institute, New York, USA CV	The road to animal free sulfated glycosaminoglycans: production of chondroitin and heparin using recombinant bacteria
	Invited Speaker Professor Min-Kyu Oh Korea University, Seoul, Korea CV	Metabolic Engineering for Efficiently Utilizing Various Carbon Sources
	Invited Speaker Professor Si Jae Park Ewha Womans University, Seoul, Korea CV	Development of Metabolically Engineered Corynebacterium Glutamicum for Biorefinery

Recent Advances in Metabolic Engineering II		Professor Byung-Kwan ChoDepartment of Biological Sciences, KAIST, Korea
Instruction	Metabolic engineering has created a new paradigm to engineer microorganisms for efficient production of desired bio-products. In this symposium, we will introduce recent advances in the development of such platform technologies and chemical producers based on various microorganisms such as E. coli, Corynebacterium, yeast, and so on.
Speaker	Affiliation	Title
	Invited Speaker Professor Sung Kuk Lee Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea CV	Gene Expression Systems in Pseudomonas putida: an Alternative Microbial Cell Factory for Production of Platform Chemicals
	Invited Speaker Professor Seon-Won Kim Gyeongsang National University, Jinju, Korea CV	Production of non-natural acetins from glycerol using metabolically engineered Escherichia coli
	Invited Speaker Professor Ji-Sook Hahn Seoul National University, Seoul, Korea CV	Differential Regulation of Weak Organic acid Tolerance by WatR Transcription Factor in Methylomonas sp. DH-1
	Invited Speaker Professor Ki Jun Jeong KAIST, Daejeon, Korea CV	Engineering of Klebsiella Oxytoca for Production of 2,3-butanediol from Multiple Sugars

Co-organized by

Stem Cell Engineering & Nanobiotechnology I		Professor Jeong-Woo Choi Department of Chemical and Biomolecular Engineering, Sogang University, Korea
Instruction	Stem cell engineering is an emerging multi-disciplinary research field that involves expertise related to stem cell biology, micro/nanoscale engineering, and medicine. Engineering regenerative tissues are of great benefit for restoring the lost function of diseased or damaged organs. The current research trends of stem cell engineering aim to integrate micro/nanoscale engineering platforms, stem cell-encapsulated biodegradable scaffolds, stem cell therapy, and regenerative medicine. In this symposium, we will discuss various state-of-the-art technologies, drug delivery, regenerative therapy, and cancer immunotherapy. (This symposium is supported by Institute of Integrated Biotechnology and BK21 plus (Center for Molecular-scale control in chemical and biological engineering) in Sogang University)
Speaker	Affiliation	Title
	Invited Speaker Professor Mee-Hae KIM Osaka University, Japan CV	Bioengineering Considerations for a Nurturing Way to Improve Expansion of Pluripotent Stem Cells
	Invited Speaker Professor Wooram Park Catholic University of Korea, Korea CV	Combination of Functional Nano-adjuvant with Electrical Ablation for Effective Local Cancer Immunotherapy
	Invited Speaker Professor Jianshing Yu National Taiwan University, Taiwan CV	Keratin-based Nanoparticles with Tumor-Targeting and Cascade Catalytic Capabilities for the Combinational Oxidation Phototherapy of Breast Cancer
	Invited Speaker Professor Bong Geun Chung Sogang University, Korea CV	Micro/Nanotechnology Systems for Neural Stem Cell Differentiation

Stem Cell Engineering & Nanobiotechnology II		Professor Taewook KangDepartment of Chemical and Biomolecular Engineering, Sogang University, Korea
Instruction	Nanomaterials are a potential and promising candidate in biomedical fields, including precise and sensitive diagnosis of fetal diseases and practical therapeutic applications. Their inherent functionalities, such as biocompatibility, biodegradability, passive and active targeting properties, and signal amplification for imaging and sensing, can be applied to enhance the diagnostic and therapeutic effects. In this symposium, we will discuss nanobio-engineering strategies for developing sensitive biosensors to detect viral diseases and effective therapeutics against cancers. (This symposium is supported by the BK21 plus program from Sogang university)
Speaker	Affiliation	Title
	Keynote Speaker Professor Young Jik Kwon University of California, U.S.A CV	Multi-modal Gene and Chemotherapy: Biologically-targeted, Universally-adaptable, and Synergistic Therapy for Cancer
	Keynote Speaker Professor Joon Myong Song Seoul National University, Korea CV	Transparent Tumor Imaging
	Invited Speaker Professor Young L. Kim Purdue University, USA CV	Silk is a Biomedical Metamaterial: An Oxymoron?
	Invited Speaker Professor Jin-Ha Choi Jeonbuk National University, Korea CV	CRISPR-Cas12a-assisted Multi-Viral DNA Detection by the Surface-Enhanced Raman Scattering (SERS)-based Triangle Au Nanoflower Substrate

Co-organized by

Synthetic Biology for DNA memory		Dr. Dae-Hee LeeKorea Research Institute of Bioscience and Biotechnology, Korea
Instruction	DNA is the primary information storage medium in living organisms and can be used in synthetic cellular memory devices that convert biological signals into heritable changes in nucleotide sequences. Approaches using recombinases, single-stranded DNA recombineering, and CRISPR-Cas9 have been developed to record the level of a biological signal or to track developmental lineage. In this symposium, we will discuss recent progress in the DNA-based memory devices, which includes cellular recording using CRISPR technologies, scalable DNA-based information storage, and design of DNA sequences for information storage (This symposium is co-organized by Korea Research Institute of Bioscience and Biotechnology)
Speaker	Affiliation	Title
	Keynote Speaker Professor Harris H. Wang Columbia University, New York, USA CV	Cellular recording using CRISPR technologies
	Invited Speaker Principal Researcher Dae-Hee Lee Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea CV	DNA-based Recording System for Gut Inflammation
	Keynote Speaker Professor Albert Keung North Carolina State University, Raleigh, USA CV	Scalable DNA-Based Information Storage
	Invited Speaker Professor Hosung Park Chonnam National University, Gwangju, Korea CV	Joint Design of Sequence Clustering, Alignment, and Decoding for DNA Storage

Co-organized by

Cell-free Synthetic Biology and DNA nanotechnology		Professor Jeong Wook LeePOSTECH
Instruction	Cell-free synthetic biology has recently emerged as a subfield of synthetic biology and involves the construction and characterization of biological systems in a cell-free environment. The flexibility to build and characterize biological systems is accelerating advances in synthetic biology. In this symposium, we will discuss recent progress in cell-free synthetic biology for a wide variety of applications including diagnostics, sensors, and DNA/Protein nanomaterials
Speaker	Affiliation	Title
	Keynote Speaker Professor Michael C. Jewett Northwestern University, Evanston, USA CV	Bioengineering beyond Cells to enable a fair and sustainable 21st bio-century
	Invited Speaker Professor Dong-Myung Kim Chungnam National University, Daejeon, Korea CV	Designing Cell-Free Biology for Analysis and Diagnosis
	Invited Speaker Associate Professor Seung Soo Oh Pohang University of Science and Technology (POSTECH), Pohang, Korea CV	In vitro selection of nucleic acid modules with complex functionalities for synthetic biology
	Invited Speaker Professor Cheulhee Jung Korea University, Seoul, Korea CV	A stochastic DNA walker that traverses a microparticle surface

Co-organized by

AI-assisted Bioprocess Development		Professor Jeong Wook LeeDepartment of Chemical Engineering, POSTECH, Korea
Instruction	Biological processes have multi-scale nature consisting of microbial metabolic reactions, the interaction between the cells in the reactor, and the overall plant with various unit processes. These complex and non-linear characteristics make the analysis of bioprocesses very difficult, thus hindering to find the optimal solution based on engineering research. Artificial intelligence (AI) is now maturing to the point where it promises to help solve many problems in meaningful new ways. So far, the AI approaches have been successfully used in bioindustries, e.g., drug design. In this international symposium with two Japanese researchers from SBJ (The Society for Biotechnology, Japan), we will discuss the state-of-the-art results of bioprocess development assisted by machine learning. Various applications, including metabolic characterization and engineering, culture media design, and process modeling, are presented.
Speaker	Affiliation	Title
	SBJ Invited Speaker Senior Researcher Muneyoshi Kanai National Research Institute of Brewing (NRIB), Japan CV	Analysis of Functional Ingredient Accumulation Mechanism and Application in Sake Yeast
	Invited Speaker Assistant Professor Hyun Uk Kim KAIST, Korea CV	Characterization and Engineering of Microbial Metabolism Using Deep Learning
	SBJ Invited Speaker Professor Massaki Konishi Kitami Institute of Technology, Japan CV	Culture Medium Profiling and Design Assisted by Machine Learning
	Invited Speaker Principal Researcher Junghwan Kim Korea Institute of Industrial Technology, Korea CV	Machine Learning-based Predictive Models of Chemical Process

Co-organized by

mRNA Vaccines		Prof. Donghyuk KimUlsan National Institute of Science and Technology, Ulsan, Korea
Instruction	mRNA vaccines combine desirable immunological properties with an outstanding safety profile and the unmet flexibility of genetic vaccines. Based on in situ protein expression, mRNA vaccines are capable of inducing a balanced immune response comprising both cellular and humoral immunity. In addition, mRNA is an intrinsically safe vector as it is a minimal and only transient carrier of information that does not interact with the genome. In this symposium, we will discuss enabling technologies that have been recently developed to enable mRNA vaccines and related materials.
Speaker	Affiliation	Title
	Invited Speaker Professor Hyukjin Lee Ewha Womans University, Seoul, Korea CV	Development of RNA Therapeutics and Lipid Nanoparticle (LNP) Formulation for in vivo Delivery
	Invited Speaker Professor Yoosik Kim Korea Advanced Institute of Science and Technology, Daejeon, Korea CV	Utilizing MicroRNAs for Self-modulating RNA Therapy
	Invited Speaker Associate Professor Young-Kook Kim Chonnam National University Medical School, Hwasun, Korea CV	RNA Therapy: Current Status and Future Potential
	Invited Speaker Associate Professor Hyungjin Kim Inha University, Incheon, Korea CV	Amphiphilic Polyaspartamide Derivatives for mRNA Delivery and Their Application for CRISPR-Cas Technology

Co-organized by

Metabolic Studies Meet Protein Engineering I		Prof. Si Jae ParkDivision of Chemical Engineering and Materials Science, Ewha Womans University, Korea Prof. Young Joo YeonDepartment of Biochemical Engineering, Gangneung-Wonju National University, Korea
Instruction	The era of the 4th industrial revolution requires cooperation and convergence between related research areas as well as individual technology fields for innovative development. A joint session between synthetic/metabolic biotechnology and protein/enzyme engineering has been proposed, as greater advances in synthetic biology could come through a better understanding of the properties of enzymes/proteins involved in cellular metabolism and metabolic pathways. In this session, current achievements and future prospects in the fields of metabolic pathway research, synthetic biology, metabolic engineering and protein/enzyme engineering will be discussed.
Speaker	Affiliation	Title
	Invited Speaker Professor Kyoung Heon Kim Department of Food Bioscience and Technology, Korea University, Korea CV	Sustainable Biological Production and Upcycling of Plastics Using Metabolic and Enzyme Engineering Approaches
	Invited Speaker Professor Kwon-Young Choi Department of Environmental Engineering, Ajou University, Korea CV	Enzyme Engineering and Cell Factories for the Production of Microbial Colorants in Eshcerichia coli
	Invited Speaker Professor Tae Hyeon Yoo Department of Molecular Science and Technology, Ajou University, Korea CV	Synthetic Biology Approaches to Engineer Orthogonal Translation Systems for the Site-specific Incorporation of Noncanonical Amino Acids
	Invited Speaker Professor Hyungdon Yun Department of Systems Biotechnology, Konkuk University, Korea CV	Creation of (R)-β-Transaminase Not Yet Found in Nature by Directed Evolution of D-amino Acid Aminotransferase

Metabolic Studies Meet Protein Engineering II		Prof. Si Jae ParkDivision of Chemical Engineering and Materials Science, Ewha Womans University, Korea Prof. Young Joo YeonDepartment of Biochemical Engineering, Gangneung-Wonju National University, Korea
Instruction	The era of the 4th industrial revolution requires cooperation and convergence between related research areas as well as individual technology fields for innovative development. A joint session between synthetic/metabolic biotechnology and protein/enzyme engineering has been proposed, as greater advances in synthetic biology could come through a better understanding of the properties of enzymes/proteins involved in cellular metabolism and metabolic pathways. In this session, current achievements and future prospects in the fields of metabolic pathway research, synthetic biology, metabolic engineering and protein/enzyme engineering will be discussed.
	Invited Speaker Professor Byung-Kwan Cho Department of Biological Sciences and KI for the BioCentury, Korea Advanced Institute of Science and Technology, Korea CV	Genome Design Principles Derived from In Silico Modeling and Evolutionary Reprogramming
	Invited Speaker Professor Soo-Jin Yeom School of Biological Sciences and Technology, Chonnam National University, Korea CV	Discovery of Nnew Biocatalyst for Plastic Biodegradation and Future Directions
	Invited Speaker Professor Hahk-Soo Kang Department of Biomedical Science and Engineering, Konkuk University, Korea CV	Stepwise Engineering of Biosynthetic Gene Cluster for Titer Improvement of Clinically Important Antibiotic Daptomycin in Streptomyces roseosporus
	Invited Speaker Professor Jeong Eun Hyeon Department of Food Science and Biotechnology, Sungshin Women’s University, Korea CV	Biomimetic Strategies of Artificial Enzyme Complexes to Produce Microbial Substrates for Synthetic Biology

Accomplishment presentation of Bioindustry Alliance and Cooperation Council for Materials, Components and Equipments I		Prof. Gyunmin LeeKAIST, Korea
Instruction	Presentation of Accomplishment according to National BIO R&D project of Serum-free and cell-specific media in cells(CHO, therapeutic), Media Additives, Cell cryopreservation media(DMSO free), Culture media grinding mixture formulation technology, Single use bag for Bioprocessing, Single use bag Film
Speaker	Affiliation	Title
	교수 이균민 KAIST, Korea CV	개회사 및 과제 개요 소개
	전무 유원규 에이비엘바이오 CV	맞춤형 배지 R&D 추진 현황
	상무 박정수 팬젠 CV	배양 배지 첨가물 R&D 추진 현황
	이사 민보경 GC녹십자랩셀 CV	세포치료제 동결보존 조성물 R&D 추진 현황
	본부장 최수림 아미코젠 CV	분쇄혼합제형화기술 R&D 추진 현황
	팀장 박기호 동원시스템즈 CV	일회용백 제작을 위한 필름 R&D 추진 현황
	대표 김두현 이셀 CV	일회용 저장백 및 어셈블리 R&D 추진 현황

Accomplishment presentation of Bioindustry Alliance and Cooperation Council for Materials, Components and Equipments II		Prof. Dongil KimInha University, Korea
Instruction	Presentation of Accomplishment according to National BIO R&D project of TOC vial, NaOH, IPA, Formalin, Non-invasive sensor, pH-DO sensor
Speaker	Affiliation	Title
	교수 김동일 인하대학교 CV	개회사 및 과제 개요 소개
	연구소장 최철호 동신관유리공업 CV	TOC 테스트 및 샘플링용 저농도 인증 바이알 R&D 추진 현황
	책임 구본무 바이옥스 CV	바이오의약품 생산용 NaOH 정제기술 R&D 추진 현황
	이사 박성삼 덕산약품공업 CV	바이오의약품 생산용 IPA 정제기술 R&D 추진 현황
	소장 김우선 켐바이오 CV	바이오의약품 생산용 Formalin 정제기술 R&D 추진 현황
	대표 박종택 씨맥 CV	프로브형 pH, DO센서 및 모니터링 기술 R&D 추진 현황
	책임 김동훈 에스피엘 CV	비침습적 센서 및 실시간 세포농도 모니터링 기술 R&D 추진 현황

Co-organized by

KSBB Daegu-Gyeongbuk Regional Symposium		Prof. Eun Jung LeeDepartment of Chemical Engineering, Kyungpook National University, Korea
Instruction	KSBB Daegu-Gyeongbuk Regional Symposium
Speaker	Affiliation	Title
	Keynote Speaker Professor Joong Kon Park Department of Chemical Engineering, Kyungpook National University, Korea CV	Production and Industrial Application of Bacterial Cellulose
	Invited Speaker Professor Jae Bem You Department of Chemical Engineering, Kyungpook National University, Korea CV	Microfluidic Sperm Selection and Analysis
	Invited Speaker Senior Researcher Jeewoong Park Advanced Technology Department, Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea CV	Acoustophoretic Microfluidics for Efficient Separation and Stringent Washing
	Invited Speaker Professor Joongoo Lee Department of Chemical Engineering, Pohang University of Science and Technology, Korea CV	Engineering Molecular Translation Systems
	Invited Speaker Professor Young Ki Hahn Biomedical Convergence Science & Technology, Kyungpook National University, Korea CV	Magnetophoretic Assay System based on the Microfluidics for Point-of-care Diagnostics

Co-organized by

개량의약품 협력 협의체 기술교류회		SKKU
Instruction	ㅇ (목적) 개량의약품 분야 산․학․연 연구자 간 기술교류를 통한 R&D 성과공유 및 사업 운영 내실화 ㅇ 주요내용 - (기술교류) 협의체 참여기관 간 과제별 R&D 추진현황에 대한 기술교류 - (운영방안 논의) 개량의약품 R&D 협의체 연차별 운영방안 논의
Speaker	Affiliation	Title
	상무 엄승인 한국제약바이오협회	바이오의약품 신규제형 기반 개량의약 제품화 기술개발 글로벌 진출형 차세대 바이오베터 기술개발 및 제품화 지원
	대표 허경화 (재)한국혁신의약품컨소시엄	글로벌 진출형 제형기술기반 개량의약제품 개발

Co-organized by

Young Scientist Forum I		Prof. Gwi-Taek JeongDepartment of Biotechnology, Pukyong National University
Instruction	In this symposium, The invited young scientists will present their current research progress. Through this session, we can share the most recent advances on Metabolic Engineering, Systems Biology, and Structural Biology
Speaker	Affiliation	Title
	Invited Speaker Assistant Professor Jong Min Lee Department of Biotechnology, Pukyung National University, Busan, Korea CV	A Glycosylated-Metabolite β-Gentiobiosylpaeoniflorin of Paeonia Lactiflora bioconverted by Leuconostoc sp. Alleviates Metabolic Syndrome in High Fat Diet-fed Mice
	Invited Speaker Senior Engineer Sun-A Choi Energy Resources Upcycling Research Laboratory, Korea Institute of Energy Research, Daejeon, Korea CV	Enhancement of High Value-added Products from Microalgal Biomass
	Invited Speaker Researcher Jung Ho Ahn Clean Energy Research Center, Korea Institute of Science and Technology, Seoul, Korea CV	Biosuccinic Acid Production Technology for Bioplastic Economy
	Invited Speaker Assistant Professor Hae-Min Park Department of Chemical Engineering and Applied Chemistry, Chungnam National University, Daejeon, Korea CV	A New Analytical Platform for Faster Protein Analysis
	Invited Speaker Assistant Professor Jeong Min Chung Department of Biotechnology, The Catholic University of Korea, Bucheon, Korea CV	Advanced Cryo-Electron Microscopy Technology: High Resolution Structure of Membrane Spanning Macromolecular Nanomachines

Young Scientist Forum II		Dr. Eun Jeong KimCenter of R&D Feasibility Analysis, KISTEP Prof. Dong Soo HwangDivision of Environmental Science and Engineering, POSTECH
Instruction	In this symposium, The invited young scientists will present their current research progress. Through this session, we can share the most recent advances on Biomedical & Biopharmaceutical Engineering and Biomaterials
Speaker	Affiliation	Title
	Invited Speaker Assistant Professor Byoung Joon Ko Sungshin Women's University, Seoul, Korea CV	Physicochemical and Structural Characterization of Biopharmaceuticals
	Invited Speaker Assistant Professor Raehyun Kim Department of Biological and Chemical Engineering, Hongik University, Sejong, Korea CV	A Novel In Vitro Human Colon Model System for Investigating Interaction of Gut Microbes with Human Cells
	Invited Speaker Assistant Professor Sang Jun Han Department of Biotechnology, Pukyong National University, Busan, Korea. CV	Renal NFκB Essential Modulator (NEMO) Mediates Ischemic Acute Kidney Injury in Mice
	Invited Speaker Senior Researcher Hyo Jeong Kim Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan, Korea CV	Functional Adhesives: from Medical to Eco-friendly Adhesives
	Invited Speaker Assistant Professor Kisuk Yang Division of Bioengineering, Incheon National University, Incheon, Korea CV	A Therapeutic 3D Device for Enhancing Stem Cell Derived β Cell Viability and Function

Biomedical Engineering		Prof. Yong Woo ChoDepartment of Materials Science and Chemical Engineering, Hanyang University ERICA, Korea Prof. Seung-Woo ChoDepartment of Biotechnology, Yonsei University, Korea
Instruction	This session aims to introduce various biomedical engineering strategies to develop novel therapeutics, biomaterials scaffolds, and disease models for regenerative medicine. Recent research progress on development and applications of biomedical engineering platforms such as exosomes, microfluidics, hydrogels, and 3D printing will be presented in the session.
Speaker	Affiliation	Title
	Invited Speaker Professor Yong Woo Cho Department of Materials Science and Chemical Engineering, Hanyang University ERICA & ExoStemTech Inc. CV	Development of Stem Cell Exosome Therapeutics from Bench to Bedside
	Invited Speaker Professor Seung-Woo Cho Department of Biotechnology, Yonsei University CV	Brain-on-a-chip for Disease Modelling
	Invited Speaker Professor Nathaniel HWANG School of Chemical and Biological Engineering, Seoul National University CV	Enzymatic Crosslinking-based Hydrogel Nanofilm for Immunoisolation
	Invited Speaker Associate Professor Jinah Jang Department of Creative IT Engineering, Pohang University of Science and Technology (POSTECH) CV	Extracellular Matrix-derived Printable Biomaterials for Engineering Physiomimetic Human Tissues
	Invited Speaker Assistant Professor Wonhwa Lee Sungkyunkwan University CV	Research on Theragnostic Biomaterials for Severe COVID-19

Special Symposium Honoring Professor Seung Wook Kim for His Retirement		Prof. Chulhwan ParkDepartment of Chemical Engineering, Kwangwoon University, Seoul, Korea Assistant Prof. Hah Young YooDepartment of Biotechnology, Sangmyung University, Seoul, Korea
Instruction	We are holding a special symposium on retirement by Professor Seung Wook Kim, who has dedicated his life to nurture and educate juniors at university and has made outstanding achievements in the development of bioprocess engineering. In this symposium, we invite professor Seung Wook Kim and four prominent speakers in the field of biotechnology and will overview the recent developments in industrial biotechnology, as well as its various applications in the field of biohealthcare, biochip, and genetic engineering.
Speaker	Affiliation	Title
	Invited Speaker Professor Jeong-Woo Choi Department of Chemical and Biomolecular Engineering, Sogang University, Korea CV	Nanobioelectonic Device toward Human-on-a Chip and Biohybrid Robot
	Invited Speaker Professor Jeewon Lee Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV	Highly Efficient Genetic Toolbox for Active Recombinant Protein Synthesis
	Invited Speaker Vice President Chang Ho Kim PharmaResearch BIO Co., Ltd. CV	The Importance of Data Integrity in Bio-industry
	Invited Speaker Professor Tai Hyun Park The School of Chemical and Biological Engineering, Seoul National University, Korea CV	GPCR-Nanodisc Platform for Therapeutic Antibody Screening
	Invited Speaker Professor Seung Wook KIM Department of Chemical and Biological Engineering, Korea University, Seoul, Korea CV	Development of various biological processes for their application in industry

Co-organized by

CJ BIO R&D : Open Innovation & Recruitment Program		R&D Planning Team Lead Kwang-Woo Lee (Ph.D.)Institute of Biotechnology, CJ CheilJedang, Korea
Instruction	CJ CheilJedang has two business divisions; Food and BIO, and CJ BIO has led business globalization at the front of CJ Group since 1960. CJ BIO business is not as famous as CJ food business are, because of its B2B business model. However, CJ BIO is one of major leaders in the global BIO fermentation industry. The goal of CJ BIO is providing innovative biotech products and solutions for sustainable global society. CJ BIO is focusing on securing sustainable products portfolio and breakthrough technologies to satisfy ESG management. In this session, the head of institute of biotechnology, Seokhwan Yoon(SKY), will introduce CJ BIO business and its Open Innovation opportunities, Yong-UK Shin will present CJ BIO Automation and Digital transformation, and HR professional, Chaehee Park, will introduce the process and plan of CJ BIO recruitment.
Speaker	Affiliation	Title
	Keynote Speaker Sr. Vice President Seokhwan Yoon (SKY) Institute of Biotechnology, CJ CheilJedang	CJ BIO Overview & Open Innovation
	Keynote Speaker Sr. Vice President Yong-Uk Shin Institute of Biotechnology, CJ CheilJedang	CJ BIO Automation & Digital transformation
	Invited Speaker HR Professional Chaehee Park BIO HR, CJ CheilJedang	CJ BIO Recruitment

Co-organized by

Convergence of Antibody Engineering and Nano-biotechnology in Drug Delivery and Diagnostics		CTO/ R&D Director Dae Young KimPnP Biopharm Co., Ltd., Korea Prof. Min-Gon KimGwangju Institute of Science and Technology (GIST), Korea
Instruction	Antibody engineering is a part of protein engineering which broadly ranges from antibody discovery technology such as phage and yeast surface display, through bispecific antibody technology, to cell and immunotherapy such as CAR-T and immunechckpoint inhibitors. Due to the unprecedentedly rapid growth of nanotechnology, which deals with nanometer-scale objects applicable to diverse fields, throughout the past years, antibody engineering field has been expanding to a new direction by adopting the nanotechnology, resulting in creating a novel area which has proved its tremendous impacts in therapeutics and diagnostics. In this session, we will discuss recent trends in this unique nano-biotechnological field, focusing on nano-therapeutics, drug delivery and diagnostics.
Speaker	Affiliation	Title
	Invited Speaker CEO Jinyeop Lee KingoBio Inc., Korea CV	Automated Sample Preparation Platform Improving Sensitivity of Molecular Diagnostics for Infectious Diseases
	Invited Speaker Head of R&D Weon-Kyoo You ABL BIO Inc., Korea CV	Development and Application of a Bispecific Antibody Penetrating the Blood-brain-barrier (BBB)
	Invited Speaker Associate Professor Ji Ho Park KAIST, Korea CV	Nanomedicine for the Treatment of Atherosclerosis
	Invited Speaker Assistant Professor Hyeon-Yeol Cho Kookmin University, Korea CV	Biodegradable Self-guided Nanomedicine Delivery Platform

Co-organized by

바이오위해평가 원팀 리노베이션사업 소개 및 홍보		센터장 김기철한국생명공학연구원 본부장 노영희한국생명공학연구원
Instruction	한국생물공학회에서는 한국생명공학연구원 바이오안전성정보센터 및 국가연구안전관리본부의 지원을 받아 유전자변형기술/유전자가위기술 유래 산물의 사업화 촉진을 위해 추진 중인 “바이오위해평가 원팀 리노베이션사업(2021-2023)”을 소개하고 공유하고자 함. 이 사업은 논문·특허 수준에만 머물고 있는 유전자변형기술/유전자가위기술 유래 산물이 위해성평가/심사 장벽을 넘어 사업화까지 갈 수 있도록 바이오원팀(과기정통부, 산업부, 복지부)을 통한 관련 인프라 및 제도개선에 초점을 맞춤. 또한 전 세계적으로 바이오기술의 빠른 발전과 정부의 ‘탄소중립’, ‘화이트바이오산업 활성화 전략’정책 등을 고려해 학계/산업계가 관련 제품의 인·허가에 능동적으로 대응할 수 있도록 가이드 등을 제공하기 위함. 또한 해당 연구개발 및 사업화를 염두에 둔 학계/산업계 관련자들의 현장에서의 애로사항 등을 듣고 해당 사업에 적극적으로 반영 및 개선하고자 하며, 위해성평가/심사, 즉 안전관리에 기반한 사업화 추진은 바이오기술 유래 제품의 국민 안심도 및 수용성 증가, 글로벌 경쟁력 강화에도 기여할 수 있으니 많은 학회 참석자들의 관심 및 참여를 바람.
Speaker	Affiliation	Title
	Invited Speaker 팀장 송인자 한국생명공학연구원 국가연구안전관리본부 CV	바이오위해평가 원팀 리노베이션 사업 추진배경 및 과기정통부 사업 소개 (The Introduction of ‘Biorisk Assessment Renovation Project’ and Role of MSIT for LMO R&D Advancement)
	Invited Speaker 센터장 김기철 한국생명공학연구원 바이오안전성정보센터 CV	산업용 LMO 위해성평가 및 심사, 상업화 관련 산업부 지원 사업 소개 (An Introduction of the MOTIE Support Project for Risk Assessment and Review, commercialization of LMOs for Industrial Use)
	Invited Speaker 팀장 문건하 한국생명공학연구원 바이오안전성정보센터 CV	산업용 LMO 위해성심사 동향 및 전망 (Trends and Prospects of Risk Assessment for Industrial LMOs)

Co-organized by

국내 일반 특강		Professor / Kyobum KIM (Dongguk University, Korea)
Instruction	The biotechnology is receiving attention as one of the next-generation food industries in Korea. Biotechnology is broadly classified into white bio, green bio and red bio. Furthermore, we are making efforts to overcome existing technological limitations by incorporating biotechnology into the electronics industry. In this symposium, we will discuss how biotechnology can recently be applied to food, disease diagnosis, energy field, and antibiotic development.
Speaker	Affiliation	Title
	Professor Byeong Hee HWANG Incheon National University, Incheon, Korea	Nanocomplex-mediated Nucleic Acid Delivery for Gene Therapy
	Professor Chang- Hyung CHOI Daegu Haany University, Gyeongsan, Korea	Cell-Inspired Hydrogel Microcapsules Incorporating an Interstitial Oil Layer for Long-Term Retention of Highly Reactive Cargoes
	Professor Won Jong RHEE Incheon National University, Incheon, Korea	Harnessing Extracellular Vesicles for Biomedical Applications: Single-step Extracellular Vesicle Concentration Using Super Absorbent Polymer Beads
	Professor Kyung-Ha LEE Daegu Haany University, Gyeongsan, Korea	Dynamic Circadian Regulation and Modulator of Clock Genes in Skin Cells
	Professor Chung-Sung LEE Sun Moon University, Asan, Korea	Development of Oxygen-Carrying Nanoparticle for Bone regeneration

Future Trends in the Cosmetics Industry: The Role of Biotechnology		Prof. Yong Hwan KimSchool of Energy and Chemical Engineering, UNIST, Korea Prof. Sang Hyun LeeDept. of Biological Eng., Konkuk University, Korea
Instruction	Cosmetic companies have used biotechnological techniques to discover and manufacture active ingredients related to whitening, anti-oxidant, anti-aging, and UV-protection. In this symposium, we will introduce the current R&D trends and future prospects of cosmetics industry. The biotechnology will play an important role in the development of customized cosmetics, cosmeceuticals, microbiome cosmetics, and novel cosmetic formulation. (This symposium is supported by SMILE ERC center.)
Speaker	Affiliation	Title
	Invited Speaker Director Jun Bae Lee Innovation Lab, Cosmax R&I Center, Korea CV	Current R&D Trends and Future Prospects of the K-Beauty
	Invited Speaker Chief Researcher In Soo Suh Jeju Technopark, Bio Convergence Center, Korea CV	A Case Study of Customized Cosmetics and Future Development : Based on of Jeju Province Project
	Invited Speaker Director Wonsang Seo GFC Life Science, Korea CV	How to Increase the Chances of Successful Entry into Cosmetics for Pharmaceutical and Biotech Companies
	Invited Speaker Professor Sung-Kyu Hong Department of Chemical and Biochemical Engineering, Dongguk University, Korea CV	Human Skin Analysis on the basis of Skin Optical Spectrum

Co-organized by

바이오 데이터 엔지니어 인력양성사업 성과발표회		Prof. 하석진강원대학교 Prof. 신수임전남대학교
Instruction	4차 산업혁명에 따라 산업계는 데이터 기반의 제품 및 서비스 개발이 점차 가속화되고 있음. 기초연구 현장에서도 이를 위한 데이터 공유가 활발히 이루어져야 하며, 이를 위하여 연구자들의 인식 제고가 필수적임. 한국생물공학회에서는 과학기술정보통신부 지원을 받아 바이오 데이터 엔지니어 인력양성사업을 수행하고 있음. 사업을 통하여 (1) 청년 예비 바이오 데이터 엔지니어 300명 선발 및 채용, (2) 데이터 수집 및 공유에 대한 인식 제고 활동, (3) 연구 데이터 등록을 추진하고 있으며, 사업 관련 성과발표회를 통하여 지도교수 및 엔지니어들의 사업 활동 내용을 공유하고자 함.
Speaker	Affiliation	Title
	교수 하석진 강원대학교	바이오 데이터 엔지니어 인력양성 사업 추진경과 보고
	엔지니어 주은경 한국생물공학회 (파견근무기관 : 이화여자대학교)	엔지니어 우수사례 Ⅰ
	엔지니어임재은 한국생물공학회 (파견근무기관 : 상명대학교)	엔지니어 우수사례 Ⅱ
	교수 김상오 상명대학교	참여기관 우수사례

Co-organized by

학술연구교류회 성과발표회		기획사업위원회
Instruction	학회에서는 회원들의 학술정보교류 및 연구회 활동 지원을 위하여 학술연구교류회 지원사업을 추진하고 있음. 본 사업은 학회 내부에서 운영하는 사업으로 지원받는 교류회 참여자들은 학회에서 수행하는 기획사업, 용역사업 자문 활동, 신규기획연구과제 도출에 참여하며 활동하게 됨. 이번 행사를 통하여 2021년도 지원사업들의 발표를 통하여 성과를 공유하고자 함.
Speaker	Affiliation	Title
	교수 김교범 동국대학교	Ex vivo cell surface engineering for immuno-cancer therapy
	교수 김문일 가천대학교	감염병 대응 바이오나노-인공지능 융합형 진단기술 연구
	교수김희택 충남대학교	합성생물학 기반 플라스틱 폐기물 활용 미생물 제작 기술
	교수 김현욱 강원대학교	생물공학 기반 스마트 헬스케어 융합기술 개발

과학기술의 효율적인 대중 소통을 위한 협력 패러다임 전환과 도전		president Jeongmo Yi (Gwacheon National Science Museum, Korea)
Instruction	The Korea Foundation for the Advancement of Science and Creativity [KOFAC] is a quasi-government and non-profit organization under the Ministry of Science and ICT. Since its establishment in 1967, KOFAC has continued to prosper and grow as a center for expanding science culture and nurturing creative talents in order to allow anyone and everyone to easily understand and encounter science in their daily lives.
Speaker	Affiliation	Title
	Keynote Speaker president Jeongmo Yi Gwacheon National Science Museum, Korea	Public Responsibilities to Spread Science Culture
	Invited Speaker Professor Eungbin Kim Systems Biology and Research Institute of Liberal Education, Yonsei University, Korea	Science Communication from the Perspective of Biotechnology and Convergence Science
	Invited Speaker DirectorLee Eun Hee Galdar SCC, Korea	Key know-how for writing scientific literature
	Invited Speaker CEO(Science Explorer) Kyungsoo Moon PLAYLABS, Korea	Science and culture activities using entertainment and documentary programs.

Co-organized by

[S7-1] Repligen 런천세미나 I
The current manufacturing processes for viral vectors for gene therapy, which we can define as Gene Therapy Manufacturing 1.0 (e.g., adherent cell culture and transient expression from plasmid transfection), are not productive enough to meet the future demand considering the quickly increasing number of approved gene therapies and clinical trials. A transition is therefore ongoing to implement more productive and scalable processes, leading to Gene Therapy Manufacturing 2.0 using suspension cell culture and developing producer cell lines. Adopting the right technology solutions on this journey is essential.
Speaker	Affiliation	Title
	Rene Gantier, Ph.D. Director of Technology for Gene Therapy at REPLIGEN	In this talk we: Evaluate the near-future needs for gene therapy manufacturing Discuss the major technology challenges posed to quickly develop high-productivity, -safety, and -quality manufacturing processes for viral vectors Propose technology solutions for upstream (perfusion cell culture) and downstream (tangential-flow filtration and chromatography) processing to overcome these challenges.

[S7-2] TWISTBIOSCIENCE 런천세미나 II
Novel strategies towards enhancing enzymatic properties such as catalytic activity, specificity and stability have opened up a plethora of novel applications for industrial production, agriculture and sustainability. Such improved enzymes are typically identified in high throughput functional screening campaigns by either investigating the vast number of naturally occurring microbial homologs or by exploring the synthetic combinatorial space of given amino acid motifs. Both strategies rely on the ability to generate high numbers of DNA templates. At Twist Biosciences we have revolutionized DNA synthesis in terms of scale, uniformity and error rate. The resulting high-quality products such as clonal genes and DNA variant libraries comprise the ideal basis for high throughput functional screenings for enhanced enzyme variants. In this seminar we will give an introduction to Twist Bioscience, our products and show how we change the game of enzyme engineering.
Speaker	Affiliation	Title
	Bernd Willems, Ph.D. Libraries and SynBio Application Specialist Twist Bioscience	Twist Bioscience–Writing the Future of Enzyme Engineering

[S7-3] Molecular Devices 런천세미나 III
For the synthetic biologist, biological building blocks are often generated from bacteria. The design-build-test process is utilized in order to engineer these building blocks. This often requires screening and picking colonies of interest. Traditionally, colony picking is performed manually using sterile pipette tips, toothpicks, or inoculation loops, which is a slow, labor-intensive, and time consuming process. Synthetic biology research can, therefore, benefit greatly from the flexibility and throughput of automated colony pickers. Not only will automated colony pickers make the entire process quicker (picking up to 3,000 clones per hour), but the results are more consistent and reliable, increasing the quality of the data produced
Speaker	Affiliation	Title
	탁민호 Ph.D. JAPAC BioPharma and Drug Discovery Application Scientist Molecular Devices LLC	The versatility of fully automated bacterial colony picker in synthetic biology
기존 이차원 단층세포 배양 기술은, 실험적 편의성과 값싼 비용이라는 장점을 바탕으로 누구나 쉽게 체외에서 특정세포를 배양할 수 있는 연구플랫폼으로 자리잡았으며, 이렇게 배양된 단층배양세포는 개발중인 신약의 성능과 독성을 평가하기위한 보편적인 in vitro 모델로 널리 사용되어 왔습니다. 그러나, 현저하게 낮은 단층배양 세포의 생체 모사성 때문에 이를 기반으로 도출된 연구결과가 실제 임상에서 재현되지 못하는 사례가 빈번하고, 실제로 전임상 및 임상연구의 높은 실패율을 야기하는 치명적인 한계를 보여주고 있습니다. '미니장기' 라고도 불리는 오가노이드 (organoid)는, 줄기세포로부터 형성된 3차원 세포집합체로, 조직을 구성하는 다양한 세포가 실제 조직의 구조적 특성을 재현하고 있기 때문에 기존 단층배양세포의 한계점을 보완하고 조직내의 생리학적 현상을 모사할 수 있는 새로운 형태의 체외배양 모델입니다. 오가노이드는 이러한 우수한 생체모사성으로 인해 환자 맞춤형 치료제와 재생 치료제 개발과 같은 혁신 바이오 기술의 근간이 될 혁신적인 기술로 평가받고 있습니다. ㈜넥스트앤바이오는 오가노이드 배양기술, High Contents Imaging 등 다양한 첨단 융합기술을 바탕으로 환자맞춤형 정밀의약, 정밀진단키트 개발, 오가노이드기반 당뇨치료제 개발 등 미래지향적 의약학 기술개발을 선도하는 것을 목표로 설립된 회사입니다. 본 발표에서는 ㈜넥스트앤바이오가 연구자들께 제공해 드리고 있는 오가노이드 기반 비임상 연구플랫폼과 그로부터 도출된 연구결과를 소개합니다.
Speaker	Affiliation	Title
	오상택 Ph.D. 수석연구원 Next&Bio	장기 특이적 오가노이드 기반 비임상 연구플랫폼의 활용

PSP01	PCR Chip-adopted Electrochemical Biosensor Module for Diagnosis of Infectious Diseases Won Jae KIM, Jun Yeong JANG, Min Kyung KIM, Jae Hee WON, Chae Min KIM, Minsub CHUNG Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP02	Activated Cell Proliferation by Reactive Oxygen Species Generated from Thimbleful Gold Nanorods Jae Wook LEE¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP03	Biotransformation of Phloretin Using Bacillus subtilis Spore Displayed Tyrosinase Yura JEONG^1,2, Chanjin PARK^1,2, Junehyung KIM^1,2 ¹Department of Chemical Engineering, College of Engineering, Dong-A University, Busan, Korea, ²Center for Sliver-Targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan, Korea
PSP04	Comparison of the Efficiency of Heavy Metal Adsorption on the Cell Surfacedisplayed ECs Ho-Geun JEE, Haewon KIM, Seolhwa LEE, Jong-In WON Department of Chemical Engineering, Hongik University, Seoul, Korea
PSP05	Application of the Porous Ootheca Recombinant Protein by Biomaterials Hye Jin HWANG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Yoo-Jin LEE⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon, Korea, ⁴Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP06	Characterization of Lactobacillus plantarum GNS300 for Various Commercial Applications Jae-Youn JUNG^1,2, Deok-Ho KWON^1,2,3, Yoo-Jin LEE⁴, Young-Keun SONG⁴, Suk-Jin HA^1,2,3 ¹Department of Biohealth-machinery convergence engineering, Kangwon National University, Chuncheon, Korea, ²2Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Korea, ³Institute of Fermentation and Brewing, Kangwon National University, Chuncheon,Korea, ⁴4Prod.Dev.& Marketing Team, The Garden of Naturalsolution Co., Ltd, Osan, Korea
PSP07	Construction of Bi-functional Enzyme of Formate Dehydrogenase and Glycerol Dehydrogenase by Peptide Linker in Methylorubrum extorquens AM1 Seo-young CHOI¹, Hyeonsoo KIM¹, Sukhyeong CHO², Jinwon LEE^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ² Gas Refinery R&D Center, Sogang University, Seoul, Korea
PSP08	Melanin Decolorizing Peroxidase Derived from Bjerkandera adusta Jina BAIK, Taek Jin KANG Department of Chemical Engineering, Dongguk University, Seoul, Korea
PSP09	Cosmetic Effects of Giant Mushroom, Pleurotus nebrodensis Hyo Jung JUNG, Seul Gi KWON, In Hae KIM, Jae hwa LEE Department of Pharmaceutical Engineering, College of Medical & Life Science, Silla University, Busan, Korea
PSP10	Metatranscriptome Analysis of Margalefidinium polykrikoides Harmful Algal Bloom Sang-Hyeok CHO^1,2, Yujin JEONG^1,2, Eunju LEE^1,2,Sangrak JIN^1,2, So-Ra KO³,Seung Ho BAEK⁴, Chi-Yong AHN³, Hee-Mock OH³, Byung-Kwan CHO^1,2, Suhyung CHO^1,2 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KI for BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Biological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, ⁴Risk Assessment Research Center, Korea Institute of Ocean Science and Technology, Geoje, Korea
PSP11	Assessment of Antibiofilm Potencies of Nervonic and Oleic Acid against Acinetobacter baumannii Using in vitro and Computational Approaches Sagar Kiran KHADKE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP12	Surface Modified PLGA Nanoparticles by Phospholipid for Enhanced Stability and Tissue Penetration Efficiency Doyeon KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, 2Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP13	Improved High-temperature Stability to Solve Cryogenic Transportation and Storage Problems of mRNA Vaccines Minjeong KIM, Taekyoung LEE, Hyunjin KIM, Heejae BANG, Minji KIM, Minsub CHUNG Chemical Engineering, Hongik University, Seoul, Korea
PSP14	Antibiofilm Activity of Saw Palmetto Oil, Lauric Acid, and Myristic Acid on Polymicrobial Biofilms Sang hun KIM, Sun young PARK, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP15	Inhibition of Biofilm Formation and Hyphal Growth of Candida albicans by Mediumchain Fatty Acids Ye Seul KIM, Afreen JAILANI, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP16	Self-assembled Nanocomplex-mediated siRNA Delivery Using Novel Fusion Peptide Yeong Chae RYU¹, Kyung Ah KIM¹, Byoung Choul KIM^1,2, Hui-Min David WANG³, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea, 3Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan
PSP17	Inhibition of Cutibacterium acnes Biofilm Formation by Fatty Acids Including Myristoleic Acid Sun young PARK, Sang hun KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea

PSP18	Diverse Roles of Microbial Indole Derivatives in Eukaryotic Systems Bharath Reddy BOYA, Prasun KUMAR, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP19	Review of pDNA Gene Delivery System Kyoungyeon OH¹, Eunbi LEE¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP20	Inhibition of Biofilm Formation and Virulence of Vibrio parahaemolyticus by Chloroindoles Olajide Sunday FALEYE, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP21	shRNA-based Gene Therapy System Using Functional Peptides for the Treatment of Psoriasis Yoo Eun LEE¹, Yeong Chae RYU¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Devision of Bioengineering, Incheon National University, Incheon, Korea
PSP22	Non-invasive Cancer Diagnosis System Using C. elegans-on-a-chip and Odorant Markers Nari JANG¹, Arvie Camille V. DE GUZMAN², Shin sik CHOI^1,2 ¹Department of Food and Nutrition, Myongji University, Yongin, Korea, ²Department of Energy Science and Technology, Myongji University, Yongin, Korea
PSP23	Combination of Chemotherapy and Sonodynamic Therapy with Polylactide-poly (ethylene glycol) Polymersomes for Effective Cancer Treatments Youngheun CHO¹, Taeho KIM¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP24	Antibiofilm and Antivirulence Activities of Fatty Acids Afreen JAILANI, Ye Seul KIM, Jintae LEE Department of Chemical Engineering, Yeungnam University, Gyeongsan, Korea
PSP25	Development of Polymersomes Co-deliverying Dual-drug for Overcoming Multidrug Resistance EunKyung HAN¹, Hyuncheol KIM^1,2 ¹Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Korea, ²Department of Biomedical Engineering, Sogang University, Seoul, Korea
PSP26	Designer Lipid Droplet Promotes Production of Value Added Biochemicals by Increasing the Storage Capacity So-Hee SON^1,2, Soo Young MOON³, Yeong-seon JANG¹, Seung Soo OH^2,3, Ju Young LEE¹ ¹Research Center for Bio-based Chemistry, Korea Research Institute of Chemical Technology (KRICT), Ulsan, Korea, ²School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea, ³Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
PSP27	The Enhanced Production of Succinic Acid Using Engineered Type I Methanotroph Methylomonas sp. DH-1 Jeong-Ho PARK¹, Jae-Hwan JO¹, Min-sik KIM² ¹Gwangju Bio/Energy R&D center, Korea Institute of Energy Research, Gwangju, Korea, ²Energy Resources Upcycling Research Laboratory, Korea Institute of Energy Research, Daejeon, Korea
PSP28	Reconstruction of a Genome-scale Model of Eubacterium limosum Converting C1 Feedstocks to Multi-carbon Products Jiyun BAE, Yoseb SONG, Byung-Kwan CHO Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP29	Effect of Various Structured DNA on the Activity of Terminal Deoxynucleotidyl Transferase Myong Jin LEE, Eui Kyong JANG, Ki Sung PARK, Ki Ha MIN, Sung Ho KIM, Seung Pil PACK Department of Biotechnology and Bioinformatics, Korea University, Sejong, Korea
PSP30	Systematic Analysis on Transcription Unit Architecture of Streptomyces avermitilis Yongjae LEE¹, Namil LEE¹, Soonkyu HWANG¹, Woori KIM¹, Suhyung CHO¹, Bernhard O. PALSSON^2,3,4, Byung-Kwan CHO¹ ¹Department of Biological Sciences and KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ³Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁴Novo Nordisk Foundation Center for Biosustainability, Lyngby, Denmark
PSP31	Construction of the Knock-out Mutant Using a Purified Cas9 Protein in Chlamydomonas reinhardtii Junhwan JANG, Yoongil LEE, EonSeon JIN Department of Life Science, Hanyang University, Seoul, Korea
PSP32	Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome Soonkyu HWANG^1,2, Namil LEE^1,2, Donghui CHOE^1,2, Yongjae LEE^1,2, Woori KIM^1,2, Yujin JEONG^1,2, Suhyung CHO^1,2, Bernhard PALSSON^3,4,5, Byung-Kwan CHO^1,2,6,7 ¹Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ²KAIST Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea, ³Department of Bioengineering, University of California San Diego, La Jolla, CA, USA, ⁴Department of Pediatrics, University of California San Diego, La Jolla, CA, USA, ⁵Novo Nordisk Foundation Center for Biosustainability, Kongens Lyngby, Denmark, ⁶Intelligent Synthetic Biology Center, Daejeon, Korea, ⁷Innovative Biomaterials Research Center, KAIST Institutes, Korea Advanced Institute of Science and Technology, Daejeon, Korea
PSP33	Cloning and Expression of Single-chain Variable Fragment Targeting Epidermal Growth Factor Receptor Seong Yong YOON¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP34	Gene Cloning, Expression, and Characterization of Anti-human Estrogen Receptor Alpha 36 Single Chain Fragment Variable Doo Young LIM¹, Byeong Hee HWANG^1,2 ¹Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea, ²Division of Bioengineering, Incheon National University, Incheon, Korea
PSP35	Cloning and Expression of C6.5 Single-chain Variable Fragment Targeting Human Epidermal Growth Factor Receptor Type2 Hye Min JO, Byeong Hee HWANG Department of Bioengineering and Nano-bioengineering, Incheon National University, Incheon, Korea

P0001	Magnetic Particle-based Aptamer Selection for the Detection of Various Analytes Myeongjune GO, Seung-Woon JUNG, Seung Min YOO School of Integrative Engineering, Chung-Ang University, Seoul, Korea
P0002	Highly Sensitive Gold Nanourchin for Rapid Bovine Coronavirus Detection Ruth STEPHANIE, Sung Hyun KIM, Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0003	Rosette-shaped Graphitic Carbon Nitride as a Highly Efficient Peroxidase Mimic for Glucose Biosensing Thinh Viet DANG¹, Yun Suk HUH², Moon Il KIM¹ ¹Department of BioNano Technology, Gachon University, Seongnam, Korea, ²Department of Biological Engineering, Inha University, Incheon, Korea
P0004	Continuous Synthesis of DMPC/DHPC Bicelle Using Hydrodynamic Focusing Micro-mixer and Analysis of Its Physicochemical Properties Bong Su KANG¹, Sung Hak CHOI², Kee Sung KIN³, Ho Sup JUNG², Moon Kyu KAWK¹ ¹School of Mechanical Engineering, Kyungpook National University, Daegu, Korea, ²Center for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University, Seoul, Korea, ³Research Inst. of Advanced. Materials, Collage of Engineering, Seoul National University, Seoul, Korea
P0005	Towards Reliable Marine Toxin Detection: Discovering Saxitoxin-specific Bioreceptor via Phage-display Technique So Yeon KWEON, Chan Yeong PARK, Ruth STEPHANIE, Sung Hyun KIM, Yeong Hyeock KIM, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0006	Screening of Aptamers Against Bst Polymerase for Increasing Reverse Transcriptase Activity Do-Young KIM¹, Woo-Ri SHIN¹, Simranjeet Singh SEKHON¹, Sang Yong KIM², Ji-Hyang WEE², Ji-Young AHN¹, Yang-Hoon KIM¹ ¹Major in Microbiology School of Biological Sciences College of Natural Sciences, Chungbuk National University, Cheongju, Korea, ²Department of Food Science and Biotechnology, Shin Ansan University, Ansan, Korea
P0007	Development of Cholesterol Detection Based on the Bienzyme Nanoparticle by Electrochemical Measurement Min Woo KIM, Chan Yeong PARK, Tae Jung PARK Department of Chemistry, Chung-Ang University, Seoul, Korea
P0008	Effective Treatment for Cervical Cancer Through Folic Acid Modified Bovine Serum Albumin Nanoparticles Combining Chemo-photodynamic Therapy Suheon KIM¹, Hoomin LEE¹, Shruti SHUKLA², Vivek K. BAJPAI³, Young-Kyu HANC³, Yun Suk HUH¹ ¹Department of Biological Engineering, NanoBio High-Tech Materials Research Center, Inha University, Incheon, Korea, ²Department of Food Science and Technology, National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonipat, Haryana, India, ³Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, Korea
P0009	Co-encapsulation of Multiple Enzymes and Cofactors into Nanoparticles Seoungkyun KIM, Kiyoon KWON, Giyoong TAE, Inchan KWON School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea
P0010	Fabrication of Electrochemical Aptasensor that Ag⁺ Ion Intercalated-DNA 3Way Junction on Micro-gap for Interferon Gamma Detection in Human Serum Seungwoo NOH, Taek LEE Department of Chemical Engineering, Kwangwoon University, Seoul, Korea
P0011	Development of Bioelectronic Nose Using Human Olfactory Receptor-embedded Nanodiscs for Diagnosing Gastric Cancer Dongseok MOON, Tai Hyun PARK School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, Korea
P0012	Intein Spliced Di-nanoperforator with Higher and Broad-spectrum Anti-influenza Activity Seokoh MOON, Mi Soo KIM, Dae-Hyuk KWEON Department of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, Korea
P0013	Fabrication of Electrochemical Biosensor for H1N1 Detection Jeongah PARK Kwangwoon University, Seoul, Korea

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로그인 주의사항
로그인 주의사항 1) 강연물에 대한 온라인 접속 권한은 2021년 10월 6~9일 동안 가능합니다. 2) 등록자에 한해서만 접속이 가능하고 아이디와 비밀번호를 타인과 공유하거나 알려주는 행위 등은 전면 금지됩니다. Q&A 주의 사항 3) 강연에 대한 질문은 ZOOM 채팅창에 이름/소속을 입력 후 작성해주시기 바랍니다. 강연물 저작 재산권법 4) 2021 한국생물공학회 추계학술발표대회 및 국제심포지엄에 등록된 각종 자료는 저작권법으로 보호됩니다. 따라서 저작권법에 위반하여 각종 자료를 등록자 본인 외 제 3자에게 배포 및 전송, 복사하는 행위는 민·형사상 책임을 질 수 있으니 유의하시기 바랍니다. 위 사항을 모두 확인하셨으면 확인란에 체크해주시기 바랍니다.	확인
개인정보 활용 동의 (필수) 본 홈페이지는 등록자의 개인정보를 아래와 같이 처리함을 알려드립니다. 1. 개인정보의 수집·이용 목적 한국생물공학회에서 수집한 등록자 개인정보는 향후 학회 소식 및 홈페이지 이용권한을 위한 용도로만 활용되고 학회 참가기업의 등록자 정보 데이터를 확인하기 위하여 제공될 수 있습니다. 2. 수집하려는 개인정보의 항목 성명, 이메일, 휴대전화, 직책, 소속기관, 소속명 3. 개인정보의 보유 및 이용 기간 등록된 정보는 본 학회 종료일 이후 1년간 보유하며, 삭제 요청 시 요청자의 개인정보를 재생이 불가능한 방법으로 즉시 파기 합니다. 4. 개인정보의 제3자 제공 수집하는 개인정보를 목적 외의 용도로 이용하거나 제3자에게 제공하지 않습니다. 5. 권리 원칙적으로 개인정보 보호법에 의해 개인정보 수집 동의를 거부할 권리가 있습니다. 다만, 동의가 없을 경우 저작물 접근이 원활하게 진행되지 않을 수 있습니다. 본인은 개인정보보호법에 따라 위 각호 사항을 고지받고 개인정보 활용에 동의합니다.	동의